Off-label Use For Treatment Resitant Depression

Clinical trials were looking at the use of opiod agonists as off label anti-depressants. Since they block the release of glutimate without the more addictive opiate side effects. Also, releases more dopamine? Ketamine also being studied as well as anti-inflammatory drugs in combination with opioid agonists? I am probably mistating the complex bio-chemistry involved, but bottom line it seems like anti-depressant meds are all moving toward reducing inflammation by reducing glutamate release, (or is it the other way around) from the spinal column by binding opioid agonists to the pain receptors. Thereby also increasing dopamine release. I know several experimental drugs were in the pipeline but some fizzled out. Any ideas as to truly "new" anti-depressants for treatment resistant major depressive disorder? Bupronorphine hydrochloride was also mentioned frequently.

REPLY

REPORT

1 Reply

RE: "Any ideas as to truly "new" anti-depressants for treatment-resistant major depressive disorder?"

In my opinion, the idea of something being "treatment-resistant" is clinically biased for each individual's unique case of depression (or whatever condition it is that ails them). That said, to each their own and what works well for some people may not work for others. I think if we were able to come up with a long list of things we've all tried for depression, perhaps others can use it as a template for working with their doctor or in some cases self-medicate (responsibly) with alternative non-pharmaceutical options.

I do believe that opioids, when administered responsibly, can help alleviate depression - especially if it stems from pain or other related bodily discomforts. However, in today's opioid climate, this is but a dream and I feel that Kratom is a wonderful alternative.

REPLY

Was this helpful? 0

March 15 looking for a center greater Los Angeles area or throughout the country that is not acute facility but similar ...

1 REPLY

Nuvigil (armodafinil) saved my life. I've had treatment resistant major depression for over 20 years. Tried so many ...

31 REPLIES

If someone is being treated with fluvoxamine and are then diagnosed with graves disease could the fluvoxamine also be tr...

2 REPLIES

Has anyone any experience taking this medication and has it helped for your Depression? I realize this is not yet consid...

42 REPLIES

looking for a center in Southern California that takes Medicare for treatment of bipolar and depression ## Hello, John! ...

2 REPLIES

For 40+ years I have battled bipolar illness.. been through all meds, many ect, rTMS. and clearly dealing with trd... Ho...

4 REPLIES

Has any one been prescribed savella for depression only? I would like to know how it has worked for you and if you find ...

4 REPLIES

this drug has recently been prescribed to aid in my adolesence growth. he is below the average height for a 12 year old ...

4 REPLIES

Is it okay if I use Althea Pills eventhough im 17 years old and im a boy, just to treat my pimples? is there a side effe...

6 REPLIES

I have been given this medicine 100 Mg tablet three times a day for hydrocele. How it works for hydrocele? I will be ope...

33 REPLIES