Glyx-13 Discussion (Page 5)
(Newest replies first)

There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

REPLY

REPORT

Please add me to the GLYX-13 discussion thread...I am in the ketamine thread.

REPLY

Was this helpful? 0

Daisy- what are the specifics of the AZD6765 trial? You mentioned that there was a high-dose and a low-dose group. Is there a placebo group? Typically these trials will always have a placebo group.

REPLY

Was this helpful? 0

As I stated before, I'm in a trial of AZD6765. I don't live in LA, but you can check to see which trials are being conducted there by going to clinicaltrials.gov

REPLY

Was this helpful? 0

All-sorry I just can just type faster. Time will tell. Ketamine is Not sanctioned by the National Institute of Mental Health. Nor is anyone trying to get approval from the FDA for an Intravenous Anesthetic for Depression. Nor are there anymore trials. Dangerous side effects,
Daisy, are you in LA? me too. Who is your regular Psychiatrist?
Where are you doing the GLYX-13 trial?
I got rejected for Breast Cancer. I cannot get into any trials.....
I called USC way back. They only use it for pain for a specific type of disease for pain treatment. That is what they told me on the phone. The MD that was doing it at UCLA, where I go, stopped.....

REPLY

Was this helpful? 0

Blueheelercd, are the caps on for a reason? Feels like you're shouting...

There is actually a doctor administering ketamine intravenously for depression in my city, I've been told. His name is Dr. David Faifel, and he works at UCSD Medical Center.

REPLY

Was this helpful? 0

ALL - TRD IS TREATMENT RESISTANT DEPRESSION
MDD - IS MAJOR DEPRESSION DISORDER
NASAL SPRAY OF ANYTHING DOES NOT HAVE ENOUGH BIO-AVAILABILITY AND DOES NOT CROSS THE BRAIN BARRIER. THIS HAS ALREADY BEEN PROVEN IN CLINICAL TRIALS AND SCHOLARLY ARTICLES.
YOU ARE JUST GETTING RIPPED OFF.
KETAMINE AND GLYX-13 ARE NMDA RECEPTOR MODULATORS.
THAT IS WHY IT IS EXCITING THAT THERE ARE AT LEAST TWO OTHERS THAT ARE ALREADY IN USE, FDA APPROVED, AVAILABLE NOW. MINIMAL SIDE EFFECTS. PILLS. BIOAVAILABLE! THIS IS WHAT IS SO IMPORTANT.
IT WILL BE AGES BEFORE GLYX-13 IS AVAILABLE.
THAT IS WHY WE HAVE TO ASK OUR DOCTORS FOR WHAT CAN POSSIBLY WORK NOW PLUS AN OLD RELIABLE ANTIDEPRESSANT WITH THE FEWEST SIDE EFFECTS.
DAISY-THAT IS WHAT AN MDNA RECEPTOR MODULATOR DOES, IT WORKS ON ALL COGNITIVE PROCESSES. GLAD TO HEAR IT HELPED!
BEFORE TRIAL WERE YOU BEGINNING TO OR HAD COGNITIVE AND MEMORY PROBLEMS????
NEW INFORMATION HAS COME OUT THAT BECAUSE KETAMINE IS SO DANGEROUS AND CONTROLLED IT WILL NEVER BE AVAILABLE. THE BEAUTY IS THAT IT OPENED UP THIS WHOLE NEW ARE OF BRAIN RESEARCH CALLED THE GLUTAMATE SYSTEM AND ITS DISFUNCTION BEING A MAJOR PLAYER IN DEPRESSION.

REPLY

Was this helpful? 0

BlueheelerCD, can you post the link to the 2012 pubmed article? I don't think MedsChat has a problem with posts tho seems like sometimes they like to review stuff before posting. Thanks and thanks for all the info.

REPLY

Was this helpful? 0

Blueheelercd, yes, I've noticed a slight improvement in memory. What is a TRD, btw?

Had another treatment yesterday. Feeling pretty tired today, but I know it will wear off.

