Hydroxyzine Pam 50mg/ Bupropion Sr

Is it safe to take bupropion SR and hydroxizine pamoate at the same time for anxiety and depression?

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Hello, Sherry! How are you?

I didn't find any problems or interactions listed between these two medications, but it's always best to double check such information to be safe.

As listed by the FDA, Bupropion may cause side effects, such as nausea, dizziness, dry mouth and drowsiness.

Hydroxyzine may cause side effects including dizziness, drowsiness, sedation and dry mouth.

Is there anything else I can help with?

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I read somewhere in a pharmacology textbook that using both can possibly increase your risk of seizure with bupropion. Though your dose for bupropion needs to be 200mg or more and you would need to take your hydroxyzine at the same time for the seizure risk to be heightened so space the two medicines out about an hour from eachother just to be safe. No increased risk of seizure should occur from just taking your Wellbutrin normally.

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