Prolia Side Effects Duration (Page 9)
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Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happen?

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Re: Maritere (# 139)
I am sorry that you are a fellow breast cancer survivor but the good news is we did survive. Prolia is not used as chemotherapy under it's other name. It is to build up bone quickly in people that the chemo has ruined their bones so they will not suffer a spinal collapse or another very nasty side bone side effect from chemo. They get more of the active ingredient than we do is the only difference between Prolia and Xgeva. Both are to build up bones. There are specific eye drops that contain Prednisone. I'm not sure I have it spelled correctly "Prednisonioli". I had to take it when I had surgery on my macula. I had that one as an anti-inflammatory, one for dilating and an anti-bacterial. Mine was from a retinal surgeon but any can Rx drugs in the US. I distinctly remember having to go off of the Pred. drops slowly after he was sure I had no more inflammation. It does exist and you should be able to have it. Prednisone can be a very safe drug if it is stopped correctly which means slowly tapering off. I know all about the skin, hair and nails. No longer healthy and nice. Be well~Pood

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Re: Rosemarie (# 144)
No, No, No. Prolia does not stay in your system forever. A tiny molecule will be left but it's not enough to hurt you any more than that aspirin you had 20 years ago. They are both made from products from our Earth. Prolia clears out of the human body in 6 months. The half life is 16 days so that means in 16 days 1/2 of the Prolia injection leaves then in another 16 days 1/2 of that remaining half until we reach the end of the 5th month. That does not mean that the side effects leave with it. Some side effects do and others linger for years as our bodies try to repair the damage done to it. This is the first year I have been able to have any gluten since my injection years ago. I guess it just finally got over it but it sure took an awful long time. The muscle/tendon in my neck is no longer sore either. It finally left too. I did get the back fractures from stopping it. Everything in there is a total mess now that I don't pay that much attention to it. Be well~Pood

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Re: Nikki (# 149)
You will be the second one here if you do have rotator cuff tear. The other lady's is pretty much inoperable because it involves two tendons. Maybe she can do stem cell therapy to heal them. And, it had to be in a very bad spot and involved her heart too. YIKES!! Pood

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Re: Ann (# 143)
If you stopped the Prolia, you do get back fractures. That is even in their literature. I sure got them. Be well~Pood

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Re: Shirley (# 153)

Did you know also, they specifically excluded people with compromised immune systems from the test? So how in the heck can they feel comfortable giving that to anyone who has had Chemo, or HIV, or old age? This is a death drug.

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Re: Nikki (# 149)

I am sorry you and so many others are going through this ordeal. I also had x-rays of knees and CT of my back resulting in useless physical therapy. I will encourage you to follow through with ANYTHING you think might help. I started having these symptoms with Zometa and that is why the Dr changed me to the Prolia. I too, had ER+ breast cancer and was prescribed Arimidex, another drug that blocks estrogen. The lack of estrogen, especially in women, increases the risks of osteoporosis. So we are being treated with one drug to "fix" what another drug is causing. Until I started piecing things together and doing research, I was and still am wondering what I have gotten myself into. After starting the Arimidex my cholesterol went up. Once changing over to Prolia....my cholesterol is now OVER 300! I was being prescribed antibiotics (Levaquin, which is trouble in itself) every 6-8 weeks after finishing a round. One ENT told me the arimidex could lower my immunity, Oncologist said he must have been thinking I was talking about chemotherapy and that Arimidex would NOT lower immunity. Hmmmm....do doctors ever read the package inserts to the drugs they prescribe??? On my own, (without Dr's consent) I stopped the Arimidex. I was not aware of the pain I had been in just because of that drug. So he prescribed a different drug to take the place of the Arimidex.

Then after I checked with the pharmacy and found out the medicine was going to cost over $110 for a one month supply, I said, "Uh-uh!!" Around about that time I thought....... if I don't take something to lower my estrogen then I will not be "required" to take anything to "build up" my bones. I am in NO way suggesting that you stop any of your medicines or go against your doctor's orders. I am just, without making yourself paranoid, pay close attention to what your body is telling you. You have only this one body on this earth. I was given my body to take care of and I am the only one who lives in it. I see the oncologist again in March. I don't know what I may be up against when I say I don't want anything else. My breast CA was Class 1. I know that this Cancer is more apt to come back in bone than anywhere else, but taking these medicines does not absolutely prevent it either. Two years after I had bilateral mastectomy I had a total thyroidectomy for Thyroid CA. I truly wish each of you improvement of any physical and/or emotional pain This drug has caused. One more thing, from what I have read, and please someone correct me if I am wrong, but out of ALL the thousands of people who were in the trial studies... NONE "0" complained of the severe bone, joint and muscle pain. FDA got these complaints AFTER the drug got put on the market.....WHAT?

