Zydus 10mg Oxycodone Underdosed? (Top voted first)

Hello all. For the last 6 months, i've been prescribed various meds/treatments/pain meds for severe head pressure and neck pain. I had to stop taking any form of Hydrocodone because it makes my skin breakout in open sores (gross, i know). On May 6th, my PCP prescribed me Oxycodone 10mg 4times daily with great results and it made me very fuctional. He gave me another script for the same medication and when i went to the pharmacy, they filled it and when i got home, i notices the tablets/drug company was different. Well, was i in for a suprise. The new generics my pharmacy had were made by Zydus Pharmaceuticals and are imported from India? Well, to say the least, i've been taking almost twice my dosage to get the same effect. There's no way on earth that my tolerance doubled in less than a day! Now, my PCP thinks i'm trying to get more pills, and the pharmacy thinks i'm crazy. The first prescrption i got the 10mg oxycodone from this manufacturer: KVK Tech Inc (pink and "k 56" imprint on them. And they worked fabulous. These Zydus ones seem wayyyy underdosed as i'm taking around 5-6 tabs compared to 4 tabs of the KVK Tech brand. Any info/advice is greatly appreciated!

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Slightly lower is an understatement. I have been putting up with Zydus oxycodone B.S. for 4 months hoping things would change. They haven't and I can't take the bed rest any longer. I know other pharmacies carry KV or any other generic for that matter. Ill just put up with the looks and my doctors insistence that I go to one pharmacy, which I would be happy to do-if they carried a functional product. Come on you guys.. I'm too sick- but SOMEONE SHOULD CALL ZYDUS ON THIS. Test the pill. There is no way it contains 8-10mg of oxycodone( I'm giving them the 20% the FDA says they can short us). This has been 4 months of hell. My kids don't like watching me die and without relief from the pain their getting a front row seat. Thanks for nothing ZYDUS - hope that extra bit you saved by ripping us all of made your stock go up by 1/2 a point. You sure did earn a lot of customers who'll be turning their back on your medications.

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Hi, I am a RN and fractured my hip and developed hip bursitis -- I was taking waaaaay too many oxycodones for pain and my doc thought I had accodemated to them and I went on hydrocodone and was miserable for a month. I went back on my 10 mg of oxycodone and got no pain relief so I googled 'Zydus oxycodone' and was amazed at all the issues with their drugs, I called the pharmacy and of course they could not take my bottle of meds minus the 4 I took back but they did tell me to get my doc to write for the 5 mg tabs-2 q 4-6 hrs as needed, which he did. I turned the pills that did not work into him to be destroyed and filled out the FDA forms so they can check into the issue. Hope this helps

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I'm getting the same 10mg dose and am not getting the same relief I was getting from a different manufacturer and a lower dose. I'm sure it will be expensive, but I'm going to take one of my pill's to a company who test's drug's to see just how much oxycodone is in these so-called pain med's. I would'nt be surprised if they were just a placebo. when I get the result's, I will put a message up and if there not what they are suppose to be, I will contact every agency available to let them know that these are a scam.

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I absolutely agree with you--The KVK tablets are sooooo much netter--The zydus were like placebos--so I struggled for one month with them, and now I check my pharmacy before I fill my RX's to see what pharmaceuical company is prescribing them. It made such a difference. I just refilled my RX with KVK and I am so pleased with the difference after a month on the zydus--always do your research--Good luck!

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I have been on pain therapy for more than a year. The 10 mg. dosage was working fine, making me functional with my pain. They gave me the Zydus brand last time I filled my RX and they are useless. No pain relief. To make matters worse, they make me shaky, sweaty, irritable, and I'm in such pain I can hardly think straight. My left shoulder is in a knot. my right hip is constantly aches. I have to suffer a month like this. I have to do everything for Christmas: clean, shop, cook, entertain. I am dreading it. Just hope I make it.

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It is great that there is a website like this to help us. I have been taking 10 mg oxycodone for 3yrs. daily, last Fri 9-12-14 I picked up my prescription. When I got home I open the bottle and noticed that the pills looked different. I called my local CVS pharmcy to make sure it was correct they assured me they were correct and that it was a new pharmacol company named Zydus. So I took my dose, and I got no pain relief, I thought I would take 1/2 more I went to cut the pink round pill (mark NP/12) it crumbled into pieces, what is with that? I got some relief. ,but all day I felt sickly, sweaty and just not good. I take another around bed time, that night I was in pain all night and I woke up in a sever sweating mode, I was going thru withdrawal. I called the pharmacy first thing in the morning, they said the I had to wait till the manage got there Monday. I was sick all weekend, I talked to the pharmacy manager Monday and she can not help me at all. So now I have a month of this terrible under-dosed pain med, that is made in India from a company name Zydus. I looked on the internet to find that all the drugs that come from this company are Boges .I also have emailed CVS (LONGS) store customer relations and I will be calling them. I hope this post helps ALL.

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ALL OF YOU are absolutely right I brought this to my DR's attention he didn't seem to care or listen Ask 1st n do not accept them there are supposedly 80% more India pharmacies follow in there foot steps. Zydus even states on bottle manufactured in USA DON'T BELIEVE IT. QUESTION IS what can be done? litigation anybody? Any lawyers out there?

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You must work for Zydus to make a post like that. This is a forum of patients who swear Zydus brand oxycodone DOES NOT WORK. Zydus should be investigated and the authorities can use my Zydus pills to evaluate their authenticity. Bottom line again: DONT LET YOUR PHARMACY GIVE YOU THIS BRAND. The KVK works fine.

