Mounjaro Side Effects
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This is my 4th month on Mounjaro and my 1st month on the 7.5 mg. My A1C is 5.7, down from 10. It is working great but the side effects from the 7.5 mg are rough. Extreme nausea, vomiting and diarrhea. My doctor wants me to increase to 10 mg but I can barely handle the 7.5 mg. Has anyone else experienced these side effects and do they eventually go away?

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I've worked my way up to Mounjaro 12.5 starting on 10/11/24 after being on 10 for about 9 months. Started at 7mg just over a year ago. Side effects have never been an issue for me. No nausea ever. Loss of appetite, and not even remembering to think about eating, is what I expected with a weight loss shot. I do have a lot of belching and heartburn at night because the stomach empties very slowly. (I take a Prilosec as needed) I notice a few things- I must drink more fluids as I am very dehydrated. I must pick healthier choices for a meal or snack because I notice high sugar/fat/simple carbs food will make me feel sick. Never vomited. I also take a high quality B Complex vitamin every day which helps with my "brain function" and nerve or joint pain. (I can't tell which it is)

HOWEVER- now that I'm 3 weeks into 12.5mg, I notice worsening diarrhea after experiencing constipation on the lower doses. If this doesn't adjust back after my 4th shot in 3 days, I will try Imodium and talk with my doc. I may need to go back to 10 to get rid of this gut rumbling and at times uncontrollable squirts. (sorry). Let me emphasize NO PAIN though. I have lost 31 pounds since I started this and my A1C went from 7.6 to 6.9. Next labs in Feb 2025.

As an aside, I was on Ozempic over a year before I started the Mounjaro and for about 8 months. That shot made me very ill with nausea always and vomiting, many times with no warning. It was terrible. Mounjaro nothing like it for me.

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Re: JMD (# 15)

Late reply but for me I was also taking Adderall at the same time and both together amplify the appetite suppression of the other.

I first stopped Adderall due to damage and down-regulation from tripling my Adderall dose trying to overcome Mounjaro blocking its effects and eventually was unable to work any more (some people actually have a positive effect making their psychoactive meds work better, in the worst case some people who are bi-polar were hospitalized after starting Mounjaro to rebalance their neurotransmitters. You will not find any incidence rates for positive negative or neutral interaction with psychoactive meds as industry does not even acknowledge the effects exist. But all the self reporting and discussions on reddit do). Then I stopped Mounjaro 4 months later and went back on Adderall and added a few other drugs to offset my Adderall to a lower dose when forced back to work. Problem is even though my Adderall couldn't work while on Mounjaro, the high dose was actually damaging my brain the same as if I was not on Mounjaro so was all banged up even after stopping both drugs. Back to work on a combination of meds just continued the down-regulation and damage for 3 more months till I was unable to work anymore on combination therapy which was more effective than just Adderall or Adderall with Strattera.

Either Adderall or Mounjaro without the other obviously had less appetite control than both together. But when I had stopped both Mounjaro and Adderall, my appetite came back with a vengeance. Even when I was full I still craved food. Gained back 25 lbs before gong back on Mounjaro.

I won't get into details now, but I added Guanfacine and that mounjaro/guanfacien combo counteracts the psychoactive negative effects and is not just neutral, but also is positive and provides more benefit than any one of my other drugs alone (armodafinil (sometimes modafinil), adderall, strattera, caffeine, and a ton of supplements that have cognitive benefits. In fact guanfacine and mounjaro with out the other were both negative for me and my other meds do not even work without the mounjaro/guanfacine combo. Which also helps when I don't take those other drugs while healing my brain. You won't find research on that online. It doesn't exist yet. But you can ask your doctor to try guanfacine if it would not be harmful and see if it helps you if you are one of those negatively effected in the mental health area by Mounjaro. Be careful if a person with positive mental health side effects as Guanfacine may possibly enhance psychoactive drugs even more and be too strong at current doses. Many people have reported Mounjaro allowed them to reduce medication doses and in some cases, were able to stop comorbid drugs for things like anxiety or depression. But have yet to see someone with positive side effects report adding guanfacine after the fact so only have theory to go on.

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Re: Tina (# 19)

You may want to see if your doctor could write you a prescription for Zofram. I have had stomach surgery and get nauseated quiet a bit. It works fast as it is put under the tongue so it quickly gets into your bloodstream. Hope this helps at least a little bit! Huggs XOXO also try peppermints!

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Re: Fairy (# 27)

I too have experience being cold. I'm always hot. Since I started the Mounjaro 5 mg I have cold feet and hands. Is anyone else having this problem.

