Hi Ren, have you finished taking the course of Efudex at this point? Medline Plus says "If you are using fluorouracil to treat actinic or solar keratoses, you should continue using it until the lesions start to peel off. This usually takes about 2 to 4 weeks. However, the lesions may not be completely healed until 1 or 2 months after you stop using fluorouracil." It also says that the redness is normal, except in cases of a severe red skin rash (which should be reported as a serious side effect). Would you consider your case severe?

As to treating the redness, you may be able to apply an over the counter cream or ointment, but you may want to get that cleared by your doc first just to rule out possible issues post-treatment. I tried an online drug interactions checker for the ingredient Fluorouracil and nothing came up, but that probably doesn't include OTC products. Plus in your specific case, you'd likely need to be selective as to what product(s) could help. If you do speak with your doctor can you please let me know what they say?