Zydus 10mg Oxycodone Underdosed? (Page 5)
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Hello all. For the last 6 months, i've been prescribed various meds/treatments/pain meds for severe head pressure and neck pain. I had to stop taking any form of Hydrocodone because it makes my skin breakout in open sores (gross, i know). On May 6th, my PCP prescribed me Oxycodone 10mg 4times daily with great results and it made me very fuctional. He gave me another script for the same medication and when i went to the pharmacy, they filled it and when i got home, i notices the tablets/drug company was different. Well, was i in for a suprise. The new generics my pharmacy had were made by Zydus Pharmaceuticals and are imported from India? Well, to say the least, i've been taking almost twice my dosage to get the same effect. There's no way on earth that my tolerance doubled in less than a day! Now, my PCP thinks i'm trying to get more pills, and the pharmacy thinks i'm crazy. The first prescrption i got the 10mg oxycodone from this manufacturer: KVK Tech Inc (pink and "k 56" imprint on them. And they worked fabulous. These Zydus ones seem wayyyy underdosed as i'm taking around 5-6 tabs compared to 4 tabs of the KVK Tech brand. Any info/advice is greatly appreciated!

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REPORT

If you really want to know why these pills suck follow me to the yellow brick road, opp's I meant the makers own website!!!

zydususa.com/product-details/?id=127&Strength=10mg

Go to the right side of the page and click on the MSDS link, then scroll down to number three and read -

3. COMPOSITION/INFORMATION ON INGREDIENTS:

Component
CAS No.
Amount
Oxycodone Hydrochloride
124-90-3
4-10%
Amorphous Silicon Dioxide
7631-86-9
1-5%

Note: The exact percentage is withheld as a trade secret

So my 10mg Oxycodone really has between 4 to 10 percent of oxycodone in each pill. So if it were on the high side (say 10 percent) then my 10mg oxycodone pill has 1 mg of oxycodone in it! This is right from the makers website. Nesher Pharmaceuticals (USA) LLC A Zydus Company. 13910 St Charles Rock Road. Earth City, MO. 63044

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It's not really the pharmacy's fault, it's the insurance companies and the government regulators that are screwing us. I just got another batch of Zydus oxycodone's and like last month these also suck! I take 40mg's of Oxymorphone that works great 90 percent of the time and I used to take an oxy 15 now and then for breakthrough pain and they worked great.Now my pharmacy gave me the Zydus 10.s and last month I had a really bad day and ended up eating 12 of the Zydus 10's within a hour and then googled the pill after 2 hours wondering if I was accidentally given childrens Tylenol or something. 120mgs of oxycodone and didn't even feel it? Something is not right here. I ask the Pharmacist about the same thing with the Adderall and he told me he never knows what brands he is going to get from month to month so for instance if he gets three bottles of say 1000 adderall's one brand may cost him 300.00 for a thousand another brand 400.00 for a thousand and the last bottle of really good but still generic may cost 900.00. Now pay attention because this is why we get crappy meds! He charges you your co-pay, say 5 bucks for 60 pills then sends Medicare-Cade Obamacaid a bill for the rest + a small profit but The Carekaides will only pay him 300.00 a bottle so he has to wheel and deal and hope he doesn't loose his ass so he can supply you with anything. This is why the Rite aids' and Wal-Marts' stopped carrying most meds they don't make a bunch of money on. At least I got a good batch of Adderall this month or I wouldn't be posting this :)

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As with most regularly prescribed opiate medications, the initial "2 weeks in" window is prime time territory marking a general point at which the human body begins to require an increase in dosage in order to achieve consistent effects. Both physical and cognitive reliance can stealthily creep up and settle in with regular opiate consumption. Euphoric trigger regions of our brains become active in direct causal response to opiate medication. These are the same neural regions as those activated during positive life events of any form which naturally produce feelings and sensations of happiness/satisfaction/optimism. This is the universal core commonality behind any and all displeasure one may experience or endure in conjunction to opiate reliance.

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I would love I see their clinical trials. FDA needs to stop this med from entering the US! I have been in Oxycodone for 6 months due to my back being mangled...I took one pill and noticed how much I started itching... Thought maybe something else, dry skin... Whatever.. Took my next dose... Noticed red welts ! Never again. Gotta see Dr tomorrow to see what she can do about exchanging these meds. I looked at all the crap they put in their meds... Unbelievable!