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Re: Barb (# 145)

Barb,
High cholesterol is one of the side effects of Prolia. I now have it when it was never an issue before. I'm praying since I'm off Prolia it will resolve on its own. Sending you hugs and prayers for a full recovery.

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Re: Shirley (# 147)

Hi Shirley, I also have been experiencing all over body pain and joint pain after my 4th shot in December 2017. I think I am going to stop the prolia. I have been on the heating pad and tylenol. It does scare me to go off of it but scared to stay on it.

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Re: BB (# 18)

Yes. I only had two shots and was stopped because of breathing problems. It has been over two years since the last shot and I am still experiencing breathing problems.

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Re: Alice Allen (# 140)

My regular doctor says my left shoulder problems stem from a rotator cuff issue. Waiting to hear if the x-rays reveal anything.

I just had two x-rays on my lower back for constant pain. My lower back hurt before but it has increasingly gotten worse. My first suspicion is the Prolia. Do you think I'm wrong? Has anyone else had these problems? I take Plaquenil for osteo and inflammatory arthritis and I have fibromyalgia.

Thanks y'all so much for the help.

Hugs,
Nikki

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Re: Katherine (# 9)

I. Had. My 4th. Prolia. Shot in. December. And I now have pain all over my body l have decided stop the prolia. Going to. Seek alternative and do accupuncture for the pain. Glad your mom is doing better

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Re: Barb (# 145)

Yes, I believe it does. I saw my GP for severe bladder spasms she started treating me for UTI . But the culture did not have any bacteria growth. That did subside after about 7 days, but the joint and WHOLE body pain is almost unbearable. It has been a month since my last, and I do mean LAST injection. Can't deal.

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Yes, I would like to know the answer to that question!

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I had my first prolia injection in October. I have had increased pain but also constant burning while urinating and frequency to urinate but no urinary tract bacterial infection but my WBC count in the urine is elevated. Have had other tests to test for bladder cancer. I also take exemestane for breast cancer . I feel like prolia has made me already more miserable than I was. And now I have high blood pressure and high cholesterol, which I never had before. Can prolia be causing all of this???

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Omg, reading all these side effects is scary, especially now knowing that prolia stays in our system forever. My arms are so sore that I can’t lift them and ache so much in bed that I’m unable to have a good nights sleep. Now have developed pain in the lower right side of my back that makes it Increasingly difficult to stand right away from sitting position. Seems something else is developing everyday other day. I’ve had 2 injections, won’t be going back for the third. Please anyone considering taking it do your homework first.

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Re: teddt (# 142)

I have rheumatoid arthritis. I also read that it had not been tested on people with this problem but my dr. gave it to me anyway .
It has destroyed my ligaments in my hands and feet. Now I have a fractured back. I took this shot in May of 2016. I had none of these problems before and I was doing great.. Dr.'s won't believe that Prolia is causing it. I think they may believe but they won't comment.

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Re: Maritere (# 139)

Thanks for sharing. My wife already had a compromised immune system, and yet they assured us it was no problem. Now we find out, Amgen never tested those with my wife's issue on their drug study. As a matter of fact they were excluded from testing. Well, medicare pays those Dr.'s $1600.00 for that shot. No wonder they don't want to give up that income.

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Re: Maritere (# 139)

There was information in this post about Prolia I wasn't aware of. Thank you so much for sharing.

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Re: Gloria Varnadeau (# 15)

I have taken Prolia for 5 years my Magnesium bottomed our The side effects has hit my muscles my legs are so week my jawbone hurts have lost two teeth I have been told by two doctors you should not take Prolia more than two years also that the muscle damage is irreversible this Prolia shots have ruined my life we have to fight to get it pulled off the market we are suffering while the drug company gets filthy rich

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Re: Bunny (# 108)

Congratulations to you for doing what I usually did until I made the mistake of following my Dr.'s advice without researching this horrible drug.

I had my first and only Prolia shot on the 30th of March, 2017. Four days later I was at the Emergency Dept. of a local hospital here (Im in Canada). I had an autoimmune response that included severe erythema lesions on my legs, feet and elbows. The pain was unbearable and I could not walk. My husband had to take me to the hospital in a wheelchair. Nobody at the hospital (and I saw three different MD´s) wanted to write the word "Prolia" in my file. The three of them told me that it could have been "anything"... I asked them to write it at least as a hypothesis... (a month later, however, when I requested a copy of my file, the reference to this poison was nowhere written). Three weeks after the inj., I had lost 20 pounds and was loosing my hair, my heart was racing all day and I was suffering from extreme fatigue. At that point I went to see my GP who had prescribed this poison and told him what I thought. He told me he had “many, many patients on Prolia and nobody had had any side effects”. What I found quite curious is that the Dr. had kept a list with the names of all the patients he had prescribed Prolia to. He showed it to me emphasizing that I was the only one who had had these reactions. I told him that I thought I was “lucky enough” to have had these reactions immediately after the first shot while many might have had several shots before they had a severe reaction. Perhaps many out there who have had reactions do not associate them to this poison because these reactions did not happen immediately after the first shot.

