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Can Metoprolol become less effective at reducing heart rate over time? I've been taking it for about 2 years now. About 6 months ago my heart rate returned to its prior levels (high 50s for resting and low 60's for walking, etc). Nothing bad, but it was a curious step function in the charts. When the drug was working, it had reduced those levels by about 10 beats/minute. My cardiologist doesn't know of any reason why this should happen, so I'm checking to see if others have seen this.. I started to take a GLP-1 (ZEPBOUND) around the same time and wonder if that could be related. ## Metoprolol doesn't usually "wear off" the way some medicines do, but people can see changes in how it affects their heart rate over time. Sometimes your body just adapts a bit, or ...

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I have been getting the generic Subutex Roxane brand 54 411 Buprenorphine tablets for months now from Walmart pharmacy and the past two times I've gotten my prescription filled there, I was given a different generic made by Hi Tech with an 8 and an arrow. I asked them why the change because those little tablets just are not the same and they said the Roxane ones could not be ordered. I called around to other pharmacies I have gotten my prescription filled at before also and was also told that the Mylan M 924s can no longer be ordered either. What's going on with the Roxane and Mylan Buprenorphine tablets? Did they stop making them or is there some kind of shortage? I had the choice of getting the small Hi Tech tablets which seem alot less potent than the Roxane or the Actavis 15...

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Does anyone use the generic by lupin pharma? I used mylan 100 mag for 20 years and they claim on back order. I asked for 88 because another generic gave me anxiety and rapid heart beat. Since I been on lupin have had chronic headache lower leg cramps nausea and sleepiness. Going back up to 100. I hate being a guinea pig. I also have M.S. and spine problems

I have been taking Sotalol Teva for over 15 years and picked up a new prescription at Wal-Mart and received a different brand (Apotex). I called and the pharmacist said they were the same. My heart seems to disagree and is hopping around. Maybe like drinking coke for 15 yrs and then them throwing in a Pepsi. LOL. Is it my mind or what? My heart is giving me a "not in my head" reaction. ## Hello Jack, I hope that you are doing well. After doing some research I found that both Sotalol pills have the same active Ingredient SOTALOL HYDROCHLORIDE 120mg but where the two pills differ is the listed inactive ingredients. Teva reportedly contains these inactive ingredients: - Starch, Corn - Lactose Monohydrate - Magnesium Stearate - Povidone K30 - Fd&c Blue No. 2 - Indigotindisulfona...

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White round pill with T, score line and N on one side, and a correction tick type of symbol on the other side. ## I don't know if this is the exact pill you're describing, but I was able to locate a round white pill with T N over a score line and 1 underneath it on one side and on the back is some sort of greater than symbol ">". This particular pill turned out to be a 1mg Trandolapril tablet, used for high blood pressure. For verification, the manufacturer is reportedly Cobalt Laboratories and the pill itself carries a National Drug Code of 16252-0541. If anything, I hope this at least helps narrow down prospective pill ID's. Please post back if you find out more information. ## I'm looking for information on Alko-1. It's a round, white, scored tablet. N...

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Would like to know where to get a prescription filled for 100 Oxycodone 30ml ## Why go to Mexico to get them or ordering them from there? I get 150 of them each month from my pain management DR.. If you suffer from severe pain you may be started on the 15MG Oxy's for a few months then raised to the 30MG tablets. If you aren't needing them for pain but just want them for recreational use then you may have a hard time getting them since the DEA had nothing better to do in 2012 than hassle DR.'s and restrict their schedule 2 prescribing ability for those type of drugs. However, if you have real pain issues and have your past records to give to the doc, that helps save the docs rear end cause he can show proof the patient has severe pain issues. NO MATTER what, don't even me...

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Told to take Apixaban after "supposed" pulmonary embolism...but NO proof! They then discovered I had a lung infection on XRay ....s or you will get a heart attack or stroke... (massive scaremongering by Dr.) so ..you MUST take it! Stuck it for 3 months, bloating, massive weight gain, terrible fatigue, brain fog, depression, joint pain, etc. Even tried half the 5mg.... no improvement, now looking at Nattokinase... seems well researched...anyone tried it? I am sick and tired of Big Pharma's denial that these side effects exist and Drs that don't believe it either because they are "not listed"!

