Glyx-13 Discussion (Page 4)
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There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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REPORT

Ketamine is very cheap! I obtained a vial of 100mg/10mg for $60. It's the infusion services where they get you. A lot of room for charlatans to abuse their medical priviliges to enrich themselves from desperate people. I tried IM injections of 50 mg ( the recommended dosage) but did not get the effects that the infusions provided. So I stopped. Now on Geodon + AD's which has helped to stabilize me for now. But don't feel as great as I did while in the Clinical Trials using Ketamine. It was me, but better! Someday...

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gillm,

Given that these drugs are still in phase II clinical trials, it's probably going to be a few years before they receive approval. But there might be a drug trial conducted in your part of Italy at some point. The website clinicaltrials.gov lists trials that are conducted both in the U.S. and other countries.

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I seem to be somewhat drug resistant. I am bipolar 2 and have altogether 18 years of therapy 11 of it full time. And over the last 9 years a range of ssri's. I am currently taking Wellbutrin, gabapentin, lamictol and sometimes amysulpride. This anti d, has had the best results so far ( which isnt saying much) I still plunge into unbearable depressions and feel stranded with nothing I can take to ease it-- so I am keen to know whenGLYX-13, is going to be available through a psychiatrist free ( as most are here in Italy) Does anyone have any idea about this? and how many mg's are to be taken in this 'single dose'?

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Daisy, what where the side effects of the SSRIs that you weren't able to tolerate?
For me it was sexual dysfunction and akathisia (extreme anxiety with annoying sensations in my legs). I tried remeron as well, but it also gave me some akathisia. I have never been on any neuroleptic, but it seems that my body reacts to increased serotonin as some people react to neuroleptics. Did you experience anything of that sort while on SSRIs?

thanks

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Paula,

Thanks for the reply. It's outrageous what some doctors are charging for these infusions. I was under the impression that ketamine is a generic drug, as it's been around for so long.

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Yes, I was in a clinical trial of Ketamine infusions last summer. No Psychomimetic effects whatsoever. Just 'the miracle' after 3 infusions, which was sustainable with one infusion per week @ 50 mg. in 500cc of saline, infused over one hour. Just felt a little tired after. But like a new, greatly improved me! It was wonderful. But then the study was over. I got 2 infusions from a quack that charged 1k per session. First one was 50mg. Felt a little high after, very short lived. The next time he doubled it to 100mg. Talk about a bad trip! I saw my recently dead mother and was crying. I used to love tripping back in the day, but that really sucked! Never went back. I heard Fiefel was doing infusions, won't be covered by insurance as it's considered experimental. Feel free to ask any other questions.

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Paula, you tried ketamine? Did you experience any of the psycho-mimetic side effects that I've heard about? There's supposedly a doctor here in San Diego, a Dr. David Faifel, who administers ketamine infusions to treat depression. Not sure if it's covered by insurance, though...

I'm participating in the clinical trial of AZD6765 in San Diego. It's closed now, but I'm sure that if they begin a new trial, it'll be conducted in cities across the U.S. Best way to find out is to search it on clinicaltrials.gov

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@ Daisy- where are they doing the study for AD???. I would be very interested in trying that. I am pretty well stabilized on my multiple-med regime, but the effects of Ketamine infusions when I was in that study last year were amazing! I felt like a new, improved me. Although did have some fatigue which was minor after the infusions. It was well worth it! Let me know. Thanks! Be well.

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grouper,

There's been a lot of talk about an open-label, extended study of this drug, so if you're thinking about trying it, you may have an opportunity at that point.

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thank you for your reply Daisy.
Sounds like this drug is going to get to phase III after all. I 'd change a day of fatigue for low libido any time.

All my wishes to you too.

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Hi grouper,

What I've noticed is fatigue, especially the day after a treatment (like today), but it feels very different from my normal, depression-induced fatigue. The other big side effect, at least for me, has been increased appetite, which has led to weight gain of about 3 or 4 pounds. That may be because I'm also taking Remeron, which is notorious for increased appetite; I think maybe the two drugs together are having some sort of synergistic effect on my appetite.

A study doc told me yesterday that other study patients are reporting increased energy and decreased appetite, so you know, like any other drug, I think this one's side effects are going to vary from person.

The only other noticeable side effect for me was some flat affect initially, but that seemed to go away fairly quickly. I have noticed some improvement in memory.

