Glyx-13 Discussion (Page 3)
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There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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The first dose is either a low dose or therapeutic, as I understand it. I felt nothing. After the first dose, it is double blind. I concluded that I was either on placebo or that it does nothing for me some time ago. The lack of hope along with the winter months made the depression worse. I have little to lose by starting the open label study just in case I never had A therapeutic dose. Also, when I finish the study, the open label should just about start. I will post any info I get.

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citygirl,

Do you think you're on placebo?

Thanks for posting about the glyx-13 trial delay. I've been checking clinicaltrials.gov periodically because I'd like to try to get into the new trial when it begins.

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citygirl,

I had no idea that it had been discontinued. Thanks for posting. I guess glyx-13 will be the one to watch from now on.

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I just read (on Wikipideia) that Astra Zeneca has stoped development of AZD6567.

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Tomorrow will be my 10th "treatment" in the glyx-13 study in Chicago. I have not experienced improvement. I am told the open label study is a bit behind the original schedule but on track for an April start. I wonder why Astra Zeneca is not going forward with an open label study at this time?

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My problem has always been severe hypersensitivity to the side effects of the antidepressants. I tried Fetzima a couple of weeks ago, and it hit me like a ton of bricks.

I'm about to try Brintellix, another new a/d, but I'm hesitant because I don't want to be disappointed again. Has anyone here tried it?

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Good question, lol :-)

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Hi JohnL

It's good news to hear that you had a complete remission during glyx-13 infusions. I would like to ask if you experienced any side effects during the period you were on it, and if there were any withdrawal symptoms besides headache. Also, are you sure you were on the drug and not on placebo?

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Hi Everyone,

I was in the double blind AZD6765 study last spring and summer. I reported here that I noticed a big improvement in my depression. On December 31, I was notified that I had received PLACEBO.

I was totally stunned by the news, as I not only felt better during the study, but different than I ever had before. Has anyone else here had the same experience?

I was also told that the study sponsor, Astra Zeneca, has no plans to start an open label study at this time, no explanation as to why (I was previously told that they might conduct an open label study after the phase II trial ended). So that was disappointing, too.

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Yes, I just completed participating in the GLYX-13 Phase IIc study. I received the therapeutic dose each week for 7 weeks. Then, beginning with week 8, I was selected (double blind) to go through a phased withdrawal for the remaining 10 weeks (the study lasted a total of 17 weeks). The withdrawal phase involved receiving 1 therapeutic dose the first week, then skipping 2 doses over the next 2 weeks (placebo). I withdrew from the study after week 15 because I couldn't take the severe headaches that were seemingly caused by the on-again/off-again regimen.
The first 7 weeks were remarkable, in that I seemed to completely lose the depression. After 6 weeks after leaving the study, I'm still in what I would call "remission". The following 5 weeks during withdrawal however, were pure hell.

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@ John- I was in a Ketamine infusion study in Chicago suburbs 2 summers ago. Took me until after the 3rd infusion in the week before I responded and then it worked like MAGIC!! It was truly amazing. After that I was able to sustain the remission with one infusion per week. Then the study was over and I crashed. Doing better now with add-on Geodon and weekly therapy. Still wish I could feel like I did with the Ket. The world was my oyster. DON'T GIVE UP! Tell Dr. Feifel. 0.5 mg/kg dosing, M-W-F. The miracle! Serious. Good luck, get back and tell what Feifel says!

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I had my third infusion on Monday. I have felt nothing, unfortunately. I am in the study in Chicago. I am glad to know you are having a response. Please keep us posted!

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I just had my 2nd dose of Glyx=13 in a study in Princeton New Jersey. I felt better immediately after each dose but it kind of faded. I think this is because I have let aspects of my life go and was confronted with that while in a better mood.

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Oh, and I've been told the open label study for glyx-13 is expected to start in Feb. 2014 and continue until FDA approval.

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Is there anyone here who has been in the glyx-13 studies? I have had two infusions to date. My previous posts seem to have disappeared (?)

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Is the Glyx-13 study in Chicago at what used to be called Northwest Community? Addison and Central?

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Hi John,

I can tell you that I really felt no response after the first infusion of the NMDA study drug I was on (AZD6765), but I did start to feel a noticeable improvement in mood after the second infusion. I was enrolled at a study site in San Diego.

It could be that these new NMDA drugs work in a significantly different way than ketamine, but I just wanted to let you know what my experience was.

Astra Zeneca, the study sponsor, is supposedly going to start an open-label study once the data from the study I was in is processed and analyzed. It's probably going to be posted on clinicaltrials.gov when they're getting ready to start.

Hang in there. I think there's going to be a lot of stuff happening with these new drugs in the next few years. As one of the study docs said to me, this is cutting-edge medicine.

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hi guys. i'm 'john' from the original thread on ketamine. i think i was the first to post on that thread...

i am still alive. in deep depression though. so, it was a good surprise that a new thread was started off the original postings.

not sure why i am posting except to say that reading all your posts brought some hope. you can read my experience with ketamine in the other thread. i only had one infusion.

my question is; anybody here have a response after more than one infusion, when the first infusion did not work? dr feifel down in san diego told me that if a person does not respond to the first infusion, there is little chance of responding to multiple infusions. i am hoping since last year this may have changed since i was one of th first that he treated at his clinic.

i alos sent a email off to dr fiefel after reading all of this. have not heard back. i will report here what he tells me. he must now have a better idea i would hope about the ketamine infusions and protocol.

also, just to add; dr feifel uses no anesthesiologist when he does his infusions. just a nurse. he is very easy to work with compared to my ect doc at ucla who requires not only a lot more money, but much more paperwork, tests, etc.

i look forward to reading more. hoping we all can find some peace.

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I was accepted for the GLYX-13 trial in Chicago, but they told me I would have to wash out most of my AD meds and be without for 3 weeks and since I am having some success with my current regimen, I did not want to suffer that long with nothing just to get in the trial. When I did the Ketamine infusion study they did not require me to get off any meds, but I was on different meds at that time (about a year ago). I wanted to second the vote for therapy, I have been having some success with that as well because my issues are, I believe, brain-chemistry based as well as poor coping mechanisms developed to help me deal with early life trauma. In fact, trauma itself causes brain chemistry changes. My anxiety levels are way down and I am less reactive emotionally to episodes which would have sent me to bed for days before I started therapy. I look forward to the day when these currently experimental drugs are widely available, in the meantime I am going to continue with the therapy and the drug that really helped me which was Geodon added to my AD and other meds being taken for depression. I am still very interested in the GLYX-13 trials as well as any others being conducted to eradicate this scourge that has taken years from my life as well as all of you out there.

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Paula,

You said that the ketamine you were given during the study worked, but it sounds like the same dose of ketamine given to you at the doctor's office didn't. Any theories as to why?

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