Hydroxyzine Can It Work For Pain?
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I take gabapentin (Gralise) max dose daily for nerve pain. I get breakthrough pain at night. I have taken
A muscle relaxer and hydroxyzine and seems to help some with the nerve pain. Any clues about why as well as if hydroxyzine would work alone for the nerve pain?

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Hello. I also take Gabapentin for Nerve pain and I take Hydroxyzine HCL 25mg at bedtime for sleep issues and anxiety. I take the Gabapentin at 8pm and the Hydroxyzine at 11pm. I take one and a half Hydroxyzine. I have noticed that my Nerve pain is much better when I take an antihistamine plus the Gabapentin. I previously took Benadryl for sleep but had to stop taking it due to Serotonin Syndrome. The Benadryl seemed to help my Nerve pain as well. I was also taking the Gabapentin while taking the Benadryl. Maybe it helps with inflammation? Taking an allergy med along with the Gabapentin has definitely helped with my Nerve pain. I have Complex Regional Pain Syndrome Type 2 in my right foot and leg and it is a very painful condition.

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It has some sedative like effects, which is why it is often used for anxiety, so it can cause some relaxation/sedation. That might be why it helps.

The FDA lists its other typical side effects as possibly including dizziness, drowsiness, dry mouth, and headache.

Is there anything else I can help with?

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