When Referring To Santly Collagenase Ointment What Is Meant By " And Help To Facilitate The Spread Of Gas Gangrene"?

When referring to Santly Collagenase ointment what is meant by " and help to facilitate the spread of gas gangrene" ?

"Collagenases are enzymes that break the peptide bonds in collagen.

They assist in destroying extracellular structures in pathogenesis of bacteria such as Clostridium. They are an exotoxin (a virulence factor) and help to facilitate the spread of gas gangrene.
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Hi Robert,

Based on my research, I believe that "to facilitate the spread of gas gangrene" means that this product is intended to treat a Gas gangrene infection. The ointment must stop the spread of the infection and kill the bacteria.

Gas gangrene is rare in the United States. The condition is most often caused by a bacteria called Clostridium perfringens. However, it also can be caused by Group A streptococcus. Staphylococcus aureus and Vibrio vulnificus can cause similar infections.

Clostridium is found most everywhere. As the bacteria grow inside the body, it makes gas and harmful substances (toxins) that can damage body tissues, cells, and blood vessels.

Gas gangrene develops suddenly. It usually occurs at the site of trauma or a recent surgical wound. About 1 in 5 cases occur without an irritating event. Patients most at risk for this usually have underlying blood vessel disease (atherosclerosis or hardening of the arteries), diabetes, or colon cancer.

Information referenced from:

nlm.nih.gov/medlineplus/ency/article/000620.htm

I hope this helps, do you have any more questions?

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Santyl is the correct spelling.

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