Glyx-13 Discussion (Page 2) (Top voted first)

There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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REPORT

From what I could gather, GLYX-13 is said to be a molecular cousin to "ketamine", inducing similar antidepressant properties without the common street drug side effects.

This info was reported from a study funded by the National Institute of Mental Health (NIMH) that was published this past April 2013 in Neuropsychopharmacology.

I think other's who may be in the following Ketamine discussion thread might also find this topic interesting as well. Was this the thread you were referring to by chance?: Discuss/Ketamine-for-Depression-231123.htm

I hope this helps!

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Yes this is it!

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Hello,

I don't know much about this topic, but I will do my best to provide some helpful and accurate information.

Based on my research, GLYX-13, is a novel and selective NMDAR partial agonist in development as an optional therapy for patients who suffer from depression and do not respond well to current therapy. According to the National Institute of Mental Health, GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the street drug side effects. GLYX-13 and Ketamine have many similarities but many differences as well. From what I can gather, Ketmaine may cause more side effects than GLYX-13 such as: delirium, dizziness, diplopia, blurred vision, and nystagmus. In clinical trials, administration of one single dose of GLYX- 13 gave extensive results in a 24 hour period, and the results lasted nearly a week. Application of GLYX- 13 is well tolerated. One of the great advances in this therapy is lack of schizophrenia- like symptoms, which have the possibility to occur in treatments with conventional NMDA receptor modulating agents.

Does anyone else have more information to provide?

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@ David yes that was the discussion I was referring to, the main focus ended up being mainly about GLYX-13 so we decided to make a separate thread for it and use that one for ketamine related questions

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I'm enrolled in a study of AZD6765, another ketamine derivative, and it's working! Best part is that the side effects are better than the SSRIs, which were awful for me.

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BlueheelerCD et al, thanks for the new thread on GLYX-13; it's definitely needed. Well, as I posted on the ketamine thread, I was not accepted for the current on-going phase 2 trial of GLYX-13, but am hoping they start another phase 2 (or 3) trial someday soon that I'll be eligible for. SSRIs and SNRIs don't work for me because I have chronic migraines and they are all migraine triggers for me. For some reason Imitrex (very common and old migraine med) was one of the reasons I was excluded from the GLYX-13 trial. I can only assume they are being extremely strict about who gets in and what meds they are on, but I cried the entire morning when I found out I didn't get in. My neurologist suggested lithium for the migraines, and my psych OK'd it because he thought it would help by depression/anxiety, tho I'm not technically "bipolar". It does seem to be helping everything except I'm taking Pepcid every day for stomach pain. We'll see!

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@daisy please send more info!

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WOW, just googling AZD6765, it appears to have a lot of promise!

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Sure, what would you like to know? The clinical trial consists of 15 intravenous infusions; I've had 11 so far. There are three arms: placebo, 50 mgs of the drug, and 100 mgs of the drug. (The study is double blind, but I'm sure I'm receiving the study drug, I just don't know which dose.) The infusions last an hour, and once they get the IV in, it's actually very pleasant.

Astra Zeneca supposedly has plans to start an open label extended study once this one is completed.

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Based on personal experience, I think so too. :-)

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@catpower, but how long realistically until doctors can treat us and help us? ??? i really do not know how much more i can suffer...my quality of life is unsustainable...

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@Daisy - how do you feel? has your depression lifted? if so, for how long? side effects?
why iv infusion? thanks

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@blueheelercd - My heart is with you. OK, something I have found very helpful recently is my therapist recommended I join a DBT group (dialectical behavioral therapy). It is a skills-based group where you learn how to handle difficult emotions, how to relax (through mindfulness meditation) and a number of other things - it is VERY powerful. It was originally developed for people with borderline-personality disorder in the 90's but is now being used for all kinds of problems - bipolar, severe depression, anxiety, you name it. There are groups all over the country now. Typically they are run (and should be) by a trained clinician. I never thought it would help me and when my therapist suggested it I was furious! Having tried other "process" groups like AA and NA, I wasn't sure how yet another group would help me - I didn't understand that DBT is skills based, so you are not just crying about your problems with no end in site. I hope I'm not overstepping in suggesting this, but maybe other people will find it helpful. I was so anxious when I started the group I didn't think I could drive the 10 miles to get there - or even get into my car! I share your frustration with the lack of good medications and the difficulty in getting into clinical trials. I have hope that maybe I'll be able to get into a AZD6765 trial and meanwhile I rely on my psychiatrist to help me find approved drugs that will help. I hope you have a psych. that you trust - that and a good therapist are what keep me going. If it weren't for them I probably wouldn't be here writing this. Hang in there and keep posting! We need each other; hope that isn't too corny but I believe it.

