Lisinopril & Grapefruit? (Top voted first)

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Are there food restrictions such as grapefruit when taking lisinopril?

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11

I am taking lisinopril and hyrochlorothiazide 20/25 mg can I also eat grape fruit while taking this medication??

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4

I worked in health care for years & was never told of an interaction. My husband LOVES grapefruit but has started taking Lisinopril & had severe pains, shortness of breath, & spikeing blood pressure, sweating & vomiting. We had to rush him to the urgent care center near his work when he had an episode & they gave him 2 nitro pills under his tongue & made him chew asprin. 3 hours later they let us leave but ordered stress tests for him to have done in 2 days. He had the tests done & they said that he was fine, they could find no cause for the episode & follow up with our regular dr. The Dr couldn't understand how he could not have any new issues after the episode. My husband had a friend stop over to check on him & happened to see my husband peeling a grapefruit, he started having a fit! He happenes to take the same dose of Lisinopril that my husband takes & HIS dr gave him a list of things he couldn't eat or take & lo and behold grapefruit is on the list. We took a copy of it to our Dr & they confirmed that he in fact should not have been eating grapefruit & someone in their office SHOULD have given him a similar list along with his prescription. I am so glad we found out before it was too late.

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20

Actually.... ANY citrus fruits cannot and should not be eaten while on Lisinopril as they contain potassium. lisinopril retains potassium and too much build up in the system can put someone in renal (kidney) failure fast! I was given a specific list of potassium rich foods to avoid while taking this drug.

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13

1. Neither Lisinopril nor Hydrochlorthiazide show an interaction with Grapefruit juice.

2. Neither Lisinopril nor Hydrochlorthiazide are metabolized by your liver (or any other organ for that matter) so you are doing NOTHING for your liver by not taking a drug which you were prescribed for a purpose. You should not stop taking your BP meds!

If you want to cleanse your liver, get some exercise, lose weight, quit drinking alcohol and stop taking acetominophen.

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6

What constituent of Grapefruit, or its juice is responsible
for the general elevation of the effect (desired), of grapefruit on certain meds; and just how harmful can some of these meds be when taken concommitantly to this fruit. A list of the most reactive drugs, please.
Tnx.

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10

It is not a "side effect" and it does not "react with the medications". What Grapefruit juice does is interfere with an enzyme that is involved in breaking down *certain* drugs thus causing the serum level of the drug to be higher than expected for a given dosage. So.... it would be similar to taking more Lisinopril and more Metformin... However! There is no evidence that the enzyme (CYP3A4) is involved in the normal breakdown of either Lisinopril or Metformin so, it should have no effect whatsoever! (other than psychosomatic or placebo)

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7

There is no conceivable relationship between your husband's eating of grapefruit and his symptoms. That is not to say that grapefruit would not increase the apparent dosage of Lisinopril, however those symptoms are not consistent with an "overdose" of Lisinopril, which in any event would certainly require more that just eating grapefruit. In fact some people (myself) eat grapefruit with the express purpose of increasing the absorption of some medications. In my case that happens to also include Lisinopril.

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16

My roommate is out of lisinopril, i take topril 25 mg, can he take this medication. Looking for a professional opinion?

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17

lisinopril is FREE in many pharmacies with a prescription, as are many antibiotics and metformin, a diabetic medicine....being out is silly, just contact the doctor for a refill and find a participating pharmacy.
Try target or Walmart.

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19

Lisinopril and Metformin are free at Publix

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25

I am a Nationally Certified Senior Pharmacy Technician. Among my many duties in the pharmacy, I worked one on one with patients to ascertain any side effects to their medications as well as the efficacy of their meds. I worked mostly with those on high blood pressure medications, oral meds for diabetes and clients on HIV regimen therapies. I also attended weekly meetings with Pharmaceutical reps to discuss the results. My husband was on propranolol only for HBP until lisinopril was added. I was amazed when his doctor started testing his potassium levels every month because of the possibility of his potassium levels becoming too high. (I myself have a hereditary condition where my potassium level remains low, sometimes causing temporary paralysis. I mention this because the symptoms your husband exhibited, I experienced after receiving too much potassium in the hospital. They knew right away. They had me on a heart monitor just in case while I was receiving my IV K installations, because too much potassium can cause erratic pulse, blood pressure, heart palpitations, chest pain, profuse sweating even dizziness and fainting spells.) They gave him a list of foods not to eat with 2 hours of taking lisinopril, all containing citrus, which contains potassium. I took that list into work and shared it with my Lead Pharmacist. I found out at the time it was not mandatory to put a label on the prescription bottle to warn about citrus. Now, we are required by law to warn clients about any potassium retaining medication and the citrus/potassium interaction. There are mixed feelings about this in the medical community, but the doctors and nurses do not usually have the same kind of relationship with medications and clients like pharmacy personnel have or the same knowledge. It sounds like your husband's potassium levels spiked. Everyone has a baseline and the levels could be within normally acceptable limits and still be too low or too high for that person. My husband takes his blood pressure meds at night, so he can have his grapefruit in the morning, and his potassium levels haven't dropped or spiked. Get to know how any blood pressure med or diuretic affects potassium levels. A GP may not know the answer but a Cardiologist or Nephrologist should be able to answer your questions and give you informative sheets. Good luck!

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8

Can Grapefruit infer with Lisinopril and Hydrochlorithiazide

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9

Metformin and Lisinopril and greatfruit juice

I am a 52 YOA, W/M, red hair & frickles, 6' 2", 220 lbs and I just started taking Metformin 1000mg for type 2 diabetes and taking Lisinopril 5mg for high blood pressure.
And I have 2 greatfruit trees, one a pink greatfruit and the other a Duncan greatfruit tree. I, too have heard that greatfruit can produce side-effects that react with both medications.
So, I had 3 glasses of pink greatfruit juice over a day and half, breakfast, lunch & breakfast.....the results were mild, not that bad, but enough to where I won't be drinking anymore greatfruit juice with my medications.
I think the reactions are different for everyone.
It felt that it stimulated the lisinopril and improved it's effects, but it felt as though it interfered with the metfomin, as my glc was higher.
I posted my stats, so the effects, I think, are different for each person.

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21

good grief. err on the side of caution. please check out this article on webmd.

webmd.com/hypertension-high-blood-pressure/guide/grapefruit-juice-and-medication

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22

The juice itself stops certain enzymes in your intestines from inactivating a portion of the medicine. As a result, too much active medicine makes it into your bloodstream. The symptoms are basically that of a temporary overdose.

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23

I loved grapefruit. But after taking more neds abd one time a statin. I just stopped eating and drinking anything w grapefruit. There are too many meds that it may affect. Just playing it safe .

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24

What can't I eat or drink with lisinopril

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26

I take lisinopril 10 mg and eat apples with skin because I've heard that it helps cholesterol levels. Is it ok to do that? Can someone let me know?

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27

I take Lisinopril and Met Forman and just reasently been having pressure in my chest. I also just been started eating grapefruit after several years. I really believe that it is because of the grapefruit. The gent above is correct I believe. The three do not go together. I also believe that the results are different for each individual. However this is just MY opinion. Not fact based. Consult your physician always.

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12

I am taking Lisinopril/HCTZ 20/12.5mg and I want to do a liver cleanse that requires me to take Grapefruit juice as part of the cleanse. Can I stop taking my Lisinopril for a couple days prior to doing the cleanse and then resume when it is complete which is a one day cleanse without having possible effects from the grapefruit with the medication?

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