Zydus 10mg Oxycodone Underdosed?
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Hello all. For the last 6 months, i've been prescribed various meds/treatments/pain meds for severe head pressure and neck pain. I had to stop taking any form of Hydrocodone because it makes my skin breakout in open sores (gross, i know). On May 6th, my PCP prescribed me Oxycodone 10mg 4times daily with great results and it made me very fuctional. He gave me another script for the same medication and when i went to the pharmacy, they filled it and when i got home, i notices the tablets/drug company was different. Well, was i in for a suprise. The new generics my pharmacy had were made by Zydus Pharmaceuticals and are imported from India? Well, to say the least, i've been taking almost twice my dosage to get the same effect. There's no way on earth that my tolerance doubled in less than a day! Now, my PCP thinks i'm trying to get more pills, and the pharmacy thinks i'm crazy. The first prescrption i got the 10mg oxycodone from this manufacturer: KVK Tech Inc (pink and "k 56" imprint on them. And they worked fabulous. These Zydus ones seem wayyyy underdosed as i'm taking around 5-6 tabs compared to 4 tabs of the KVK Tech brand. Any info/advice is greatly appreciated!

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You are not crazy. Been taking plaquenil for years, Brand name, and generic. I had no problem until a week ago when they gave me Zydus generic plaquenil. From the first pill to today, it's like I'm not taking Medicine. The pharmacist thinks I'm crazy, and got smart with me. YOU ARE NOT ALONE!

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Re: Lyle (# 60)

I am curious what happened with this? I, too, am having major problems with Zydus not working for severe pain.

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Re: Rolls (# 11)

Please let me know the results. The new Camber mfr. is also useless! Check before filling. I am useless now and cannot do the essential things at this point! {edited for privacy}. Thanks in advance! Good luck too all of us!

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I TOTALLY agree! I was getting 7.5/325 totally fine. Then I got a brand ALVOGEN and they SUCKED... instead of 4 I had to take 8 to get the same amount of pain relief. So I went to my pharmacy, they told me they can only block that brand from being filled for me again... I was NOT happy with that. So I went to my Dr. He wrote me a new script for 10mg (no acetaminophen) I ended up getting ZYDUS. PHARM & THEY SUCK!!!! I KNOW my tolerance levels can POSSIBLY change, BUT I also know that I usually take 4-6 months before needing a slight increase in dosage. MAYBE if you return what you have left, MAKE SURE YOU HAVE PROOF, your Dr. will write a new script. Also, I found out that we can have our pharmacy BLOCK ALL GENERIC MEDICATIONS, which I will now be doing. Good luck!

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Re: littlek (# 2)

It's not in your head. They are not as good. I know for a fact! You must tell your pharmacy you don't want that brand anymore! People who are in great pain like myself know if they don't work as well and you are right, you have to take more than usual. Mornings, I have to double the dose just to make it! Horrible brand and at first I thought it was a placebo!

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Re: technerd (# 98)

I've had very good luck with them so far (knock on wood) lol. I'm wondering if it's batch based & some people are getting worse batches from different factories maybe? I couldn't figure out why so many people hated them & 8 saw many posts from this year.

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Well, just got my script filled and it's the Zydus brand with 12 on one side, pink & N P on the other. They seem fine vs. other brands I've tried. It appears they may have gotten better, as I see these posts are from 2014 & 2013. Can anyone else verify the brand is ok now just in case I got lucky?

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Not to go off Zydus, I was prescribed 20mg Oxycodone. I went to the pharmacy and looked at the bottle, saw the usual grey pills, same size, and looked like the KVK version, but when I got home I noticed there was no K on them. Never leave your pharmacy before asking what brand they are, because I took 5 with no relief at all. It was made by a company called Sun. Absolutely trash. I got stuck with 180 worthless pills. After investigating, I read a story on how the DEA raided a pill mill & confiscated 30 million dollars with the ingredients to manufacture drugs.

