Ozempic Forum
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I have been on Ozempic now for 5 weeks. I started at the .25mg and after two weeks, upped it to the 0.5mg. I have never felt so dang good! I'm 53, post-meno, non-diabetic, 5'4", and SW was 264. My current weight, after just one month was down 19lbs! Now I'm down 21lbs! I'd love to finally be 165lbs or so again. I haven't been that small since I was about 11 years old.

Ozempic has saved me! I can't believe it. I actually look forward to the injection every week. I only had nausea for a little bit the day after I started. And since, then, it's been great! No diarrhea, no nausea, just boundless energy.

And not just that, but it's done something to my brain! I have this amazing sense of optimism, and positivity. I feel hopeful again! I feel like I AM going to finally lose this miserable weight.

I don't have much hunger. This stuff makes me NOT want junk food! It's a damn miracle, I tell you! I WANT to eat healthy stuff now. How did this happen?! LOL! I crave lettuce and raw broccoli, and carrots, and good steak. I hardly eat any breads or biscuits, haven't had any cookies or cake. I did have one small tiny little container of Blue Bunny vanilla ice cream. The kind in the little 1/4 cup containers that you buy. I think they come 10 to a pack? Five vanilla, five chocolate... And I'm also snacking on healthy nuts. Walnuts, pecans, pumpkin seeds and pistachios.

I am so happy!! Let the weight loss continue! The struggle before was real. And now, I feel euphoric and I just KNOW I'm finally going to be able to wear clothes out of the regular section of the store, not the damn plus sized 2X and 3X options!!

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Re: VerFree (# 1)

I have been on Ozempic for diabetes and my numbers are better than they have ever been. I do have nausea and feeling sick to my stomach. And my desire to eat has decreased

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Re: sandy (# 54)

GLP-1s can also treat things like:
-- drug resistant depression and anxiety.
--treat or even save peoples kidneys with CKD.
-- treat some types of lymphomas and leukemias.
-- Treat certain skin conditions

You may not agree with it being used as a weight loss drug. But probably would in the case where someones weight is significant enough to become or already is a significant health issue. Most people morbidly obese have a biological cause that can't be overcome by just diet and exercise.

cAMP is a secondary messenger that is involved in a multitude of functions of the body. These drugs work under the covers by accumulating it. Mounjaro is better than Ozempic, because it increases cAMP levels even better. Which is responsible for it's effects for diabetes and weight loss. As well as the other things I listed.

I know we associate it as a diabetes treatment. But really, that is just one of several things it can treat.

Does have a dark side though. Which drug companies are all too happy to hide. I predict a black box warning many many years down the road when the FDA gets their head out of their....
--Some people have the opposite cognitive response and it shuts down PFC signalling efficiency. Typically people would describe it as brain fog. someone dependent on Bi-Polar meds may end up hospitalized to renormalize neurotransmitter levels. While others were able to reduce their bi-polar meds and stop drugs for comorbid anxiety and depression altogether.
Me, dependent on ADHD meds, had the negative response and destroyed what Adderall hadn't already of my life with its side effects. Had to learn enough neurology to find guanfacine can fix that for at least some affected, like myself. But after damage was done trying to over come the issue on not lose my job via higher Adderall doses.
--Potent CYP3A4 inducer. Their misleading petri dish liver enzyme tests do not test the actual method that it induces 3A4 activity. Probably ok for most people. Not me with 5 medications metabolized by it and a vitamin A issue affected by it. Very difficult trying to get things balanced again with crap doctor ignoring the issue (long story).
--They love to scapegoat delayed gastric emptying for medication issues. Easily proven false when having all the peripheral side effects of Adderall and less than no therapeutic effect in the brain. And especially when combining guanfacine and mounjaro and that actually enhanced my ADHD meds therapeutic affect. Could not be true if delayed gastric emptying was more than it really is. Now, I pound meds with 20+ oz water and since water passes through stomach, takes meds with it. But have to keep bottom right of stomach where it empties the lowest point as meds sink. So, stay vertical, or lay on right side. Laying on left side and adderall gets ionized and performed poorly. And other mades may be spread out making their peak effects flattened and not strong enough.
--Some can have debilitating nausea. Certain forms of Dramamine products have been found to help.
--PDE inhibitors can potentially have synergistic effect with GLP-1s. Started Cialis (PDE-5 inhibitor) for Adderall side effects same day as Mounjaro so never realized it till I stopped Cialis and Mounjaro and other meds I take had a functional decline. And other things like eye sight affected. PDE5 is important in eye health, etc.

