Apotex Vs Pliva Trazodone (Page 5)
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My pharmacy just switched manufacturers of my prescription trazodone 50mg. It used to be made by apotex now it is pliva and I am finding that the new pills are having little to no effect and I am starting to suffer discontinuation syndrome. I talked to my pharmacist and doctor and neither one could tell me what was causing this. I was just wondering if there is anyone out there who could shed some light on the subject.

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23

Thanks, I see that the apotex shortage is due to the fda ban just recently being removed so maybe they will be able to catch up. I also found that Mylan works fairly well (anything is 100 times better than plavia) but I see there is a shortage there too. Again, many thanks to you all.

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22

I have called everywhere and no one carries it anymore. I think it's been yanked from distribution for some reason. Traz by Mylan is the only alternative I've found that works for me. Good luck.

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21

ashp.org/DrugShortages/Current/Bulletin.aspx?id=681
Hope this works. (Appotex release has been delayed)

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20

Has anyone been successful in getting a script filled for Apotex Trazodone? If so what pharmacy? I tried with my Rite Aid and their supplier said they couldn't get it or know if they would be able to. I was hoping against hope that this waiting game was going to end, but I guess not. Thanks for all the advise and help.

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19

Good news everyone! I just went to the Apotex website and they are going to start shipping again to the US. They issued a press release about it on May 11. Just go to their website and you can see it.

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18

Have been taking Pliva generic trazodone for 3 months. I can't swallow the pills, so I chew them (yuk) BUT some of them are very bitter and some of the taste like chalk. I'm not sleeping alot of nights - hmmm, the chalk nights. Anyone know how to report this to FDA?

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17

Mine is Teva USA. Is that one any good? I haven't started it yet. I got off Remeron because of itching and am supposed to start Trazadone. Any info on Teva?

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16

Very useful info. I have been taking trazodone 75-150mg. qhs for many years. Recently got 150mg. Pliva at CVS. It is a HUGE trapezoidal-shape pill (sharp angles) which I've had trouble swallowing. I'm curious as to why some generics are much larger than others (and the brand in most cases). 'Fillers' seems to be the logical answer.
I got a flat oval tab (trazodone) from WalMart not long ago and will try that. CVS said they cannot get other generics. I am a bit catious because there has been a merger/ acquisition between Pliva, Barr, and TEVA ( not sure of when) and have no idea how that will play in.
Thanks all for your reports of side effects of this generic. I have been experiencing some mood fluctuations recently (more than my usual) and didn't even think of the traz change until I searched about the size/shape issue.
I say NO to most generics of maintenance meds. My endocrinologist INSISTS on Synthroid--no levothroid or other substitutions. I have noticed a huge diff btwn Klonopin and generic clonazepam which I take qhs for bruxism (potentially cause by SSRIs).


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15

Costco just refilled my Apo (tex) T50 with Pliva last week and I couldn't fall asleep for 4 hours every night. Had severe withdrawal syndrome so had Primary Phys call in a scrip to Walmart for Mylan 50mg. after calling MANY pharmacies in town. No APO anywhere here in san diego, only Pliva and Teva. Slept thru the night with the Mylan the last two nights. No grogginess and feeling alert thru the day. Thank God!

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14

My pharmacy just switched to Pliva and I started the Trazodone 3 nights ago. Can't go to sleep without taking 50% more than I'm used to AND getting severe headaches in the middle of the night. Anyone else experienced these headaches with the Pliva?

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13

I have been in touch with Apotex since last spring and they keep telling me to check back in three months regarding whether or not it will come back on the US market. I guess there's a possibility it won't. They told me to check back again in February.

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12

I am having the same problem with the trazodone made by Pliva, which my Pharmacy switch to because they could not get Apotex. This is the second time this has happen, previously it was about a year ago but they were able to resume filling the Rx with Apotex in about two months. They were able to get Mylan but it still does not work like Apotex. Really having a hard time with this, its like I am having withdrawals (anxiety, irritability and disassociation). Does anyone have any suggestions or know if Apotex is still making trazodone?

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11

I was taking Trazodone 50mg by Mylan. Recently switched from Walmart to Walgreens. Walgreens uses Pliva. I did not expect any differences, but after only a few pills I can't sleep well and i feel a bit more anxious - this started right away. It didn't dawn on me that it could be the pills. Also, i am experiencing side effects again that I experienced when I first started taking the Mylan pill. I should be over side effects for Trazodone, so maybe the side effects are from the inactive ingrediants? I don't know. I got a new prescription & will be switching back to the Mylan as soon as I can get to the pharmacy today.

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10

As a psychiatrist, I have found trazodone to be an extremely useful medication. I'm not sure what the product made by Pliva is, but I've seen many, many patients do poorly on it; it seems to act more like an antihistamine--i.e., it does make people drowsy--but it does not seem to restore a high-quality sleep. The best trazodone, in my opinion, is sold by Qualitest; Apotex is okay, but in our opinion not as good. We always specify to the pharmacy, Trazodone NOT made by Pliva.
Here's my question: once a generic company is certified to make a generic product, do they ever have to be recertified? Or can that company just coast along for decades, turning out God-knows-what, and everyone assumes it must be okay because the FDA, once upon a time, checked it out and declared it okay?

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9

I am not able to take Pliva but can take Apotex. Here is the problem right now. All dry pills from Apotex are on hold by the FDA for about 2 months. That means the main ones available are Pliva which is owned by Barr who is now owned by Teva. I was able to find some 300mg Apotex which I am cutting up to get what I need.

Call around. Walmart had Mylan. There is also Qualitest and some others.

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8

One other thing...I have been experiencing hair loss since I started taking the Pliva brand...don't think it's a coincidence. I was fine with the Apotex. Anyone else experience this?

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7

I just called Apotex and the customer service rep told me that they are having some problems with the FDA but once they are resolved, trazodone will be back on the market. She estimated it would be a few months.

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6

I have been using Trazodone 50 mg APO for many years with great success. Pharmacy just switched me to Pliva and it is a disaster. Was sleeping 8 hours a night now waking up at 4:00 AM Can anyone help??

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5

Interesting...I just got pliva after taking apotex for a couple of years. I am finding that I'm sleeping better with the pliva but it doesn't control my hot flashes like the apotex.

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4

Happened to me to --- went from sleeping 7-8 hours most nights to sleeping 5 hours. Taking an extra 50mg didn't help at all. It's very frustrating.

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