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Hello. Like the others above, I too believe that zydus oxycodones are completely worthless. I have contacted the FDA and they encourage people with concerns to fill out an online Medwatch form. I urge all of you to do this. There are people suffering needlessly because of this and I fear that people will overdose because of this as well....because if it takes 3 or 4 of the Zydus duds to feel any pain relief...and the said person takes 3 or 4 of another manufacturer---then they will overdose.

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Yes I was prescribed 4 10 mg of this product. It is supposed to relieve my pain (I had kidney transplant 6days ago) they only gave me relief for 1 to sometimes 2 hours. Only made the pain tolerable. Because I am on methadone 25mgs. Daily for nueropathy the doctors feel I might overdose. They r fools. I got some 7.25 norco and 3 every 4 hours does the trick. I think U.S. should stop doing business with India and other countries who manufactures medication. It is like Russian roulette for sure. Money is the name of the pharmaceutical game. And we who have chronic pains or major surgeries or past addictions suffer for this. Doctors in U.S. r being lied 2 behind money. I know this for every person who suffers because of incompetent doctors will not get the last laugh. God will see 2 this. Thank you.

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These are no longer made in India they are made under contract by Nesher Pharmaceuticals USA in Earth City, Missouri. A lab in the United States will always have strict quality control and is obviously FDA approved and tested. Given this new information and how strict US labs are, I'm sure that they contain the correct amount of oxycodone and they should be on the same level of effectiveness as any other brand. I can say they definitely work fine for me. I believe they previously were made overseas but that is no longer the case. Here is the link to the "Safety Data Sheet" that gives extensive information on this specific brand. It is where I got all this new information:

zydususa.com/wp-content/plugins/products/MSDS/Oxycodone.pdf

Also if you are every not satisfied with any new brand of drug that you pick up at the pharmacy the only way to replace it with a different one is to ask your doctor for a new prescription in exchange for the unused pills. Then find a different pharmacy that carries your preferred brand. The original pharmacy will never take medications back to give you new ones because they cannot sell them again because it is a safety risk (they could be fake, contaminated, tampered with etc...) Once they leave the pharmacy they can't accept them back.

PS. If your doctor does give you a new prescription, you may have to have him call the pharmacy/insurance company to let them know about the circumstances if you want to have any chance of having them covered by insurance. They already paid for the original prescription and it will probably require some kind of override. Also due to oxycodone being a highly controlled substance, the pharmacy will probably see the first prescription being picked up by you in the state database that they access to make sure people aren't seeing more than one doctor and trying to get more of this medication than they are supposed to. When they see that they will tell you that it's too early you just got it filled. The pharmacist will have to put in their own override. That is why it is extremely important that your doctor talks to both the pharmacist and the insurance company as i said above. Following the above steps will keep you from running into problems and wasting a lot of time. Hope this helps.

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That means that 4-10% of the pill is oxycodone and the rest is fillers. This percentage has nothing to do with the amount of miligrams (strength) of the pill. It means that the 10mg of oxycodone (the active ingredient) only makes up 4 to 10% of the mass of the pill, the rest of the pill is fillers and binders (inactive ingredient). If you dont believe me go to the website for the brand that you like more and look up their safety data sheet for their drug and you will see the same kind of information. It does not mean that you are only getting 4-10% of what they promised you haha. Hope this clears that up

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Please report to FDA? I'm going to and EVERYONE really needs to...I had the same thing. 1time on another med, Wellbutrin, I thought I was going nuts and to find out it was recalled from that co. For not being equivalent to name brand!!! We're not crazy but need to do something so report it! Thx

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Zydus is the worst medication that caused me extreme anguish. No pain relief in combination with fentanyl patch 25 mcg. With 10 mg and one half totaling 15mg oxy with fentanyl. First time with the Zydus I had terrible pain. Shoulder replacement on both. Either meds and replacement or just meds. At 64 years working as a carpenter, for 43 years my shoulder cuffs are destroyed. Zydus caused no relief. It is a criminal Hindu run company based out of Pennington, NJ. These people should be punished. I could not believe a company is worse than a ghetto dealer and is licensed to sell you fake watered down crap.