Told my doc, I think Mounjaro saved my kidneys, didn't believe me. 3 years later it is approved and a treatment for kidney disease. I take Jardiance also that is also a treatment now. But it was not working till I added GLP-1 support.

So, far more to these meds than people are made aware of, or in info made available to doctors even.

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That is so wonderful! It's encouraging, inspiring and a delight to hear your story. I too am losing weight once again being on trulicity. I had to go up to the highest dose for it to be effective again but so far down 17 lb in a couple months. I have quite a weakness for chocolate and so a thing for chocolate ice cream. I switched to the low carb low sugar option in the same brand and it's really good. It's almost got into the point where the regular chocolate is too rich for me. It's been wonderful to see the way I snack or way way down. I just don't have those cravings and I get to have time to think about what I'm going to eat before I just grab something cuz I'm starving. Even if I'm hungry I can put it off for a little bit so it's now more like meals every 5 to 6 hours as it should be. Thanks for sharing your story. I wish you the very best! You're doing great!

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Re: HCStymie (# 57)

At my age old as dirt! I won't worry about Ozempic I will go when the good Lord says it's my time! and I feel great don't have any of the problems you suggest! so keep your thoughts quiet unless you have these systems!

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CONGRATS!!!!!! I hope all your dreams come true.

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Re: sandy (# 55)

I have come back to up date been on Ozempic it was one year March 12th 2026 I feel great! when I started Ozempic my A1C was 7 point something took 36 units of Lantus mornings 16 units evenings went down to 28 units mornings my evening units had to be cut down! now here it is April 9th,2026 MY A1C IS NOW 5.5 had to cut my morning units of Lantus to 28 units down to 23 getting to much insulin no units at night this happened back aways I have lost a total of weight 40 lbs in one year went from 194 lbs now 154 want to get down to 124 lbs i'm only 4'11 I don't have any problems with Ozempic! feel great!

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If you want to know what it does to your brain, look up research on increasing intracellular cAMP in the brain.

GLP-1s have had clinical trials for this effect as a second line medication for drug resistant anxiety and depression. For others not depressed or with anxiety, it may just be stimulating and have positive mood benefits. Even after factoring in psychological factors of weight loss and/or diabetes under control etc.

Note, cAMP has positive and negative effects on the brain at the same time. It is the net affect that people see which idiosyncratically can be the full spectrum from very positive to neutral to devastatingly negative. I think the negative response is the least often but can't be sure as drug companies are actively trying to hide the fact that it can do that.

I say "devastatingly" in the context of someone dependent on psychoactive drugs who all of a sudden have the signalling in their PFC shut down and can be even worse on the drugs than even what withdrawal would have been if they just stopped taking them (my experience). But, for people not dependent on psychoactive meds with the negative net effect, is "brain fog" and can choose to stop taking it.

Examples from those who are bi-polar. Some have been able to take less bi-polar meds while actually stopping their meds for comorbid anxiety and depression. Which is a massive benefit. Some had neutral effect. Those on the far negative spectrum, were hospitalized to rebalance neurotransmitters while under psychiatric observation. Which is the black box warning I predict in a decade or 2 when the FDA gets their head out of their.....

**If anyone has a very negative response, guanfacine may be able to turn it around and make it positive or at least neutral within a few days. Skipping the cAMP neurology and GLP-1 drug design lessons. Tested it on myself and reversed the negative effect to positive while still having positive benefit in other brain areas making it hugely net positive, after destroying my life already. But, things got real quirky from there but that is a whole other subject. Have been back on for 2 years and counting though.