Catpower, I tried the ketamine nasal spray, and it made me feel really strange, so I discontinued. I would sure like to give the esketamine spray a try if/when it's approved, though.

REPLY

Was this helpful? 0

ALL, ACCORDING TO A 2012 SCHOLARLY ARTICLE, IT IS POSSIBLE THAT THERE ARE OTHER NMDA RECEPTOR MODULATORS, IN USE, AND FDA APPROVED, SAFE, BEING USED FOR OTHER HEALTH ISSUES RELATED TO THE SAME AREA OF THE BRAIN AND THE GLUTAMATE SYSTEM.
IT IS POSSIBLE THAT ONE OF THEM COULD ACCELERATE AND OR ENHANCE ANTIDEPRESSANT EFFECTS OF CURRENTLY AVAILABLE TRADITIONAL ANTIDEPRESSANT DRUGS.
THIS IS THE BEST NEWS YET, AS IT IS ALL SAfe and available now!
i.e. MEMANTINE AND AMANTADINE ARE BOTH NMDA RECEPTOR AGONISTS, WITH FLUOXETINE.
APPARENTLY AN NMDAR IS NOT THE WHOLE STORY, AS SHOWN BY THE TEMPORARY IMPROVEMENT WITH ALL OF THESE NOVEL MNDA RECEPTOR AGONISTS. THAT THE NEURO TRANSMITTERS AFFECTED BY ANTIDEPRESSANTS ARE STILL AN IMPORTANT PART OF THE PICTURE. NEITHER ALONE WORKS.
AS OF NOW THERE IS NO RX FOR TRD.
IF ANYONE WANTS TO READ ORIGINAL ARTICLE FROM PUBMED, LET ME KNOW AND I WILL SEND THE LINK. I AM GOING TO START ASKING MY DOCTORS FOR THESE MEDICATIONS, SINCE THEY ARE SAFE AND TRADITIONAL.
****HAVE ANY OF YOU LONG TIMERS NOTICED COGNITIVE IMPAIRMENT?
IT APPEARS THAT UNTREATED TRD CAUSES IT AS WELL AS EARLY DEMENTIA. THIS IS SCARRY, AS I HAVE NOTICED EVER INCREASING.
EARLIER HELP MAY BE COMING!

REPLY

Was this helpful? 0

All - below is hopefully a link to an article about J&J's phase 1 drug, esketamine! There is a (ph 1) trial going on in Belgium right now showing good response. Sounds like the whole NMDA receptor theory in depression/anxiety is Pharma's big new thing. Note, esketamine is an intranasal spray, not an IV drug. ****YAY****

seekingalpha.com/article/1542392-from-party-drug-to-antidepressant-johnson-johnson-vs-rivals?source=email_rt_article_readmore

REPLY

Was this helpful? 0

@Catpower- I will look for the DBT, I never heard of it either.
AZD6765 - I did a lot od research, especially in other countries. It is almost the same as Ketamine, and lasts a vert short time. Shorter than Ketamine.
@Daisy too, what will happen when the studies are over? Will you still be able to get the medication? Or when it's over, it is over?

REPLY

Was this helpful? 0

Blueheelercd,

Btw, infusion because sponsor supposedly tried pill form, and it wasn't as effective.

REPLY

Was this helpful? 1

Catpower,

Interesting! I'd never heard of DBT therapy before. I'm going to ask my doctor about it the next time I see her.

If anxiety is a problem, I should tell you that the most noticeable difference for me has been in my level of anxiety, which has gone way down since I started the infusions.

REPLY

Was this helpful? 0

Blueheelercd,

It's not a panacea, but I've definitely noticed an improvement in my symptoms, both in mood and functioning. The only real side effects for me seem to be sleepiness and an increase in appetite (I've heard that other patients have experienced a decrease in appetite).

I'm hoping that the sponsor unblinds the study once they've gathered all the data so I can find out what dose I'm on. It could be that I'm on the lower dose, and that the higher dose will prove to be more effective.

