Glyx-13 Discussion (Page 5)

There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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This probably doesn't bear repeating, but could anyone who hears when the glyx-13 phase III study launches post it here? I'll do the same if/when I hear.

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Read last month that the FDA just granted Naurex fast track approval for glyx-13, btw.

So that's good news...

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Great news! I hadn't heard that.

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Yeah. Makes me wish they'd hurry up and get the next trial underway!

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@Daisey.... This is madening. I am getting worried.

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This is incredible. This same group of people that bounce from the ketamine forum to the glyx-13 forum. We must all have the same genetic abnormality that presumably is a glutamate dysfunction. For what it's worth I'll share my cocktail if it's helpful to anyone else. I'm also anxiously awaiting glyx-13 availability. Everybody's dose is going to be a function of their own biology so I'll just post the agents. It would be very interesting to see how many of us are on similar therapies and try to pinpoint the ones most effective. It doesn't seem at this point that I can get along without anyone of them and together there is only a partial response but it keeps me alive. Thank G-d.

1. riluzole
2. venlefaxine
3. omega 3 Mood Formula (country life)
4. lorazepam (don't know how necessary it is for the depression but I do know there is an addiction at this point and I simply am not at the point where I can start to modulate this)

I really hope to G-d that all of those who are suffering will have their suffering eliminated. There are no words to describe the pain and dysfunction of this disease.

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Yeah, the waiting is maddening, but if they got fast track approval from the FDA, that's a good sign that it's going to happen eventually.

I have a feeling that we won't see the open label study starting before the summer, though. Who knows why these things take as long as they do; we just have to be patient (which is hard when you desperately want to feel better, I know).

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STLKET,

You're right, it's hard to explain, especially to anyone who's never been a sufferer.

If I had to describe it, I'd say it was like a rip current of fatigue and apathy that's constantly trying to pull me under.

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Naurex's website says the phase III trial of glyx-13 won't start until 2015.

Phase 2a trial of NRX-1074 is supposed to be starting now, though. No cities listed for that one yet, unfortunately. I'm trying to find out if there will be a study site in southern California.

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The open label I am hearing about, reportedly to start in June 2014, is referred to as an "estension." I hope that is different than the phase 3 starting in 2015! Thank you for the heads up!

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Any suggestion for a med for someone who has tried almost everything for depression and anxiety for over 25 years.going to my pdoc on wed, this is the worst I have ever been and I am scared. Please help. Thank you. Trish

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The "extension" study is finally starting for a limited number of those in the previous study.

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citygirl,

Please keep us posted!

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Trish,

Have you read the posts about GLYX-13?

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TMS is a new option. Transcranial Magnetic Stimmulation. i AM RECIEVING It THROUGH kAISER. iT HAS BEEN APROVED FOR HARD TO TREAT DEPRESION AND SEEMS VERY EFFECTIVE. yOU HAVE TO GO EVERY DAY FOR 6 WEEKS.

I won't fix my awful cap reversal, too annoying...but you get the idea

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The extension study stated last week. I just had my second treatment of 10 mg/kilo weekly. It goes for 4 years or until FDA approval. It is reportedly only for those who participated at least to week 12 in the previous study, but they did expand participation to those in that study to week 8 already. Perhaps it will/ or has open/ed more.

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citygirl,

How do you feel?

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I have not felt a drastic change but am feeling a bit better than I was a few weeks ago. If I feel like this through the winter, THAT would be miracle enough. Winter is terribly bad for me. Here's hoping! I will take any improvement.

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citygirl,

Good luck, and please keep us posted. I'm from New York originally, and I remember how tough winter can be in that part of the country.

I started taking a new a/d, Brintellix, in June. I've been tapering up very slowly, and I'm still not at a therapeutic dose, but it does seem to be helping. There are side effects, but for now they seem to be outweighed by the benefits of the drug.

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Anyone know the most recent news on Glyx13 or any other drug currently in phase 2b or later in the same drug category ? I'm trying to get an idea if anyone knows, when a possible release date, or any idea of how much longer it could take until it's available from my Psychiatrist ? I've heard NAUREX has completed phase 2b and that there's talk of doing a phase 3 round. Any idea how many phases, even now that it's being "fast-tracked" until approval can be granted? Are we looking at months, or years? Any info is greatly appreciated!

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