Key takeaway, if response is cognitively intolerable or may be looking at potential hospitalization, and therapist doesn't see a contradiction for guanfacine. Then, maybe give it a try and potentially spare yourself having to go through it all or even in a hopeful case, avoid the hospitalization if on the far negative side with dependence on meds that would be devastating to be blocked or worse, below withdrawal level of activity. Won't work for everyone. 3 people I know tried the combo. Me (ADHD, SCT, Narcolepsy), most negative on GLP-1, yet most positive response with guanfacine added. Friend (ADHD, possible mild SCT) who was neutral on GLP-1, had significant benefit adding guanfacine, but not a huge benefit like myself. Other friend (ADHD, very likely SCT, anxiety) with less negative response, still had negative response adding guanfacine, but was able to manage it before giving up. He may try to titrate to see if there is an effective response range for him, after he finishes studies to become a doctor as not a good time in middle of studies to experiment.

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Re: sandy (# 54)

I'm type 2 Diabetic since 1996

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Re: Pk (# 44)

This thread has nothing to do with politics or trump

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Re: Pk (# 44)

people that aren't diabetics shouldn't be taken Ozempic

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Re: DEE (# 50)

Have to talk with a DR about the skin!

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Re: DEE (# 49)

If you had a lot of weight to lose of course one's skin will loosen up and skin get wrinkles, it's only logical

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Re: Janean (# 9)

I'm so happy for you that you are getting good results with your blood sugar. Maybe try to be happy for those who feel they would never find a way out of their weight gain also.

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Does anyone know of a medication for the skin issues from taking osympic.

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I took ozempic for 5 weeks. The first week I was so constipated. Second week I started with nausea all day then I started having diarrhea it lasted for 5 weeks. It caused me to be dehydrated. My Dr. took me off of Ozempic. I had lost 44 lbs. About a week later I noticed the crepy and loose skin on my arms and neck and wrinkles on my face. I'm grateful for the weight loss but not for my skin issues.

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Re: Happychick (# 3)

I have been on Ozempic 5 days and hungry all the time could you give me meal suggestions please?

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Re: Lydia (# 16)

yes, it will slow down, do not get discouraged. I have been on it since July, I wanted to lose 1 pound a week, I figure that was safe. You are losing a lot at first, water weight, and have you ever lost weight before, your age could have something to do as well. Younger you are easier you lose. Once you start to get exercise and gain some muscle it will change. Just go with it. Find a good Salivation Army or Thrift store for your clothes, don't hang on to them. But your new clothes there as well, do not waste money till you make your goal, then don't go crazy, pants are the things I had to change size a lot, I had my brother put new holes in my belts. I bought pull on pants nothing fitted yet. My legs are very thin like chicken legs, so I need to get them toned up. I wanted to get to 160, I'm there, now I am going for 145, I have never been a size 10, I am just going into 12 I am happy to go to regular sizes BUT size 12 never has anything, everybody is size 12 I guess.

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I am having sweet cravings, I am not a sweet eater, my thing was carbs. BREAD

I have a square of dark chocolate when I get the craving. I eat other things like roasted sweet potato and carrots, salads when I go out because I hate to make them. I started in in July and as of March 4th I am down 41 pounds. I was walking over 10k steps at work in a high school, substituting, that is not happening now. I have a gym membership, and I need to go for strength in arms, I used to be really strong and swimmer. My town is very small, no pool. But great walking, I just can't get motivated. Does anyone else crave chocolate or sweets?

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I have an 8mg Ozempic pen but only need to take a 1mg dose. Can anyone tell me how many clicks on the pen I need to only administer the 1mg dose? Really appreciate any help with this question.

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Re: Janean (# 9)

I think it’s disgusting that people use Ozempic for just weight loss. As it does affects the people who need it for diabetes. But people are selfish that’s why they voted for trump.birds of a feather so they say.

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