I wish the drug were more energizing for me, but that could be dose-related--I still don't know which dose I'm on. Also, it could be that another of these drugs, like GLYX-13, will help with that (at least that's what I'm hoping).

Overall what I noticed, at least initially, was feeling more content, more level, less anxious, and finding it easier to delve into projects. I'm noticing it less now, possibly because I've tapered down from infusions three times a week to once every two weeks currently.

My opinion from having participated in this trial is that they're definitely on to something with this class of drugs, but that they're going to need fine tuning. In terms of side effects, though, I'll take them over the SSRIs any day.

Hope I answered all your questions. Good luck to you.

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Hi Daisy

If it's not too much to ask, could you tell us a bit more about how the treatment works for you in terms of attention, memory, cognition, energy and emotional depth? I too have quit SSRIs because of terrible side effects and I am awaiting this new drug class. SSRIs made me have dampened feelings and killed my libido. Have you noticed anything similar with AZD6765??

I wish you all the best with the trial.
thanks

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Hey Catpower,

I filled the Rx for Namenda but didn't take it. I forget what I read about the side effects that decided me against it. I wouldn't be surprised if that's what's causing your migraines.

I'm still very pleasantly surprised at how few side effects I've experienced from the AZD6765 infusions compared to all the pills I've tried. I'm having my next-to-last infusion on Wednesday.

Sorry about the weather you're experiencing. I'm originally from NYC, so I know from humidity. Live in San Diego now, which is much more bearable...I've met people who do suffer headaches when the barometer moves in one direction or the other.

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Daisy, after only 3 days on Namenda, it appears to be a migraine TRIGGER for me all. Either that or it's the weather. I'm going to stop taking it and maybe give it another try when the weather clears up, if I can stand the thought of it.

I was curious what side effects you had when you tried it? I had 3 days of unrelenting migraines almost from the minute I took the first pill. Very disappointing to say the least, because I was hoping it would help my anxiety. If anyone else has experience with this, I would appreciate hearing (tho maybe I should switch to the Namenda page - if there is one - arrrrggghhhh)

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Yes, I tried remeron. It didn't help the migraines but made it impossible for me to stop eating :) I haven't met a SSRI or SNRI yet that I can tolerate. Thanks for the thought tho!

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Catpower,

A doctor prescribed Namenda for my depression last year for the reasons you stated, but I was afraid to take it for fear of the side effects I'd read about it.

Regarding your migraines, have you tried the SNRI Remeron (mirtazapine)? I used to get migraines too, and they pretty much disappeared after I started taking Remeron. It's the only a/d I can tolerate, and I still take it. I realize that everyone's different, though.

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Dear All - There's been some discussion on this thread about FDA-APPROVED drugs that are NMDA receptor antagonists (i.e. same class as ketamine, and related to experimental drugs like GLYX-13). One of these approved drugs is Namenda, aka memantine, an Alzheimer's drug that is also being studied off-label for use in migraines, depression and anxiety (among other things, but those are the 3 from which I suffer the most). Anyway my neuro gave me a sample pack yesterday!! so I have started down the Namenda path. The pack is a month's worth so I can't say I've noticed anything yet, in fact I've had 2 migraines since starting it yesterday, but that could be the horrible hot and humid weather we're having in the Chicago area right now. At least I'm hoping it's the weather, because I'll be very disappointed if Namenda turns out to be a freaking migraine trigger for me. Anyway I'll keep posting about this drug if folks are interested. It is a legal drug, available by prescription, and as has been mentioned previously I think works on the glutamatergic system, instead of serotonin like most current ADs. All SSRIs and SNRIs are migraine triggers for me, so this new approach could be a breakthrough for some of us, maybe a lot of us. Best wishes to all :)

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Paula,

AZD6765 is being studied only as an adjunct medication, so you actually have to be on an A/D to qualify for a clinical trial.

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I went to the trial place for GLYX-13 and they were about to interview me to be in the trial. But then, the bombshell...2 week washout period for the Wellbutrin, I can't take the chance of becoming so depressed I will need to be hospitalized. So I decided not to participate. ): The woman there said she had seen some incredible results for people, I know this, I have experienced 'the miracle'. I just can't go back to *the hole*, barely hanging on now. But very interested to hear of others experiences. Best of luck to everyone!

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Temp798,

Yes, there is a placebo. I know that I'm not in that group though, because of the way I'm feeling.

I can post which dose I'm on if/when Astra Zeneca unblinds the trial, if anyone wants me to.

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