I had breast cancer 6 years before Prolia and I realize that my Dr. should have never given me this inj. (now that I understand how these monoclonal antibodies type of drugs work in your immune system). When I had cancer I did not want to have chemo. I chose to do immunotherapy. The goal was to increase my T-killer cell count and strengthen my immune system. I won that battle and after my 5th year post-cancer, I was not only cancer-free but healthier than ever. My skin, my hair, my mood, and my whole health had never been better. I went back to my gym 5 days a week, had a perfect weight and when I turned 60 early this year, nobody could believe my age. I then had the bad idea of having my yearly check-up and listening to my GP when he suggested that I underwent a densitometry to later insist that I should use Prolia. I must have been in the 10 most stupid minutes of my life when I accepted this poison without having done my own research! It was so totally different to what I did when I was diagnosed with cancer! When I understood how Prolia works, I cried for days, realizing that I had been given a drug that is used as chemotherapy and that also causes your T-cell count to go down and go totally crazy. In addition, In order to get rid of the erythema on my body, I had to be treated with Prednisone, a corticosteroid that leaves you immune-depressed… I was living a total nightmare. Despite the nightmare, in the middle of July I was feeling slightly better and had partially recovered my weight. I travelled to South America and shortly before my trip I felt that the whole cycle was beginning again. But I had my ticket and still felt well enough to travel.

Shortly after my arrival there, I was having palpitations, was feeling extremely tired and my hands were shaky… I had to urgently see a Dr. who immediately diagnosed me with hyperthyroidism. I was put on two medications and only started to feel better and regain my weight about two or three weeks later. In the month of September, when the thyroid medication had already been reduced and I was feeling quite well again, we were celebrating my daughter`s B-day when everyone noticed my eyes were swollen. I have seen at least three Ophthalmologists since. None of them seemed to care about my story. I have been told that having swollen eyelids happens with age (LOL), that I need artificial tear drops because my eyes are too dry, etc…. Fortunately I have been in touch with the Endocrinologist I saw in South America. He believes that I have Graves Ophtalmopathy, probably as part of the whole autoimmune response to Prolia and that unfortunately, this tends to run parallel to the thyroid disorder. In other words, it may not automatically correct itself even if the thyroid is well controlled. He believes it is imperative that I am treated with Corticosteroids to prevent the eyes from popping out… which has not yet happened as only my eye lids are now severely swollen but the eye globes seem to still be contained... I`m desperately trying to find a reasonable Dr. who would put me on Prednisone or another immune-suppressor, as I realize I have no other option. It is not only a horrible condition aesthetically speaking, but is also causing vision problems as I have diplopia and photophobia….

Please, if anyone in this group has had the ophthalmic problem associated with the thyroiditis following the use of Prolia, could you please share the name of the medication that has been given to you for this and the actual prescribed dosage?

October 30th was the 6th month anniversary since my life was transformed by this horrible “medication”. I look like 10 years older than 6 months ago. What used to be my beautiful hair, is falling out, as I have only seen in cancer patients who are undergoing chemo.

I agree fully with those of you who have said this drug works in cycles…. That is what I have experienced. I currently am again experiencing fatigue, insomnia, and strange ‘migratory’ pain in the bones, even though I had a couple of pretty good months between July and September.

Lately, my spine makes strange noises when I move and I have the feeling that I`m extremely fragile. My nails, which had become very nice and strong in the first few months after Prolia, have again become extremely fragile and brittle. My skin goes through periods of being nice and soft and days or weeks of being rough, ugly and dry.

I never thought 2017 would be so horrible for me because of this drug. I retired from my permanent job two years ago and was beginning a new and very successful cycle as a self-employed professional. I have hardly been able to work since March.

I feel we have been used for a clinical trial without our consent. If you look at AMGEN's website, you will see that the list of negative side effects for this drug is continuously being updated…. Isn’t that a proof that they had not fully researched what they had put in the market? I hope we are at least compensated for the objective losses that we have incurred because of this killer drug.

I hope that my long message helps you and other potential users of this poison to not run the risk. All medications have a level of risk, we know that, but the risks of this one out-weight by far the potential benefits, if any.

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