Details Of Synasma 400 Mg (Top voted first)

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I am a patient with hypertension for ther past 50 years. I am 80 yrs old (female). - live alone. I hsve a good family doctor. Am on Amlong H, concor cor 2.5 mg; ecosprin 150mg, and Atorsave 10 mg.
I have been having shortage of breath for the past 6 years. It has increased now and my doctor has told me to take Synasma 400 mg half tablet twice a day for 10 days. I am curious to know what this drug is for. Thank you. Janaki Menon

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1

ANY SIDE EFFECTS FOR SYNASMA 400Mg

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2

ANY SIDE EFFECTS FOR SYNASMA 400Mg AND IS IT A PERMANENT CURE FOR WHEEZING AND WHAT ARE ITS SIDE EFFECTS?

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5

it is potent bronchodilator with lesser side efeect. it act on bronchial smoothe muscles

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6

I am 22 years old and since 8 months when I take deep breath, I feel some irritation and start sneezing.
Doctor has prescribed synasma 400 mg tablet (once a day), telekast-L and Lupituss oral suspension.
I just want to confirm whether these medicines are appropriate for my illness as I am neither allergic to anything nor sufferinf from shortage of breath. Please help me with this if anyone can.

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7

i have bronchial asthma and i undergo respiratory problems,for which i use tubutalin and seroflo.whether synasma would serve the purpose and what are the side effects which are serious and damaging.further whether theophyllin is better.

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8

I am 40 yrs old. For past 5 months I am having cough which disappears with medicines on and reoccurs in few days. It starts dry coughing and followed by a thick cough yellowish cough. I keep coughing whole day.
Now a days my doc has advised me Zyrcold twice a day , .... Once a day and Budesal nabulisation twice a day.
I have relief but feel that I should cough slightly. I don't know how to explain. All my blood reports and chest XRay are ok.

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9

Latest news for medicine update

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10

Can I use synasma 400mg for getting relief from wheezing

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3

Here's the link. I guess you might find it informative.

"Doxofylline has a prolonged bronchodilator effects and unlike theophylline it has least adenosine interactions i.e., no CNS and CVS side effects. There is no sleep disturbances and no effects on gastric secretions with doxofylline. It is highly safe in smokers."

http://www.drugsupdate.com/generic/view/870

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4

Synasma is reported to contain the active ingredient Doxofylline, and is manufactured by Ranbaxy. It is used in the treatment of asthma, and supposedly has few side effects.

"In animal and human studies, it has shown similar efficacy to theophylline but with significantly less side effects.

Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects." [1]

"Doxophylline, or 2-(7'-theophyllinemethyl)1,3-dioxolane, is a theophylline derivative which has shown interesting bronchodilating activity, and it appears to determine few adverse effects. The aim of the present investigation was to evaluate clinical therapeutic effects of the drug in the treatment of 2 groups of patients suffering from moderate to severe chronic obstructive pulmonary disease differing in acute response to the inhaled beta 2-agonist salbutamol and to compare changes of lung function tests to serum concentration of doxophylline. We studied 67 patients with chronic obstructive pulmonary disease (median age 63 years, 9 females and 58 males) who were all clinically stable at the time of the study. Patients were separated into 2 groups on the basis of their reaction to inhalation of 200 micrograms of salbutamol: those with an increased FEV1 of more than 20% from baseline value (group 1), and those with no increase (group 2). Doxophylline was administered orally at the dose of 400 mg 3 times daily. Serum levels of doxophylline were determined by high-pressure liquid chromatography. Spirometry and blood gas analysis were performed before and 10 days after treatment. Four patients stopped drug assumption because of side effects (3 for dyspepsia and 1 for anxiety). In group 1 (34 patients), a significant increase in SVC, FVC, FEV1, FEF 25-75% and PEFR was observed. In group 1 (29 patients), only PEFR significantly increased. No modifications in blood gas analysis were observed. The mean serum level of doxophylline was 14 micrograms/ml in group 1 and 9 micrograms/ml in group 2: the difference was statistically significant. The relation between serum levels of doxophylline and FVC showed an increase in the parameter up to the concentration of 12-13 micrograms/ml, after which a plateau phase was observed. On the basis of our data, doxophylline appears to have an interesting bronchodilating effect in patients responsive to the inhaled beta 2-agonist salbutamol. The lower limit of the therapeutic range seems to be 12-13 micrograms/ml. The upper limit of the therapeutic range was not determined because it was not possible to obtain serum samples when side effects occurred." [2]

Hope this helps!

[1] https:/­/­rxchat.com/­wiki/­Doxofylline/­

[2] http:/­/­www.ncbi.nlm.nih.gov/­pubmed/­9088999

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