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Report them to the FDA using this form: fda.gov/downloads/AboutFDA/ReportsManualsForms/Forms/UCM349464.pdf. Mine came back with little to no drug BUT when lots of a drug are going through trials only 80% have to be perfect they have a 20 % that can be imperfect. Call your doctor and see if they will let you turn in the pills that are not working and prescribe you the 5 mg tablets or find a pharmacy that does not use Zydus. The key is to work with your doctor, thankfully mine was willing to work with me and take the time to destroy the pink pills and fill out the ensuing paperwork and the same with my pharmacy. I use a very small pharmacy so they were the only one with the bad lot so no recall issued. Good luck

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There can be fluctuations from one generic to another, so the one from Zydus may be slightly lower in the amount of the active ingredient and it just may not work for you as well as the ones from KVK Tech.

Learn more Oxycodone details here.

However, as you've discovered there are issues with convincing the pharmacy and your doctor of the problem.

Next time, you may want to use a different pharmacy, if your current one won't listen and order others in for you.

As to your doctor, I'm really not sure what you can do there, other than be completely honest with them. I wish I had some other idea for you, but I don't. Prescribing it 4 times a day is really the maximum he can do.

Does anyone else have any advice they can offer?

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Thank you Verwon! I'm just terrified about all this because the long holiday weekend is coming up and my PCP wis as hard to get ahold of than the President. These Zydus Oxy 10's are no way the same quality/dosage as the other brand, and i spoke with my PCP and pharmacist about this today and they said that this Rite Aid only has the Zydus brand available at this time. I tried today to convince my PCP to switch my current oxy 10's to a "brand name" and i'll spend the extra few dollars. Not a chance. He thinks my tolerance is growing, and thats complete BULLSH*T, as i've been fine on the other brand at the same dosage everyday for the past two weeks. Please everyone, tell me what i should do, as the anxiety is seriously overriding me about all this, and its making my pain even worse. Please help me, i am truly in need of what to do. Should i try a methadone clinic? Thats how disgusted i am with my PCP/Neurologist. They never return calls and when Friday comes around, i'm stuck, especially now since its Memorial Day weekend. This is absurd behavior on their part. Thanks for any help all of you can give me!

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Your 100% right. I have a bottle that I am bringing to a lab to be tested. Zydus asked I send them the pills. Yea ok sure, let me guess, they are fine. Had surgery and went well, no more need for pain meds, especially ones that do nothing

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So did anyone get these tested? I just filled a script today and have noticed no pain relief. Pharmacy cannot take them back and my Dr is out for the day. I'm considering going to the hospital. If anyone actually did go to the effort and expense of testing them , what happened? If these are not properly dosed or inactive cheap ingredients are interfering with absorption- they shouldn't be on the market and they WILL BE SUED!

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You are 100% right. When I was changed to different strengths of pain meds, I asked my pharmacy which brands they use b/c I noticed a difference in strength and they were nice enough to bring the bottles out to me, show me what they looked like and even said which ones were a bit better. You have to know your pharmacy and people that work there. There's a trust issue there that's very important. So I found the ones that worked the best after some trial and error and they put it in the computer to only order the ones I asked for. And just a side bar- You can do this with all medications. I get the same companies that I have asked for each month in all my medications.. Don't be afraid to ask.

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Jags, the best oxycodone to get in any strength is made by Actavis. Never Zydus their stuff is trash,. Always research your drug manufacturers and you can also ask your pharmacist before they fill it if they have Actavis most of them do.

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You are not Crazy. I have been taking 5 10mg pills a day for 13 months for sever neck problems. this past month my pharmacy had changed to the Zydus brand. I noticed it on the very first pill. We are not crazy. All generics are not created equal.

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I am grateful to see that there is conversation about this. The chain pharmacy that I have done regular business with has shown me that they regarded my concerns were not "real" and my responses was purely subjective. I used the Zydus brand of morphine er 60 mg for the next 2 months and I continued to have the same response. My pain was not being managed as well as when I received the Mallincrodt or Endo generic version. This concern was not regarded well by the pharmacy and I was told, in so many words, that I was welcome to go elsewhere as this was all that there distributor would send. Where I live, the 4 independent pharmacies that were in my area, have closed and have been replaced by the large chains. All of this said, in the last 6 months an independent has opened and the change in attitude has been HUGE. I had only to ask and the pharmacist got the version that worked the best for me and I have enjoyed patient centered care. The Zydus brand has issues and it is only through this type of Forum that consumers have a chance of being heard. Without healthy competition we can only be assured of mediocrity, or worse. Thanks to all. Be safe and resist intimidation.

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Yea, we're lucky that someone cares enough to help us with our pain issues. I'm tired of thinking about this too. Just want to keep living.

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For everyone having trouble vindication: statecolumn.com/2014/02/fda-bans-indian-firms-from-producing-drugs-for-the-u-s

FDA is pulling anything made in India, these 2 companies manufacture the components of the drugs

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Bottom line: Zydus brand oxycodone does not work! I have multiple failed orthopedic surgeries and was rx oxycodone 10mg 4x a day which has been very effective for years. The brand was KVK TECH. Recently my pharmacy was given Zydus by their supplier and then I was given this brand by my pharmacy. Immediately I noticed that I was having increased pain and very limited activity levels. I began having such horrible episodes of spasms and agonizing pain. I had to go to the ER and get IV pain meds and toradol. I called the pharmacist and he said he had other patients tell him that their oxycodone meds where fake. He looked into the issue further and discovered all the patients had the Zydus brand. I went back to my pain dr and the entire waiting room chimed on when they heard me discuss the Zydus issue with the nurse. Every patient on pain including the cancer patients were trying to find a pharmacy that did not dispense the Zydus brand. My pain dr now instructs his patients to speak with their pharmacist and only get the KVK brand. I will tell you almost all the pharmacies are being sold Zydus by their supplier and KVK is getting harder to find. Legal suit??

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