Prolia Issues And Side Effects (Top voted first)

I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered horrible side effects such as terrible constipation, leg and foot cramps, skin rashes, stomach pain,etc.

I also found out that Prolia works by stopping the body's own bone production, causing old bone to become denser. This results in probable fractures due to old brittle bones, Prolia also causes low calcium levels in the blood, a weird side effect seeing it is supposed?to strengthen boned!

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Judy,

I am also s high risk fracture patient, but increasing bone mass with old bone does not decrease your fracture risk.

Prolia just increases bone mass by stopping the body's own bone remodeling process, It can also decrease blood calcium levels, which is a strange side effect for a supposed bone strengthening drug!

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Have had 2 inj's., heart fluttering, Weakness, fatigue, lightheaded, to the point of feeling like I was going to pass out, that was first inj., ended up in hospital, many diagnostics but nothing showed up. Did not relate it to Prolia inj. as it had been a few months since inj.. Had second inj. three weeks ago, side effects are severe, heart flutters, confusion, weakness, severe fatigue, almost to the extent of not being able to function, throat tightness hoarse voice, extreme heartburn and indigestion.... The list goes on and on. Wondering how long this will last, sometimes I feel like giving up, I am 73 years old

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Has anyone had memory problems after taking Prolia?

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I do not think the FDA is interested in suffering patients in Australia!

I do take Vitamin D and try and eat a well balanced diet, however aI have had 8 back surgeries in the last 25 years and now have chronic pain syndrome.

The side effects from the Prolia just add to the overall misery.

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I'm not sure the FDA cares. I have never hurt so bad in my life -- my spine feels worse than when it breaks and I have constant headaches, cannot use right arm and after injection was barfing and diarrhea. I wish there were a way they could take our blood and put in clean blood without Prolia and it may help us start feeling better to get this stuff out of our bodies. There will NEVER be another injection in my life. It knocks out our immune system so a simple spider bite won't heal which is usually a 5 second job.

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Don't do it!!! I have an earlier posting which you may be able to reference, but after 3 shots I was nearly debilitated to the point my family (not my prescribing) doctor had me tested for Parkinson's, MS, Alzheimers, and other neuro-muscular possibilities. I virtually became another person both physically and emotionally. After 6 months since my last injection I am beginning to return except for the nearly constant aching in my legs. As a former rower, skier, and teacher of stage movement I have always been able to walk great distances. Now, I'm lucky to be able to do 3 miles at a very slow pace and with considerable effort.

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I read a report not long ago on the study of osteoporosis drugs and showed they had no results in building bone. It made fractures worse and slower healing. Will never take another drug for osteoporosis. Walking and other weight bearing exercises will help and calcium and vitamin d at the proper levels.

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My 3rd injection was 8/13/14 in October I started getting mouth pain went to the dentist new dentures in the 8 months I have suffered everyday and night I have been to oral surgeons, ent. I now have tmj. I am 44 and this injection has ruined the quality of my life. I have another appt in June at the Cleveland clinic. I will never recommend this injection. The FDA has no idea of long term side affects.

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Poodle: I am sorry to hear of your pain. Side effects vary for each individual. My initial contact with the FDA consisted of a list of my side effects.

Consider having a look at the National Osteoporosis Foundation web site.

FDA Online Med Watch: 1-800 332-0178
Amgen Health: 1-877-562-4111

You can request a free report of Prolia events from the FDA at:

Office of Management
Division of Freedom of Information (HFI-35)
5600 Fisher Lane Room 1035
Rockville, MD 20857

Call: 301-796-3900
Fax: 301-827-9267

I hope your doctor was able to give you some help.

Wishing you the best

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I am sorry to hear what you have been through. I agree with you that Prolia could have contributed to what happened. What I have been reading about Prolia has convinced me to pass on that remedy.

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Sorry you are dealing with the results of something that is supposed to be helpful. And you can bet the FDA knows more than what they share. Good luck to you.

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It has been 6 mos. and 2 weeks since my last shot of Prolia. I did NOT take the dose due this month. I am STILL experiencing muscle weakness and spasms, including the muscles of my face and head. I am miserable ! It has been my mission to spread the word about the negative effects of this drug.

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Re: Mason (# 62)

My understanding of this communication stream is that it is used to report possible side effects of Prolia and provide communal support for those experiencing them. Why are you here?

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Vitamin D and Magnesium are also important for bone health and density. Have either of your doctors recommended supplementing with any nutrients to use alongside the Prolia? I'm not a doctor myself, but perhaps overtime you may not have to rely on Prolia as much if you're taking other preventative measures as well through diet and exercise.

It's unfortunate that many types of prescriptions can backfire with side effects that are almost opposite of what it's intended to treat. Hopefully you're not experiencing any more negative reactions to the Prolia... but if you do you can always report serious side effects to the FDA via their MedWatch Program at: fda.gov/Safety/MedWatch/default.htm

I hope this helps!

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Anni, I had my last Prolia shot Feb. 23, 2015. The side effects have been horrible. I am still suffering from a lot of the side effects, including all of what you described. I will not take another shot!!

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Your story reads like mine. I did not get my second shot... Too many side effects. I'm too sick now.. And sorry I had the first shot. Now my goal is to wait, treat side effects and rebuild my health.... Thank you for sharing...

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I had two Prolia injections. Loosing hair to the point where I am going to buy a wig. Anyone else having this thinning hair issue after using Prolia?

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Yes- my hair loss is ridiculous- I need a wig to hide my male pattern baldness. I look more like my dad now... and I am his daughter!

My constipation is followed by days of loose stool- bloating - gas- and then randomly repeat that cycle.

Brain fog is so frustrating- I also have insomnia and everything noted here triggers my anxiety---

Also weakened muscles which include large muscles, small muscles, weak eyes- weak bladder muscle- I am 18 months post prolia shot-

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I wanted to respond to your comment about how Prolia works. My physician, who was also my oncologist and familiar with Prolia as a drug given to bone cancer patients, explained that it actually works by extracting the calcium out of our blood and depositing it back into our bones to counteract the bone loss created by osteoporosis. This process is why those on Prolia need to supplement our diet with extra calcium. I take 1000mg of bariatric calcium a day. Having said this, I will not take a second inj. due to the side effects. While they were milder than most I've read about, I have experienced constipation which is compounded by the calcium supplements, mild depression, thinning hair, and I also believe a "foggier" mind.

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Re: Mason (# 62)

I suppose you are aware that sudden hair loss may be a sign of illness in its own right. I am not referring to male pattern baldness, which may be the cause of thinning hair in men.

You may also be aware that the majority of contributors to this and related threads have been diagnosed with osteoporosis and subsequently are suffering from side-effects of Prolia. The many and varied side-effects reported by contributors include those that are extremely serious and totally debilitating, life-altering, depressing, disfiguring, or just incredibly hard to live with. Hair loss is an issue for many.

My own experience with Prolia is mainly autoimmune issues: a variety of skin issues, massive lethargy and lots more. Then the has been the inability to work coupled with massive expenses for investigations and failed treatments. I have got off very lightly compared to most people.

The poster here mentioned factually that she is suffering hair loss. Most of us do. But how do you think it feels to lose your hair when you are already sick and miserable? Pretty darned depressing, that's what, especially if the anti-itch shampoo is stripping the color out and your skin looks like you are probably contagious with bubonic plague.

That's not my idea of vanity.

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