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Blueheelercd,

It's not a panacea, but I've definitely noticed an improvement in my symptoms, both in mood and functioning. The only real side effects for me seem to be sleepiness and an increase in appetite (I've heard that other patients have experienced a decrease in appetite).

I'm hoping that the sponsor unblinds the study once they've gathered all the data so I can find out what dose I'm on. It could be that I'm on the lower dose, and that the higher dose will prove to be more effective.

In any case, my depression has lifted enough that If there is an open label extended study, I definitely plan to enroll in that.

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Catpower,

Interesting! I'd never heard of DBT therapy before. I'm going to ask my doctor about it the next time I see her.

If anxiety is a problem, I should tell you that the most noticeable difference for me has been in my level of anxiety, which has gone way down since I started the infusions.

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@Catpower- I will look for the DBT, I never heard of it either.
AZD6765 - I did a lot od research, especially in other countries. It is almost the same as Ketamine, and lasts a vert short time. Shorter than Ketamine.
@Daisy too, what will happen when the studies are over? Will you still be able to get the medication? Or when it's over, it is over?

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All - below is hopefully a link to an article about J&J's phase 1 drug, esketamine! There is a (ph 1) trial going on in Belgium right now showing good response. Sounds like the whole NMDA receptor theory in depression/anxiety is Pharma's big new thing. Note, esketamine is an intranasal spray, not an IV drug. ****YAY****

seekingalpha.com/article/1542392-from-party-drug-to-antidepressant-johnson-johnson-vs-rivals?source=email_rt_article_readmore

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ALL, ACCORDING TO A 2012 SCHOLARLY ARTICLE, IT IS POSSIBLE THAT THERE ARE OTHER NMDA RECEPTOR MODULATORS, IN USE, AND FDA APPROVED, SAFE, BEING USED FOR OTHER HEALTH ISSUES RELATED TO THE SAME AREA OF THE BRAIN AND THE GLUTAMATE SYSTEM.
IT IS POSSIBLE THAT ONE OF THEM COULD ACCELERATE AND OR ENHANCE ANTIDEPRESSANT EFFECTS OF CURRENTLY AVAILABLE TRADITIONAL ANTIDEPRESSANT DRUGS.
THIS IS THE BEST NEWS YET, AS IT IS ALL SAfe and available now!
i.e. MEMANTINE AND AMANTADINE ARE BOTH NMDA RECEPTOR AGONISTS, WITH FLUOXETINE.
APPARENTLY AN NMDAR IS NOT THE WHOLE STORY, AS SHOWN BY THE TEMPORARY IMPROVEMENT WITH ALL OF THESE NOVEL MNDA RECEPTOR AGONISTS. THAT THE NEURO TRANSMITTERS AFFECTED BY ANTIDEPRESSANTS ARE STILL AN IMPORTANT PART OF THE PICTURE. NEITHER ALONE WORKS.
AS OF NOW THERE IS NO RX FOR TRD.
IF ANYONE WANTS TO READ ORIGINAL ARTICLE FROM PUBMED, LET ME KNOW AND I WILL SEND THE LINK. I AM GOING TO START ASKING MY DOCTORS FOR THESE MEDICATIONS, SINCE THEY ARE SAFE AND TRADITIONAL.
****HAVE ANY OF YOU LONG TIMERS NOTICED COGNITIVE IMPAIRMENT?
IT APPEARS THAT UNTREATED TRD CAUSES IT AS WELL AS EARLY DEMENTIA. THIS IS SCARRY, AS I HAVE NOTICED EVER INCREASING.
EARLIER HELP MAY BE COMING!

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Blueheelercd, yes, I've noticed a slight improvement in memory. What is a TRD, btw?

Had another treatment yesterday. Feeling pretty tired today, but I know it will wear off.

Catpower, I tried the ketamine nasal spray, and it made me feel really strange, so I discontinued. I would sure like to give the esketamine spray a try if/when it's approved, though.

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BlueheelerCD, can you post the link to the 2012 pubmed article? I don't think MedsChat has a problem with posts tho seems like sometimes they like to review stuff before posting. Thanks and thanks for all the info.

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