Glyx-13 Discussion (Page 4) (Top voted first)

There seems to be some demand for a GLYX-13 discussion (now known as Rapastinel) so I would like to start one here.

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Daisy, what where the side effects of the SSRIs that you weren't able to tolerate?
For me it was sexual dysfunction and akathisia (extreme anxiety with annoying sensations in my legs). I tried remeron as well, but it also gave me some akathisia. I have never been on any neuroleptic, but it seems that my body reacts to increased serotonin as some people react to neuroleptics. Did you experience anything of that sort while on SSRIs?

thanks

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I seem to be somewhat drug resistant. I am bipolar 2 and have altogether 18 years of therapy 11 of it full time. And over the last 9 years a range of ssri's. I am currently taking Wellbutrin, gabapentin, lamictol and sometimes amysulpride. This anti d, has had the best results so far ( which isnt saying much) I still plunge into unbearable depressions and feel stranded with nothing I can take to ease it-- so I am keen to know whenGLYX-13, is going to be available through a psychiatrist free ( as most are here in Italy) Does anyone have any idea about this? and how many mg's are to be taken in this 'single dose'?

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gillm,

Given that these drugs are still in phase II clinical trials, it's probably going to be a few years before they receive approval. But there might be a drug trial conducted in your part of Italy at some point. The website clinicaltrials.gov lists trials that are conducted both in the U.S. and other countries.

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Ketamine is very cheap! I obtained a vial of 100mg/10mg for $60. It's the infusion services where they get you. A lot of room for charlatans to abuse their medical priviliges to enrich themselves from desperate people. I tried IM injections of 50 mg ( the recommended dosage) but did not get the effects that the infusions provided. So I stopped. Now on Geodon + AD's which has helped to stabilize me for now. But don't feel as great as I did while in the Clinical Trials using Ketamine. It was me, but better! Someday...

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Paula,

You said that the ketamine you were given during the study worked, but it sounds like the same dose of ketamine given to you at the doctor's office didn't. Any theories as to why?

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I was accepted for the GLYX-13 trial in Chicago, but they told me I would have to wash out most of my AD meds and be without for 3 weeks and since I am having some success with my current regimen, I did not want to suffer that long with nothing just to get in the trial. When I did the Ketamine infusion study they did not require me to get off any meds, but I was on different meds at that time (about a year ago). I wanted to second the vote for therapy, I have been having some success with that as well because my issues are, I believe, brain-chemistry based as well as poor coping mechanisms developed to help me deal with early life trauma. In fact, trauma itself causes brain chemistry changes. My anxiety levels are way down and I am less reactive emotionally to episodes which would have sent me to bed for days before I started therapy. I look forward to the day when these currently experimental drugs are widely available, in the meantime I am going to continue with the therapy and the drug that really helped me which was Geodon added to my AD and other meds being taken for depression. I am still very interested in the GLYX-13 trials as well as any others being conducted to eradicate this scourge that has taken years from my life as well as all of you out there.

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hi guys. i'm 'john' from the original thread on ketamine. i think i was the first to post on that thread...

i am still alive. in deep depression though. so, it was a good surprise that a new thread was started off the original postings.

not sure why i am posting except to say that reading all your posts brought some hope. you can read my experience with ketamine in the other thread. i only had one infusion.

my question is; anybody here have a response after more than one infusion, when the first infusion did not work? dr feifel down in san diego told me that if a person does not respond to the first infusion, there is little chance of responding to multiple infusions. i am hoping since last year this may have changed since i was one of th first that he treated at his clinic.

i alos sent a email off to dr fiefel after reading all of this. have not heard back. i will report here what he tells me. he must now have a better idea i would hope about the ketamine infusions and protocol.

also, just to add; dr feifel uses no anesthesiologist when he does his infusions. just a nurse. he is very easy to work with compared to my ect doc at ucla who requires not only a lot more money, but much more paperwork, tests, etc.

i look forward to reading more. hoping we all can find some peace.

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Is the Glyx-13 study in Chicago at what used to be called Northwest Community? Addison and Central?

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Is there anyone here who has been in the glyx-13 studies? I have had two infusions to date. My previous posts seem to have disappeared (?)

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I had my third infusion on Monday. I have felt nothing, unfortunately. I am in the study in Chicago. I am glad to know you are having a response. Please keep us posted!

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@ John- I was in a Ketamine infusion study in Chicago suburbs 2 summers ago. Took me until after the 3rd infusion in the week before I responded and then it worked like MAGIC!! It was truly amazing. After that I was able to sustain the remission with one infusion per week. Then the study was over and I crashed. Doing better now with add-on Geodon and weekly therapy. Still wish I could feel like I did with the Ket. The world was my oyster. DON'T GIVE UP! Tell Dr. Feifel. 0.5 mg/kg dosing, M-W-F. The miracle! Serious. Good luck, get back and tell what Feifel says!

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Hi Everyone,

I was in the double blind AZD6765 study last spring and summer. I reported here that I noticed a big improvement in my depression. On December 31, I was notified that I had received PLACEBO.

I was totally stunned by the news, as I not only felt better during the study, but different than I ever had before. Has anyone else here had the same experience?

I was also told that the study sponsor, Astra Zeneca, has no plans to start an open label study at this time, no explanation as to why (I was previously told that they might conduct an open label study after the phase II trial ended). So that was disappointing, too.

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Hi JohnL

It's good news to hear that you had a complete remission during glyx-13 infusions. I would like to ask if you experienced any side effects during the period you were on it, and if there were any withdrawal symptoms besides headache. Also, are you sure you were on the drug and not on placebo?

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Good question, lol :-)

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My problem has always been severe hypersensitivity to the side effects of the antidepressants. I tried Fetzima a couple of weeks ago, and it hit me like a ton of bricks.

I'm about to try Brintellix, another new a/d, but I'm hesitant because I don't want to be disappointed again. Has anyone here tried it?

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Tomorrow will be my 10th "treatment" in the glyx-13 study in Chicago. I have not experienced improvement. I am told the open label study is a bit behind the original schedule but on track for an April start. I wonder why Astra Zeneca is not going forward with an open label study at this time?

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I just read (on Wikipideia) that Astra Zeneca has stoped development of AZD6567.

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citygirl,

I had no idea that it had been discontinued. Thanks for posting. I guess glyx-13 will be the one to watch from now on.

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citygirl,

Do you think you're on placebo?

Thanks for posting about the glyx-13 trial delay. I've been checking clinicaltrials.gov periodically because I'd like to try to get into the new trial when it begins.

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The first dose is either a low dose or therapeutic, as I understand it. I felt nothing. After the first dose, it is double blind. I concluded that I was either on placebo or that it does nothing for me some time ago. The lack of hope along with the winter months made the depression worse. I have little to lose by starting the open label study just in case I never had A therapeutic dose. Also, when I finish the study, the open label should just about start. I will post any info I get.

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