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ALL OF YOU are absolutely right I brought this to my DR's attention he didn't seem to care or listen Ask 1st n do not accept them there are supposedly 80% more India pharmacies follow in there foot steps. Zydus even states on bottle manufactured in USA DON'T BELIEVE IT. QUESTION IS what can be done? litigation anybody? Any lawyers out there?

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I take 4 10mg a day. I just filled my script today (12/03/2014). Took this little NP12 pill an no relief. As I'm doing more research it seems ALOT of people are having this problem.

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I too have had the same exact problems hoping to get my pmdr to read some if these n rewrite me a new script I was supposed to have 20 mg but pharmacy was more than happy to double RX with zydus 10 mg gee do u think they know save mart RX

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It is great that there is a website like this to help us. I have been taking 10 mg oxycodone for 3yrs. daily, last Fri 9-12-14 I picked up my prescription. When I got home I open the bottle and noticed that the pills looked different. I called my local CVS pharmcy to make sure it was correct they assured me they were correct and that it was a new pharmacol company named Zydus. So I took my dose, and I got no pain relief, I thought I would take 1/2 more I went to cut the pink round pill (mark NP/12) it crumbled into pieces, what is with that? I got some relief. ,but all day I felt sickly, sweaty and just not good. I take another around bed time, that night I was in pain all night and I woke up in a sever sweating mode, I was going thru withdrawal. I called the pharmacy first thing in the morning, they said the I had to wait till the manage got there Monday. I was sick all weekend, I talked to the pharmacy manager Monday and she can not help me at all. So now I have a month of this terrible under-dosed pain med, that is made in India from a company name Zydus. I looked on the internet to find that all the drugs that come from this company are Boges .I also have emailed CVS (LONGS) store customer relations and I will be calling them. I hope this post helps ALL.

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Tell your pharmacy you have to have the better brand of oxy. I do that and my doc agrees. Tell your doc you want to switch back and to write the brand on your script. My doc does that and i looked around for a pharmacy that would fill that for me with the brand i like. You don't have to have the doc write the company name on the script but it helps. The pharmacy can special order for you that brand if they are willing.

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I just posted on a similar topic.. I knew I should have copy and saved it- as always- but forgot this time. You are right. I have had to do tis in the past with meds that were changed out (the MFR) between Rx refills)... the 10 mg ZYD Oxycodone is s*** (excuse me- but I am pissed off) 1/2 as strong as even the KVK everyone is complaining about. These 10mg ZYD pink, 12 on one side & an NP on the other should be OTC- I paid good money for these and they are junk. I have not developed a tolerance either- in the time frame I am speaking in regards to.. they simply do not work. No one at the FDA is watching over the Rx coming int this country- I know they are short handed and busy but this is ridiculous- it started with Clonozipam- mfr's changes as did the quality and working effects during the day.. I did go back to my Doc & gave back the Rx and he gave me another Rx and I promptly went to another Pharmacy- I have an excellent honest trusting relationship with my doc- never lied to him.. imagine that.. so when I tell him something he's no reason to disbelieve me.
A**hole Pharmacies. all in the name of saving US money- change manufacturer all the time- they don't realize the effects it has on patients when they do this- it is NOT just about the strength but the fillers are all different. Some do not even dissolve (ask any septic tank pumping guy.. he'll tell ya how many pills he gets that are NOT dissolved- and you cannot tell me they were dumped that morning before pumping! And it's BS to help us, the consumer, save $$$... it's about making them more money. Deep pockets, you get name brand meds- otherwise settle for the s***.

As far as Methadone- you were wondering about. It works well for weaning yourself off H. Clinics will allow you to request up or down in dose- though I hear it has become very expensive these days for even minimal regular maintenance- I would be careful.. the effects can range from hot flashes to aches and pains you never knew you had.. The reason? It is NOT the same methadone that clinics dose you with- the 20 mg orange-ish disckets. Not even close... the white aspirin looking 10 mg Methadone works but again, you may or may not develop a s***ty reaction... you could try them and see- for H weening- great! DO NOT take candy bars with Methadone! DO NOT... you know what I am speaking of... Xanax- don't do it. Liquid Hand-Cuffs- VERY tough to break.. But, if your goal is to stop the up and down roller coaster high, detox or take more, detox or take more- EVERY day- methadone might work for you. Two 60 mg time release MS Contins/day may be a good alternative for you.

