To Answer Questions About Linzess (Top voted first)

I been on Linzess for like 2-3yrs. It is the best that has happened since Zelnorm.
I seen everyone's Q&A's and tp answer those in question. I work 8-4pm and usually take it around 3pm giving it an hr or so before eating and by 6 or 7pm it works wonders. For those having severe constipation like myself, I take another before bedtime which is 11/1130pm and by 530am it also releases the rest of stool. So in short, take one around 11pm or bedtime AND another the next day around 3pm (ASK your doctor first if two is suitable- as im not sure and never asked) AND (depending on your work schedule). Just make sure it's an hour before you leave work.

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I believe if you take it twice a day you may desensitize. I cannot site the NIH page I read this on but you could Google it. Best to probably stick to the prescribed method of taking. This drug does require tweaking as to the amount; my first two weeks were miserable but now it works great...as long as you are near the bathroom as you would not want to miss the window of opportunity or the loo.
Good luck to all.

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To begin, I have chronic constipation syndrome. Linzess was such a blessing for me until it became ineffective after about 1 1/2 years. Is that what you mean by being desensitized ? So I switched to Amitiza it it has worked fine for about 1 year until it became problematic. Now I have resumed taking Linzess and it is working like it first did when I originally began taking it.

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