In any case, my depression has lifted enough that If there is an open label extended study, I definitely plan to enroll in that.

REPLY

Was this helpful? 0

@blueheelercd - My heart is with you. OK, something I have found very helpful recently is my therapist recommended I join a DBT group (dialectical behavioral therapy). It is a skills-based group where you learn how to handle difficult emotions, how to relax (through mindfulness meditation) and a number of other things - it is VERY powerful. It was originally developed for people with borderline-personality disorder in the 90's but is now being used for all kinds of problems - bipolar, severe depression, anxiety, you name it. There are groups all over the country now. Typically they are run (and should be) by a trained clinician. I never thought it would help me and when my therapist suggested it I was furious! Having tried other "process" groups like AA and NA, I wasn't sure how yet another group would help me - I didn't understand that DBT is skills based, so you are not just crying about your problems with no end in site. I hope I'm not overstepping in suggesting this, but maybe other people will find it helpful. I was so anxious when I started the group I didn't think I could drive the 10 miles to get there - or even get into my car! I share your frustration with the lack of good medications and the difficulty in getting into clinical trials. I have hope that maybe I'll be able to get into a AZD6765 trial and meanwhile I rely on my psychiatrist to help me find approved drugs that will help. I hope you have a psych. that you trust - that and a good therapist are what keep me going. If it weren't for them I probably wouldn't be here writing this. Hang in there and keep posting! We need each other; hope that isn't too corny but I believe it.

REPLY

Was this helpful? 0

@Daisy - how do you feel? has your depression lifted? if so, for how long? side effects?
why iv infusion? thanks

REPLY

Was this helpful? 0

@catpower, but how long realistically until doctors can treat us and help us? ??? i really do not know how much more i can suffer...my quality of life is unsustainable...

REPLY

Was this helpful? 0

Catpower, I couldn't get into the GLYX-13 study either, which was why I looked into the AZD6765 study. I take Imitrex, too, and it was allowed, along with everything else I take except for Dexedrine, and I was allowed to wash out of that.

Hang in there. I think these drugs are showing so much promise that new trials will be starting soon.

REPLY

Was this helpful? 0

Based on personal experience, I think so too. :-)

REPLY

Was this helpful? 0

Sure, what would you like to know? The clinical trial consists of 15 intravenous infusions; I've had 11 so far. There are three arms: placebo, 50 mgs of the drug, and 100 mgs of the drug. (The study is double blind, but I'm sure I'm receiving the study drug, I just don't know which dose.) The infusions last an hour, and once they get the IV in, it's actually very pleasant.

Astra Zeneca supposedly has plans to start an open label extended study once this one is completed.

REPLY

Was this helpful? 0

high pertensition drug ## I have been taking this medication for years, but in Canada, the drug store, does not know wha...

8 REPLIES

I am having hereditary chronic asthma. I am 40 and otherwise physically very fit. I attend gym and go on walks, keeping ...

3 REPLIES

I'm 69 years old and have been on 50 Fentanyl patch for about a year. I've gone down to 37 and having stomach cr...

1 REPLY

MOA OF ZIPSOR ## Zipsor contains the active ingredient Diclofenac, this is a nonsteroidal anti-inflammatory, used to tre...

2 REPLIES

I'm on suboxone and would like 2 chat with others. Is that possible? ## I'm on suboxone 2 and mould like 2 chat ...

13 REPLIES

Find a doctor who will write me prescription for my lower back pain was taking 15 mg of oxycodone. Live in Baltimore cit...

2 REPLIES

I need to know what this drug is used for? ## sinus infections ## My infant son was perscribed this medicine to help wit...

9 REPLIES

About to start Zepatier and would like to hear from others who are taking it or have taken it. -How's it going? -Did...

24 REPLIES

I have to start taking Sintrom today. Do l have to take it at the same time every day, and if so, when is the best time ...

3 REPLIES

cathil Says: Tuesday, 9/19/2006 5:45:47 PM oops forgot the rest! as I said I have been on methadone for several years no...