Acebrophylline Versus Doxophylline

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advantage of acebrophylline

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1

Acebrophylline is an airway mucous regulator with anti-inflammatory properties.

I cannot find side effect information, but there is more information on the mechanism of action and chemical properties here:

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I hope this information helps, if there is anything else I can find for you, please post back and let me know

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2

what is the basic different in between acebrophylline and doxophylline.

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The therapeutic activity and safety of acebrophylline were evaluated in 50 patients (34 men and 16 women) with chronic obstructive pulmonary disease. The drug was administered for 10 consecutive days using three formulations—capsules, granulate, and syrup—at a dose of 100 mg twice daily. The effectiveness of acebrophylline was evaluated either on the basis of subjective symptoms and objective findings before, during, and after treatment, or on the basis of variables of pulmonary function as determined by using spirometry and blood gas analysis before and at the end of treatment. The results showed an early and positive effect of acebrophylline on the quantity and viscosity of expectoration and consequently a marked improvement in signs and symptoms of patients, with favorable changes in respiratory function. Safety and compliance with treatment were very good.

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4

Abstract

Doxophylline, or 2-(7'-theophyllinemethyl)1,3-dioxolane, is a theophylline derivative which has shown interesting bronchodilating activity, and it appears to determine few adverse effects. The aim of the present investigation was to evaluate clinical therapeutic effects of the drug in the treatment of 2 groups of patients suffering from moderate to severe chronic obstructive pulmonary disease differing in acute response to the inhaled beta 2-agonist salbutamol and to compare changes of lung function tests to serum concentration of doxophylline. We studied 67 patients with chronic obstructive pulmonary disease (median age 63 years, 9 females and 58 males) who were all clinically stable at the time of the study. Patients were separated into 2 groups on the basis of their reaction to inhalation of 200 micrograms of salbutamol: those with an increased FEV1 of more than 20% from baseline value (group 1), and those with no increase (group 2). Doxophylline was administered orally at the dose of 400 mg 3 times daily. Serum levels of doxophylline were determined by high-pressure liquid chromatography. Spirometry and blood gas analysis were performed before and 10 days after treatment. Four patients stopped drug assumption because of side effects (3 for dyspepsia and 1 for anxiety). In group 1 (34 patients), a significant increase in SVC, FVC, FEV1, FEF 25-75% and PEFR was observed. In group 1 (29 patients), only PEFR significantly increased. No modifications in blood gas analysis were observed. The mean serum level of doxophylline was 14 micrograms/ml in group 1 and 9 micrograms/ml in group 2: the difference was statistically significant. The relation between serum levels of doxophylline and FVC showed an increase in the parameter up to the concentration of 12-13 micrograms/ml, after which a plateau phase was observed. On the basis of our data, doxophylline appears to have an interesting bronchodilating effect in patients responsive to the inhaled beta 2-agonist salbutamol. The lower limit of the therapeutic range seems to be 12-13 micrograms/ml. The upper limit of the therapeutic range was not determined because it was not possible to obtain serum samples when side effects occurred.

PMID: 9088999 [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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5

can doxophylline and acebrophylline together can be taken



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6

Acebrophylline offers 3 in 1 action ie Bronchodilation, Mucoregulation & Anti-inflammatory action where as Doxopylline offers only Bronchodilation and anti-inflammatory effects. So theoretically Acebrophylline has an edge over Doxophylline in the management of asthma & COPD.

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7

i need curent information of accebrophylline and doxyphylline

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8

THE REPIRATORY SYSTEM AND THE DRUGS USE TO TREAT AND THETE MODE OF ACTION

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9

any data on efficacy of acebrophylline as a bronchodilator with the good bronchodilators?

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10

Is there any drawback of doxofylline over acebrophylline?

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11

Please let me know that I can use acebrophylline 200 and dexophylline 400 together For COPD.

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12

I've used Doxofylline but never used Acebrofylline. Can I use Acebrofylline for a prolonged period (i.e for more than 1 year) becoz of its lesser side effects?

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13

Doxiffiline 200 used with derriffiline
Dvr done
Now mcad finding

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14

May we take both, Acebrophiline &Dexophylline in same problem

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