Does the Buprenorphine 8mg 460 work as well as 54 411's? I'm curious as I've seen other imprints, just not 460. Please let me know if they are better or worse. ## BETTER. The only thing is they taste a tad worse. I use 1mg a day and these are slightly smaller and worker slightly better in my opinion. ## Among other influential factors, some people may respond better or worse to the different binders/fillers upon switching from one tablet to the next. That said, the only true way to compare efficacy is to go through trial and error with both versions yourself and not solely based off someone else's feedback. Inactive ingredients in the 460 pill are: Lactose Monohydrate, Mannitol, Povidones, Anhydrous Citric Acid, Sodium Citrate, Butylated Hydroxyanisole, Magnesium Stearat...

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I know the oxycodone HCL has some sort of salt in it and it’s just regular oxycodone. And I understand the IR is immediate release. Then they have extended release. But is the oxycodone HCL an extended or an immediate release?? Thank you! ## Oxycodone HCl just means the basic drug - the HCl is a salt that helps it dissolve. It does not tell you if it’s fast-acting or long-acting. - IR means immediate release (works quickly). - ER/XR means extended release (released slowly over hours). So, Oxycodone HCl can be either IR or ER. If your bottle doesn’t say ER/XR, it’s almost always the immediate-release kind. If you'd like, share the NDC code that's on your prescription, and I can look up the leaflet from the manufacturer just to make sure. ## Thank you! Very...

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I keep searching and STILL don¨t have a straight answer. I am currently on 30mg, 3 times a day of OXYCODONE (legally prescribed) for horrific back pain..... ¿WHAT is the difference between the 2, if any, besides the NAME? oxycodone AND oxycontin........ PLEASE help me out! thanks! thanks!! ## Its the same drug - Oxycodone. One is time released (Oxycontin) and one is immediate release (oxycodone). If they changed your meds from Oxycodone 30mg 3xper day (total of 90mg a day) to Ocycontin it would be probably be 40mg 2x a day with breakthrough meds. ## Pita's comment is basically true. Though OxyContin is technically oxycodone hydrochloride - a slightly different formula, but yes -- essentially the same drug. The major difference is the time-released delivery of OxyContin as ...

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My Hydrocodone got wet. Is it still effective? ## How wet did it get? I mean where they soaked in water for a few minutes, or did some just splash on it? Either way, if it was just water, the effectiveness is going to depend on whether or not any of the pill started to dissolve. If it did, then you may not receive all of the dosage and may notice diminished effectiveness. Is there anything else I can help with? ## No they did get wet and some started to disfigure and some did semi dissolve ## A little water got in the pill container some disolved , some disfigured

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I wanted to talk to someone about getting help with cheaper access to this medication. I was given a trial prescription to it and it works great for me but the price for 30 pills is 460 dollars and I can't afford it so I'm unable to purchase my medication and want to know if there are any programs that help people attain their meds. ## As of writing this, the company that makes Avanafil doesn’t have a patient assistance program, but you can use a free discount card to lower the cost. Here is an option you can check: Many pharmacies accept discounts, and this could help to lower the price. Hope this helps!

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I have Diclofenac that was prescribed in late 2006 but has no expiry date. Is it still safe to use? ## Hello, Bob! How are you? I'm not sure how your country handles drug laws and expiration dates, so I can only provide you with information that I am familiar with from the U.S. FDA. From their efficacy studies, when left in the original factory sealed containers, it was found to retain full efficacy for 3 years, but once that container was opened and it was dispensed in a pharmacy/chemist's container that exposes it to the elements that cause degradation, that efficacy could only be guaranteed for one year. It was not, however, found to become dangerous after the expiration date, but after so many years, it is most likely worthless and you should just dispose of it. ## I have Di...

