Taking Phenergan And Zofran Together (Top voted first)

Hello. I have been prescribed Phenergan via IV PICC line for nausea in combination with Zofran IV as well. Do these meds work well together? I do seem to be having side effects of blurred vision, itching and some abnormal feeling in my legs that makes me feel as if I must move or get up and walk. Is this a side effect or just something else going on?

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According to the University of Maryland Medical Center (umm.edu / drug interaction tool), there is a dangerously high interaction potential between the active ingredients in Phenergan (promethazine) and Zofran (ondansetron); which states that taking the two together may cause serious problems with your heart.

Further details suggest that if these two medications are necessary, your doctor may adjust the dosage, timing and/or frequency of administration in order to lessen such risk factors.

They go on to note that you should contact your doctor immediately if you experience: Chest pain or discomfort, shortness of breath, unusual heartbeats, dizziness or lightheaded, feeling like you're going to pass out, or feeling very weak.

I hope this information helps!

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Re: David (# 1)

Thank you very much for the info. I will pay close attention to my body if any of those symptoms happen! So far, it's just the blurred vision, itching....but the moments are becoming greater in frequency and intensity. I take Benadryl to help with the itching, but sometimes comes a few hours later and it's mainly my face that itches. I also take oxycodone now. This itching is so intense! Any advice?

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Naw, you exactly right. When I take too many promethazine in a days time without any other opioid, I start to get that restless leg syndrome to where I can't keep my legs from moving. I hate that feeling cause it's so uncomfortable when that happens.

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