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I have been on Mounjaro for 8 months and have had itching and numbness in the armpits. Not sure if its a side effect or from the 50 lb weight loss.

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Re: Nick (# 13)

Your body has to get used to it when I first started on the 2.5 I had some nausea by the second injection. I had more nausea when I started the five I had such severe nausea I had to go to the ER to get some IV anti-nausea medication, but I kept with it and I’m now on the 7.5 I’ve been on at 5 1/2 months and I’ve lost 71 pounds as of today so if you can stick with that side effects which I know can be severe believe me, I know it’s worth it in the end .

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Re: Fran (# 6)

Switched from Ozempic to Mounjaro. 24 hours in after my first dose, I had extreme tenderness in my neck, back, face and armpits. I found on Reddit that there are a lot of people that have also had similar symptoms. I'll be calling my doc in the morning.

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I took Mounjaro .25 for 8 weeks and now in my 5th week of .5. I’ve experienced a great deal of nausea along with many of the issues that others mention. I’ve lost 25 lbs. That’s why I’m still trying for 3 more weeks. My question is about being cold. I’m usually the hottest person in the room and have been my whole life. Now I have to bundle up at night and sometimes have to put on a long sleeve shirt in the day. Wondering if anyone else experienced this?

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Re: JMD (# 15)

I was treated for a kidney infection but turns out I had no infection. I’m hoping it was just a stone and nothing else? Do you have any kidney issues while on this medication?

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Re: Wiff (# 12)

I took my 2nd 7.5 dosage last week and had gotten severe nausea and back pain. I think it turned into a kidney stone. I’m going to the doctor this week but the fatigue and nausea I’m experiencing is like no other. Also blurry vision sometimes and forgetfulness. Anyone else?

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I started the 2.5mg dosage of Mounjaro on Sunday 7/16/23. Day 1: Some slight nausea. Night 1 or Night 2 started the extreme insomnia that lasted every night. The first night by 6:30 am I hadn't slept a single minute (and I take a sleep med). Day 2: The constipation started which led to Day 3 diarrhea and continued sleeplessness. Day 4 led to throwing up hard enough it made my nose bleed. Finally, Friday I feel better. My second dose is scheduled for Sunday. When do you know to throw in the towel on a med? Are these side effects that get better or am I on the wrong path?

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Re: Fran (# 6)

Did this resolve itself? First does next morning I felt upper body aches tenderness upper back, shoulders also up neck and to the base of my skull. But my job as inpatient rehab therapist can been physically demanding at times wasn’t sure if the cause.

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I'm 66 and just did week one of Mounjaro, having the burps and gas and stomach pain. Are there any other older users having the same problems and did it subside after a while on the medicine?

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Re: Angie (# 20)

Thank you! I just need to know what may happen. I am a planner lol.

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Re: Tina (# 19)

When I have side effects, they appear 2-4 days later and last about 4 hours (vomiting and diarrhea). I stopped 7.5 for a month and have since started over with 2.5. So far, no bad side effects but no appetite suppression, either. I’m going to try 5 mg. this weekend.

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1 have had three 2.5mg Mounjaro injections. I felt nothing, but a slight constipation on the 2nd or 3rd day after. My first injection only did I feel a little not hungry. My appetite was fully back within 2 days. No weight loss, no change in glucose. The 4th week I am unsure if a flu or reaction, but day 2 this time I had very loose stool and watery diarrhea for 3 1/2 days now, as well as headaches and some chest burning. (I do have GERD, etc.) I have had a terrible experience with Ozempic so I am scared of the 5th injection on Friday. My 1st question is, when do most people get their side effects after the injection - as in minutes or hours or days? 2nd question: How long do most side effects last, as in how many hours or days? 3rd question: Is there any safe OTC option to prevent these side effects? Also, as a note: Ginger chews and mints are usually my go to other than my prescriptions. My gastrologist switched me to Metamucil rather than Benefiber since I told him about the stool combination, however I do not know if these last couple days are due to a flu or the 4th 2.5 injection.

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Re: Nick (# 13)

Try incorporating protein and a little healthy fat (like the avacado you mention) and skip the other carbs. Carbs will contribute to hypoglycemia.

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Re: lulu (# 16)

My doctor and pharmacist both say that with an increased dose, there’s a risk of unpleasant side effects which usually subside. All the best to you!

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I'm on my 2nd month of Mounjaro and am ready to start the 5mg dose, but am anxious about side effects. Wasn't too bad at the 2.5mg dose, just queasy and constipated. Type 2 diabetic just trying to lower my A1C. Will a 5mg dose increase the risk of side effects?

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Anyone have problems when stopping Mounjaro? Stomach, digestive, bladder or kidneys?

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