Glyx-13 Discussion (Page 6)
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There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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WOW, just googling AZD6765, it appears to have a lot of promise!

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@daisy please send more info!

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BlueheelerCD et al, thanks for the new thread on GLYX-13; it's definitely needed. Well, as I posted on the ketamine thread, I was not accepted for the current on-going phase 2 trial of GLYX-13, but am hoping they start another phase 2 (or 3) trial someday soon that I'll be eligible for. SSRIs and SNRIs don't work for me because I have chronic migraines and they are all migraine triggers for me. For some reason Imitrex (very common and old migraine med) was one of the reasons I was excluded from the GLYX-13 trial. I can only assume they are being extremely strict about who gets in and what meds they are on, but I cried the entire morning when I found out I didn't get in. My neurologist suggested lithium for the migraines, and my psych OK'd it because he thought it would help by depression/anxiety, tho I'm not technically "bipolar". It does seem to be helping everything except I'm taking Pepcid every day for stomach pain. We'll see!

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I'm enrolled in a study of AZD6765, another ketamine derivative, and it's working! Best part is that the side effects are better than the SSRIs, which were awful for me.

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@Jenna, excellent synopsis, I have collected a huge file of articles, trials, etc.. All concurs. I wrote an email to Joe Moskal from an article re: Naurex and INOV @ No. Western, asking him for information about similar drugs, like Namenda, in regard to the possibility of getting some relief until it becomes available, which appears to be along way off...also any possible supplements affecting NMDA receptor, the Glutamate system and Glycine. As it appears it affects memory loss and the diseases associated with it. This has been in research 26 years. Ketamine since 1996. It is available, however the doses are minuscule compared to what they are using...

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@ David yes that was the discussion I was referring to, the main focus ended up being mainly about GLYX-13 so we decided to make a separate thread for it and use that one for ketamine related questions

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Hello,

I don't know much about this topic, but I will do my best to provide some helpful and accurate information.

Based on my research, GLYX-13, is a novel and selective NMDAR partial agonist in development as an optional therapy for patients who suffer from depression and do not respond well to current therapy. According to the National Institute of Mental Health, GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the street drug side effects. GLYX-13 and Ketamine have many similarities but many differences as well. From what I can gather, Ketmaine may cause more side effects than GLYX-13 such as: delirium, dizziness, diplopia, blurred vision, and nystagmus. In clinical trials, administration of one single dose of GLYX- 13 gave extensive results in a 24 hour period, and the results lasted nearly a week. Application of GLYX- 13 is well tolerated. One of the great advances in this therapy is lack of schizophrenia- like symptoms, which have the possibility to occur in treatments with conventional NMDA receptor modulating agents.

Does anyone else have more information to provide?

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Yes this is it!

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From what I could gather, GLYX-13 is said to be a molecular cousin to "ketamine", inducing similar antidepressant properties without the common street drug side effects.

This info was reported from a study funded by the National Institute of Mental Health (NIMH) that was published this past April 2013 in Neuropsychopharmacology.

I think other's who may be in the following Ketamine discussion thread might also find this topic interesting as well. Was this the thread you were referring to by chance?: Discuss/Ketamine-for-Depression-231123.htm

I hope this helps!

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Yeah that would be great, the link to here is posted in the other thread but if you have a way to get ahold of them that would be good.

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Great! Do u need me to help notify everyone who has written about it? Especially because two people are currently in studies!

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