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For everyone having trouble vindication: statecolumn.com/2014/02/fda-bans-indian-firms-from-producing-drugs-for-the-u-s

FDA is pulling anything made in India, these 2 companies manufacture the components of the drugs

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Report them to the FDA using this form: fda.gov/downloads/AboutFDA/ReportsManualsForms/Forms/UCM349464.pdf. Mine came back with little to no drug BUT when lots of a drug are going through trials only 80% have to be perfect they have a 20 % that can be imperfect. Call your doctor and see if they will let you turn in the pills that are not working and prescribe you the 5 mg tablets or find a pharmacy that does not use Zydus. The key is to work with your doctor, thankfully mine was willing to work with me and take the time to destroy the pink pills and fill out the ensuing paperwork and the same with my pharmacy. I use a very small pharmacy so they were the only one with the bad lot so no recall issued. Good luck

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So did anyone get these tested? I just filled a script today and have noticed no pain relief. Pharmacy cannot take them back and my Dr is out for the day. I'm considering going to the hospital. If anyone actually did go to the effort and expense of testing them , what happened? If these are not properly dosed or inactive cheap ingredients are interfering with absorption- they shouldn't be on the market and they WILL BE SUED!

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I'm getting the same 10mg dose and am not getting the same relief I was getting from a different manufacturer and a lower dose. I'm sure it will be expensive, but I'm going to take one of my pill's to a company who test's drug's to see just how much oxycodone is in these so-called pain med's. I would'nt be surprised if they were just a placebo. when I get the result's, I will put a message up and if there not what they are suppose to be, I will contact every agency available to let them know that these are a scam.

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I have been on pain therapy for more than a year. The 10 mg. dosage was working fine, making me functional with my pain. They gave me the Zydus brand last time I filled my RX and they are useless. No pain relief. To make matters worse, they make me shaky, sweaty, irritable, and I'm in such pain I can hardly think straight. My left shoulder is in a knot. my right hip is constantly aches. I have to suffer a month like this. I have to do everything for Christmas: clean, shop, cook, entertain. I am dreading it. Just hope I make it.

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Your 100% right. I have a bottle that I am bringing to a lab to be tested. Zydus asked I send them the pills. Yea ok sure, let me guess, they are fine. Had surgery and went well, no more need for pain meds, especially ones that do nothing

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Its nice to know i'm not the only one with this issue! Y'all wont believe what i had to do to get another script: i attempted suicide. It was a bulls*** attempt but it literall had to take those measures to get the doctor's frigging attention! Now, i'm in pain management, and i'm getting the 7.5mg oxycodones (4 tabs daily, sometimes need more), But i ALWAYS make sure to see what brand it is from now on. Either Qualitest, Mylan. If they dont have that brand, i go elsewhere. I'm not gonna EVER be forced to go thru what i went thru just because of some greedy pharmaceutical company's f*** up. I was told "there are better ways to get things done" Oh really? The doctors wouldnt even call me back, let alone continue my treament. So, i had to, theoretically speaking, set off an alarm. Because before that, nobody was bothering to help me. Now, they know not to screw around and not take my word for it. Sucks i had to do that, but hey, i got what i needed!

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Yea, we're lucky that someone cares enough to help us with our pain issues. I'm tired of thinking about this too. Just want to keep living.

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I have been feeling much better (stomach wise) taking the zydus rather than taking other copycat brands.
Hmmm.... thank you for your message because I finally got through thinking about this.

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Slightly lower is an understatement. I have been putting up with Zydus oxycodone B.S. for 4 months hoping things would change. They haven't and I can't take the bed rest any longer. I know other pharmacies carry KV or any other generic for that matter. Ill just put up with the looks and my doctors insistence that I go to one pharmacy, which I would be happy to do-if they carried a functional product. Come on you guys.. I'm too sick- but SOMEONE SHOULD CALL ZYDUS ON THIS. Test the pill. There is no way it contains 8-10mg of oxycodone( I'm giving them the 20% the FDA says they can short us). This has been 4 months of hell. My kids don't like watching me die and without relief from the pain their getting a front row seat. Thanks for nothing ZYDUS - hope that extra bit you saved by ripping us all of made your stock go up by 1/2 a point. You sure did earn a lot of customers who'll be turning their back on your medications.

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