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You're NOT crazy!!!! I feel the same way, that's what lead me here! To see if there were any complaints!!! I guess the only thing to do is actually file a complaint with the FDA? And ask the pharmacy u go to how to do the same so they don't order? Oh and u can ask ur dr to request on ur script, whatever brand worked for u. Then ask ahead of time what pharmacy has that brand in stock!! They just buy from who ever's the cheapest!!! I used Mallinckrodt brand but now I'm not even sure about them!!! This is BULL CRAP, no one cares or monitors this crap!! I'm feeling really lousy on Zydus brand pharmaceutical, so never get those!!

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I am in the exact same boat. I'm sick of people calling chronic pain sufferers drug addicts. I too notice a DRASTIC DIFFERENCE between these same manufacturers. I thought I was building a tolerance, but when I took 2 different brands in the same day and the new bottle kicked back my pain far better & much longer (even though both are IR). People that say "there's no difference" may not take them as regularly if at all, or do not suffer from pain that literally NEVER goes away (or has good days & bad days). My pain is the same every day and never goes away. Only alleviated with pain meds. I notice a difference immediately. Zydus is absolute crap. Very inconsistent in texture even. Some are very hard while others are complete mush and they leave behind a dust film & stink. The kvk-t on the other hand may not be superior to say, Watson (which is what I started with years ago) but they are by far more consistent than the Zydus garbage. I keep complaining to my pharmacy but they ignore me, treat me like an addict and tell me I'm the only one to complain. I know that can't be true. For people that say generics are all the same, no way are they even close to the same. (Why did my mother have a MAJOR MEASURABLE DIFFERENCE in her blood pressure just couple days after her generic pills were switched? As if she had taken nothing at all?) While they are SUPPOSED to be the same, NO, they are NOT the same at all.

(BTW, I take the 20mg version. It's not limited to a particular dose, it's the company.)

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I must be totally backwards from everyone on this site. I'm prescribed 25mg of Oxycodone per day for back, hip & arthritis pain. Prior to that I was prescribed 20mg of Percocet per day. When I switched from the Percocet to the Oxycodone about 4 or so months ago, I filled my script at CVS & it was the KVK brand. That was the biggest crap I've ever taken & did nothing for my pain. I didn't feel like I had taken any meds. Taking two 10mg Percs did so much more than 25 mg of Oxycodone by KVK. I ended up switching Pharmacies after CVS said they only carry that one crap brand & the new one carried Zydus. I did my research & heard how bad it sucked but I filled my script anyways so I wouldn't go into withdrawal. I had zero hope that it would do anything based on user comments. Imagine my surprise when it not only completely took care of my pain, but messed me up so bad that I couldn't even function. I was like a drooling, extremely happy ***** for quite some time. I am able to take less of the Zydus brand & it has the same effect each time I get my script filled. I am baffled myself because other than myself I've never read a good review. My pills also are tiny, pink & have a 12 on one side & a NP on the other side. My pills are as hard as a rock & literally impossible to split in half with anything other than a pill cutter. Even a sharp knife has a hard time cutting through it & chewing it isn't the easiest endeavor. The NDC # is 68382-794-01. Are your guys' pills the same as described above?

I'm beyond confused about the different experience & the only thing I can think of is I'm a weirdo & metabolize meds differently than most people or I live in an area that gets the Zydus meds from a factory that's more heavy handed with the active ingredient & the rest of you don't? I do live in a totally out of the way state that probably 95% of you don't live in. I can't think of anything else.

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Yes I agree with you on the underdose of Zydus brand of oxycodone. I went thru my prescription sooner than expected and had a very hard time with withdrawal. Kvk tech shd be the only brand used

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Pink Zydus NP12
I couldn't agree more. This medication is crap

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I have been prescribed oxycodone for pain for 2 years after cancer and a car accident - both really messed me up. I have received all brands of the small pink ones and I can say for sure that the pink Zydus marked 12 NP are the weakest and worst quality. A simple method for evaluation is to chew one and you will see it gets gunky on your teeth instead of just powdery dissolve like all the others. The 12 NP Zydus are crap compared to all the rest.

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