Is Anybody Being Prescribed Scopolamine For Depression (Page 3) (Top voted first)

is anyone being prescribed scopolamine off-label for depression? the NIMH is doing clinical trials for same and apparently it works, however my p-doc won't prescribe it for me.

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Yes, just started scopolamine as an adjunct to ongoing intranasal ketamine (life-long treatment-resistant major depression). I'm being treated by the MGH DCRP, absolutely amazing program. Feel free to post me any questions.

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Ketamine helps me. Unfortunately, I personally didn't respond well at all when we added oral scopolamine. However, I do know that it's being tested and found helpful by some others.

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So maybe don't remove it? I remember other patches causing similar marks and irritations. So what I'm saying is it could be more of an irritation of the dermis and not a reaction to medication. Could wait for skin oils or baths to wear down adhesives. Should not be a problem as meds in patch are already gone due to absorbtion. All I'm saying is you may not have to give up patches; certainly sounds like it would be worth looking into. Good luck!

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Hello, my name is Nick. Thanks for your post. I know this is over a year, and it'd be hard to believe you'd respond to my question, but, just in case, I'll ask. I have been through countless remedies, medication combinations, ketamine infusions, deep tms, stellate ganglion block, ECT, and much, much more with no results. Years have gone by where I am debilitated by this every moment of everyday in each sense of the word. I am just finishing my final (36th) session on deep tms and my 4th day with the scopolamine patch. I am constantly suffering, but I guess I am currently suffering a tiny bit less the past hour which gave me the ability to type this. Anyway, I was wondering how you were doing and how you did with the ketamine and/or scopolamine patch. Also, any other thoughts or advice would be greatly appreciated. I look forward to hearing from you.

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I would really like to know more. My number is 9xx-xxx-xxx9 and my e-mail is xxxxxx at yahoo.com [1]

[1] Editor's note - In order to protect privacy, we do not allow individuals to post their personal contact information on our discussion threads (except in some very rare cases).

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Do you have a link for this study?

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Here's a link to the NIH clinical trials.

clinicaltrials.gov/ct2/show/NCT00369915

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Let me tell you a few important things about using scopolamine for depression. First and most important, it should only be used BY PRESCRIPTION and under the supervision and care of a licensed medical doctor. Scopolamine interacts with MANY things including medicines, over the counter & prescription, supplements, vitamins, alcohol, etc.. It should never be taken while you are on anything else. It has worked for me but it does not work for everyone. It is best if you can do the clinical trial and then if it works for you, find a doctor to follow up with after the trial. I do believe it works for some people and highly recommmend you do the clinical trial at NIH.

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can get the patch online without rx via Canadian pharma.

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Yeah, good idea. Everyone can get to NIH and qualify for the study.

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how do you even get into a clinical trial? and do you have to be located there to participate? I can't tell from the NIH info page.

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Hi everyone. I know this thread is a bit old and it has been over a year since any replies have been made, but this thread has been about the only one I could find on the net that has actually participants in the use of scopolamine for depression, so I thought that I could post a question here.

A bit of background on me. I am going in for an evaluation with a doctor at UCLA for possible treatments using infusions of ketamine for a major depressive episode which has been plaguing me since my sister's death over three years ago.

A friend who has struggled with depression his whole life and I were discussing my possible treatment and he told me about these studies using scopolamine. After speaking to my own psychiatrist (who referred me to the doctor at UCLA) about the scopolamine studies, he told me that he would be willing to prescribe me scopolamine if the ketamine treatments were either ineffective or if for some reason I didn't meet the criteria for treatment.

The question I have is, besides subcutaneous injections, does anyone who is currently either taking the drug via patches or orally have any idea what the dosing regimens are? Is it done by a person weight or is there a recommended dosage for an average adult who is taking it as a possible treatment for depression? Is the dosage ramped up from a low one to a final dosage, i.e. is the drug titrated?

I'm glad to have a doctor who is open minded enough to possibly prescribe it, but since he was not familier with this use of scopolamine I am doing my own research to see if I can find an optimal dosing regimen and so far haven't been able to find anything on the net except the amount that was given intravenously to the patients in the initial studies and since an oral version or patch application of the drug would be considerably different (and much easier to obtain than trying to get injections), I want to see if there is some sort of protocol for it's use via the patch or in pill form for it's use in depression.

Thanks ahead of time for any help or possible answers.

Regards,

Michael

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My mistake. I was reading the thread backwards. It looks as if this thread is alive and kicking ;-)

Anyhow, any info you could provide would be appreciated.

Michael

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Helene - I'm assuming that you take it in pill form - have you (or anyone on this post) ever used the patch? If so, can you speak to the effects and results compared to the pill form? Thanks much - I looked into the trial but I am too old (57 - cut off is 55.)

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Love to communicate with you about this, however this site won't allow us to post contact info. I am desperate for a break in this 25 year battle with depression, anxiety and memory problems, i would so like to talk with folks about this. Thank you!

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Here are some links on studies:
ncbi.nlm.nih.gov/pubmed/20074703 (most recent--2010)

ncbi.nlm.nih.gov/pubmed/20736989

ncbi.nlm.nih.gov/pubmed/17015814


It's also mentioned on this link to a news story that aired in January on National Public Radio:
npr.org/blogs/health/2012/01/31/146096540/i-wanted-to-live-new-depression-drugs-offer-hope-for-toughest-cases

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Stevens pharmacy and compounding center in Costa Mesa, Ca does prepare compounded scopolamine capsules. The commercial drug Scopace is not being made anymore and was available as a 0.4mg tablet- call them at 800-352-3784

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I've had major depression for 20+ years, on/off various meds. Been on Pristiq 50mg for a while...it hasn't been helping. Talked to my Dr about Scop...she RXd me the patch to try. I did seem to help some, but irritated my skin and made me even more tired than normal. Got her to switch me to pills - Scopace 0.4mg (wondering why I was able to get it when others said they no longer make it). Anyways, I'm about ready to try it this eve.

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let us know! please!

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I ordered the transdermal patch from a Canadian pharmacy - expensive but no prescription needed. Am going to try tonight for the first time. Will let you all know what my experience is over the next few days. If it is positive, will talk to my doctor about getting a prescription. As with other comments, not sure of the dosing requirements for a therapeutic effect but figured a low dose patch is a good place to start.

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