Serotonin Syndrome With Medication Interactions

I'm on several medications like LYRICA 150 mg 3x daily. ZANAFLEX 4mg 2tabs at night. Amitriptyline 175mg suppose to be bedtime but i take maybe 6/7 because of the other meds at bedtime, Tramadol 50 mg 2tabs 4x daily. Adderral 5mg. Xanax 1mg 1tab as needed but the way the office wrote it was once a day. Topirmate 50mg 1tab 2x daily. Zyrtec 1tab daily, i also take supplements like magnesium oxide 400mg and vit D with calcium 600mg. Ive had B12 shots also which didn't work, i still have valium 5mg left over from my doctor switching it out with the xanax..,i almost forgot the water pill triamterene hctz 37.5 -25mg 1x daily and stomach med omeprazole 20mg 1x daily. Im diagnosed with chronic migraines. fibromyalgia. depression. anxiety. PTSD from guys in uniforms and something else that makes it difficult to leave my house. which Ive had 2 MRIs 2011-14 also been evaluated for lyme disease. Finally found a new neurologist i will see in june, now they're questioning partial seizures because i also have constant noise in my head a humming like a electric plant and i smell things that aren't there or hear things that no one else hears, i had go stop eating meat and cooking it it would make me physically sick, so now Im hearing all this talk about serotonin symptoms syndrome.. ive been on more than half these meds for over 10 yrs and they just started changing them around within the last year and my symptoms are worse than ever. So i guess im questioning if the meds im on are killing me slowly. i see my doctor every month because of the process of symptoms, i want to bring up serotonin syndrome. Is there a urine or blood evaluation that can prove it? how dangerous is it for real? anything you read says seek medical attention if you suspect it, but this has been going on for years. What can they do for me other than take me off all my meds and see where my baseline is? But i have kids that need me, im scared and confused. oh yes i almost forgot the memory confusion and memory loss....im not sure if this even makes sense because im doing this on a phone and having hard time typing. Thanks for any insight or comments you may have. oh i forgot my vision is changing for the worse; doubles; Blackspots. Everything goes blurry...

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#catsmeowri Hi, i posted a comment (kinda long),on the page the "most recent"list on here,and i cnt retype it all,but pleaz if you can,if thers anymore symptoms ur havin,wil u post them in a reply,if u n remember anymore. Im havin sum sever problems&they hav caused life changing issues. Please read my comment i ask. And then reply at ur convenience. Only bc my dr mentioned serotonon syndrome at my last visit,so im tryin now (actually for 2 days)),to findout wht i need to do. Il keep it posted asa i get a call in. Thank you&GODBLESS!

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Please read the drug interactions of Lyrica with any of the meds,thers websites tht wil let u type in lyrica then each of thes meds. But i do no your on several thst wil def cause serotonin syndrome,the tramodol,the zanaflex,all of the anti depressants.but i hope u caught it in time. I was only on lyrica&cymbalta,i was doin gud with my pain level til my drs partner upped my dosge on my lyrica then BAM! SEROTONIN OVERLOAD happened.i was ok with it til my dr then DECREASES MY CYMBALTA ovr a 2wk period then all hell broke loose.I went back to see my dr 2 wks aftr stoppin the cymbalta,which was 2days ago,he then said it was definitely SS. So now im in a constant anxiety rage inside my body,cnt see half the time due ti my eye lids draggin across my eyes. My whole body,bones,muscles,joints all hurt really bad,sum things hurt wher theyv nevrr hurt bfore.my finger joints are so stiff&swollen alone with my feet,omgosh it hurts to walk for awhil aftr i 1st gwt up.my bowels are loose,hav to pee literaly every 4r5 mins.it feels lik im pickin up 50pds with each arm r leg move. Breathimg is difficult. Sorry but i could go on byt im not sure youl even read byt mayb itl save sumone frm takin this med&ruining ther life.plus my fingrrs are numb. GODBLESS!

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@catsmeowri,

The previous poster has a good point about checking for drug interactions. So I took the liberty and did so via umm.edu's drug interaction checker. They list interactions between the following drug combinations:

Amitriptyline + Tramadol: taking the two together may increase your risk of certain side effects, and may cause problems with your blood pressure, body temperature, muscles, and thinking. It may also result in tramadol not working as well for you. They recommend contacting your doctor if you have a seizure, confusion or mental changes, a fast heartbeat, blood pressure changes, high body temperature or sweating, drowsiness, lightheadedness, fainting spells, difficult or slow breathing, or if you feel that tramadol is not working for you.

Amitriptyline + Topiramate: taking the two together may increase blood levels of amitriptyline, causing them to be too high; which may increase your risk of amitriptyline-related side effects. They recommend contacting your doctor if your experience drowsiness, dizziness, dry mouth, constipation, difficulty urinating, or a headache.

Amitriptyline + Valium (Diazepam): taking the two together may result in decreased coordination and ability to concentrate. It may also increase your risk of certain side effects. They recommend contacting your doctor if you experience changes in mental awareness, loss of balance, slurred speech, or slowed reaction times.

Alprazolam + Omeprazole: taking the two together may increase blood levels of alprazolam, which may cause more side effects than usual. They recommend contacting your doctor if you experience changes in mental awareness, loss of balance, or slurred speech.

Omeprazole + Valium (Diazepam): taking the two together may increase the effects of valium as well as increase your risk for certain side effects, such as drowsiness, dizziness, lack of coordination, and confusion.

Ref: umm.edu/health/medical/drug-interaction-tool

Bottom line - If the side effects have become too bothersome or severe, you should probably do what's best for your mind & body and work with your doctor to determine if the benefits outweigh the cons.

I hope this info helps!

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We're drug twins almost! Lol. I have ptsd from marrying a pedi. Them same child from church leader. Then another child from a neighbor, childhood friends dad. Then another neighbor crush on older ...tbc...low battery

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Hello, I'm replying to you about your vision problems, humming, noises, ptsd, all the other things you've listed... I suggest you see someone really good for a complete brain scan.. They need to analyze you extremely cautiously, incase you have a tumor growing... This sounds and feels like something growing in some spot of your brain to cause every symptom you've listed so far.... If you've already done this, I suggest you do it again. Look for something that's almost like a pinched nerve....something growing. I'd check that out immediately. Especially for your kids. I'm so sorry you are becoming confused and scared... I imagine and feel you..everything will be ok, just keep faith. Let me know how it goes. Much love. Jeannette.

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I almost got serotonin syndrome from Amitryptaline. My stomach hurt SO MUCH because my intestines were pumping out serotonin more than my body could handle. It has such a long half life it took days to go away after I stopped taking it.
Serotonin syndrome can kill you.

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