Glyx-13 Discussion
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There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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I read it may be available by 2016 but it didn't seem like a credible source.

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Is there any news on progress of GLYX13?

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That's great. I wish you continued success.

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I am holding steady. I have been in this"extension" safety study for over a year.

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Any updates to give us? Thanks

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Glad to hear you are seeing improvement. I believed I read somewhere that the pill form exerts a stronger antidepressant effect, hopefully, that is the case. How does it affect your energy levels and motivation? Have you seen improvement in that aspect?

Wish you continued improvement,
Darwin

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I am still in the GLYX-13 study. I'd say my mood is about a 6 with 10 being the best. That's a great improvement over the 3 or less I was at. But, I'd really love to remember what 8 feels like. The pill form is reportedly in safety studies now.

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Same here and I'm unable to think of anything else but the possibility that this will help me - after being on SSRIs since they came on the market I no longer feel any help from any of them and am beginning to get more and more down..

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Thank you for keeping us posted. I have really high hopes for this medication. Everything else I've tried has either pooped out or been sub par to no effect at all. Knowing this med is out there being tested gives me hope.

Best to you

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Still in the open label extension study and still doing fairly well. This is the first time any medications seems to be helping me. The oral version is in metabolizing studies for healthy individuals now. I will post information as I learn about it.

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I will ask on Wednesday when I get my infusion but I don't expect a clear answer;-) The "extension" study I am in in reportedly going to run for 4 years or until approval, if that says anything. I believe they are working on an oral version so perhaps more studies will open there as well. I have been getting 10mg/kilo IV I fusion weekly. I started feeling 10-15 percent better at about week 6, which is longer than the majority who feel better within hours. I don't know if the drug is helping but if I maintain even this much improvement through Feb/March, I will be grateful.

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Anyone know the most recent news on Glyx13 or any other drug currently in phase 2b or later in the same drug category ? I'm trying to get an idea if anyone knows, when a possible release date, or any idea of how much longer it could take until it's available from my Psychiatrist ? I've heard NAUREX has completed phase 2b and that there's talk of doing a phase 3 round. Any idea how many phases, even now that it's being "fast-tracked" until approval can be granted? Are we looking at months, or years? Any info is greatly appreciated!

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citygirl,

Good luck, and please keep us posted. I'm from New York originally, and I remember how tough winter can be in that part of the country.

I started taking a new a/d, Brintellix, in June. I've been tapering up very slowly, and I'm still not at a therapeutic dose, but it does seem to be helping. There are side effects, but for now they seem to be outweighed by the benefits of the drug.

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I have not felt a drastic change but am feeling a bit better than I was a few weeks ago. If I feel like this through the winter, THAT would be miracle enough. Winter is terribly bad for me. Here's hoping! I will take any improvement.

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citygirl,

How do you feel?

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The extension study stated last week. I just had my second treatment of 10 mg/kilo weekly. It goes for 4 years or until FDA approval. It is reportedly only for those who participated at least to week 12 in the previous study, but they did expand participation to those in that study to week 8 already. Perhaps it will/ or has open/ed more.

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TMS is a new option. Transcranial Magnetic Stimmulation. i AM RECIEVING It THROUGH kAISER. iT HAS BEEN APROVED FOR HARD TO TREAT DEPRESION AND SEEMS VERY EFFECTIVE. yOU HAVE TO GO EVERY DAY FOR 6 WEEKS.

I won't fix my awful cap reversal, too annoying...but you get the idea

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Trish,

Have you read the posts about GLYX-13?

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citygirl,

Please keep us posted!

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The "extension" study is finally starting for a limited number of those in the previous study.

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