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Has anyone else been prescribed Belbuca? I'm unable to have any other opiates prescribed to me and now I'm on this med. I'm surprised how well it works after a few adjustments to get the dosage right. I'm currently on 600 mcg 2x day. I have lots of back issues and I used to take Hyslinga 30 mg x 2 day and oxycodone 10 mg 5x day. This stuff is much easier to manage then the pills, and the pain relief is great.. ## That's awesome, so very glad that it is working so well for you, since it tends to be hit or miss for some people. The FDA warns that Belbuca does carry the risk of being habit forming, and may cause side effects, such as nausea, dizziness, dry mouth, constipation, and headache. Is anyone else also experiencing good results on this medication? ## The dosage ...

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When I should use pot cl and what are the benefits? ## Hi, Abdo! This is just a potassium supplement, it is vital to our overall health and a deficiency in it can cause quite a few health issues, such as high blood pressure, elevated heart rate and irregular heart rhythm. However, you shouldn't take it, unless your doctor has actually done a blood test and told you that you need to take it, because too much of it can also be very dangerous. Did your doctor prescribe this for you? ## I was prescribed pot cl micro 10 meg along with water pill. Now that I'm not taking the water pill I've been still taking the potassium since August. What danger am in. I feel something going on ## Can I crush these very large tablets? ## What happens if I don’t get enough potassium?

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I have both shoulders with rotator cuff issues. I take a single 5/325 several times a week at night to sleep. Is there any danger of dependency or addiction?

I was using heroin 2-3 times a day for a year. I quit heroin but continued to use pills. I recently could not get pills for about a week. I was extremely ill. So I said enough and went to a methadone clinic to quit everything. They said they would not treat me cause there was nothing in my blood or urine. I got some pills today and am going to clinic tomorrow. My question is how soon will they show up, and will 50 mg of hydrocodone and 20 mg of oxycodone be enough to "fail" the blood and urine tests to get in the program. ## The amount you're taking is more than enough if you have a urine test the following day. Hydrocodone alone can remain in your system for 1-6 days for a urine test; while Oxycodone can be present in urine for 2-4 days. A blood test however may only show O...

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Reading the forum I see that several people have gotten to very high doses very quickly. I just started a week ago at 2.5 and see the doc for bloodwork at 4 weeks. If she sees I'm doing well with all numbers including weight loss, the plan is to continue on that dose another month or longer as long as results are positive. Since I did have nausea and sulfur burps first few days, I'm fine with that. I just don't understand getting to 10 in 4 months. Can someone explain that?

Where can I buy it ## Hi Michelle, The original Borofax ointment (boric acid 5% + lanolin) was actually discontinued in 1993 due to some toxic effects attributed to boric acid. Apparently though, the manufacturer of Borofax reformulated the product and began selling it again. The active ingredients in the new formulation are Zinc Oxide 15% and white petrolatum 68.6%. The newer product does not contain boric acid. The new formulation of Borofax (with Zinc oxide) is available, but may not be routinely stocked by pharmacies on shelves. So a pharmacist may have to special order it for you. Most popular diaper rash products available today contain the similar ingredients. Common examples include: Desitin cream with 40% Zinc oxide, lanolin, and white petrolatum. Balmex cream and A+D cream als...

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I am taking Clonidine for an off label use to treat Bruxism(teeth clenching at night). Currently 0.2mg just at night ,but considering trying 0.3mg. My questions are 1) I've heard some people develop a tolerance to Clonidine after taking it for a longtime(so it becomes ineffective and the dose must be increased or treatment stopped). How long can I take before I should take a break ,so I don;t develop this tolerance? 2) If I take 0.3mg and then want to stop taking it , if i reduce my dose by 0.05(half a tablet) every 3-4 days should that avoid rebound hypertension ? My doctor said withdrawal and tolerance are not problems at all so i can stop cold when i want, but don;t think it is a drug she has experience prescribing (only prescribed it as I suggested trying it ,from studies I had ...

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