Prolia Side Effects Duration (Top voted first)

Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happen?

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The side effects of bone, muscle and floating body pain were severe for 2 months and continued with less pain for over 4 months. The itching and rash continued for over a month and was treated with prednisone. The dizziness and lack of balance lasted for over two months. The nausea lasted over a month. The overall side effects continued for 6 months. My immune system was weakened and the results of this continued for the last 10 months. I came down with Epstein Barr virus, have had strept three times and pick up whatever goes around easily. My cholesterol is still very high. My reactions lasted over 11 months. My health is very poor, and I continue to struggle to regain it.

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My mom was extremely sick after getting her second injection of Prolia. She could not lift her hands up to get dressed in the morning. She could not zip up her pants after using the bathroom. All her joints and muscles ached. She had severe jaw pain and had trouble eating and sleeping. She was completely disabled for one year. We even filed a complaint with the FDA telling them to take this drug off the market. My mother's oncologist from the Mayo Clinic suggested that she take acupuncture. My mom received 10 acupuncture sessions and has been cured of her joint/muscle pain. The acupuncture therapist made it a point to work on her muscles and joints. She has regained her strength and energy and is back to feeling well again. She refused to get a third injection of Prolia. This drug has some very nasty side effects and should be taken off the market. Do your research and look for other alternatives but don't get a Prolia injection. For those suffering, we recommend you take acupuncture and maybe you will be healed like my mother was. Blessings to all of you!

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First injection Feb. One week later could barely walk or use my arms due to pain. Now have back pain, musculoskeletal pain, cholesterol very high and walk with a cane or walker,very seldom drive now, due to arm weakness.AND my doctor said there were no side effects.!!! Will not take second shot in August.

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One of my biggest worries is the jaw/gum problems. I have two friends, one in Cslifornia and another one in Florida that have lost thir teeth and both needed implants and dentures. This threat along with the horrible pain and discomfort produces in me panic. I am 69 and I have decided to be exposed to the minimum of medicines possible.

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Had my Prolia shot in early Feb 2014 now Mar 25 after a scan showed extreme bone loss. I have been experiencing major pain issues. Within a week I had stabbing pain in right shoulder blade, left leg and foot swollen and reallly red and for the past week I have had jaw pain on the left top which radiates up to my eye and down my neck into my shoulder. The injection site was in my left upper arm. I also have Lyme Disease so it is hard to tell which symptoms belong to which problem at this point. I just know that since the injection I have been in extreme pain and popping T3 with codeine without much relief. Is there any way to flush the Prolia through my system quickly and get back to just trying not to fall down?

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The FDA wrote me that in the test subjects of Prolia, side effects started to go away in as little as 10 days and lessens as time goes on so that at 2-1/2 months we should be symptom free. That does not seem true from what I'm reading here. I wonder, how much money AMGEN paid them to release this poison.

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Had 3rd injection of prolia. Have severe lower back pain,nausea,arm and leg pain.hands hurt . Have tried to be active. In constant pain. Called dr. on pain meds. Will not take anymore injections of prolia.

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I have been on Prolia for two years and recently I have been suffering from shortness of breath and tightness in my chest. Has anyone else been suffering of any respiratory symptoms....

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Short answer: NO! Prolia can stay in a human body in trace amounts forever. There is no end to a half life. It goes on to infinity. There is nothing known that will delete Prolia from the human body. FACT: Straight from AMGEN.

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Oh my Goodness. What have they done to me. Still at 11 months and immune system is not back yet??? I personally believe Prolia to be worse than death itself because it sure makes us feel like we are or wannabe. I'm in tears reading your post.

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FDA writes half life of Prolia is 26 days. It continues to linger in the human body for 11 months. I don't know if they followed up after 11 months or just quit keeping track of subjects. I am now in the care of a Cardiologist. Thanks Prolia!!

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Have you rec'd any info on your question. Or since May can you tell me if you still have the pain? When or if you have reprieve yet... My 3rd Prolia Injection 8 days ago after 3rd day WOW. . The pain is unbelievable.

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I have suffered from hives, light flashing in my eyes and ovarian cancer. Prolia should be taken off the market. I am under going chemo right now. I know Prolia is responsible because all of this happened after the shot.

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Of course Prolia causes cancer because it weakens your immune system which fight the cancer cells. We have cancer cells in us all the time. It is the job of our immune system to kill them. When Prolia diminishes this response, yes, you can get cancer very, very easily. I don't want it again!! Once in a lifetime of that is certainly more than sufficient. Hopefully, you will find an excellent oncologist.

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First (and only) injection 6 months ago...ongoing side effects, but perhaps beginning to lessen the last week or so. Time will tell.

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Re: Bunny (# 108)

Congratulations to you for doing what I usually did until I made the mistake of following my Dr.'s advice without researching this horrible drug.

I had my first and only Prolia shot on the 30th of March, 2017. Four days later I was at the Emergency Dept. of a local hospital here (Im in Canada). I had an autoimmune response that included severe erythema lesions on my legs, feet and elbows. The pain was unbearable and I could not walk. My husband had to take me to the hospital in a wheelchair. Nobody at the hospital (and I saw three different MD´s) wanted to write the word "Prolia" in my file. The three of them told me that it could have been "anything"... I asked them to write it at least as a hypothesis... (a month later, however, when I requested a copy of my file, the reference to this poison was nowhere written). Three weeks after the inj., I had lost 20 pounds and was loosing my hair, my heart was racing all day and I was suffering from extreme fatigue. At that point I went to see my GP who had prescribed this poison and told him what I thought. He told me he had “many, many patients on Prolia and nobody had had any side effects”. What I found quite curious is that the Dr. had kept a list with the names of all the patients he had prescribed Prolia to. He showed it to me emphasizing that I was the only one who had had these reactions. I told him that I thought I was “lucky enough” to have had these reactions immediately after the first shot while many might have had several shots before they had a severe reaction. Perhaps many out there who have had reactions do not associate them to this poison because these reactions did not happen immediately after the first shot.

I had breast cancer 6 years before Prolia and I realize that my Dr. should have never given me this inj. (now that I understand how these monoclonal antibodies type of drugs work in your immune system). When I had cancer I did not want to have chemo. I chose to do immunotherapy. The goal was to increase my T-killer cell count and strengthen my immune system. I won that battle and after my 5th year post-cancer, I was not only cancer-free but healthier than ever. My skin, my hair, my mood, and my whole health had never been better. I went back to my gym 5 days a week, had a perfect weight and when I turned 60 early this year, nobody could believe my age. I then had the bad idea of having my yearly check-up and listening to my GP when he suggested that I underwent a densitometry to later insist that I should use Prolia. I must have been in the 10 most stupid minutes of my life when I accepted this poison without having done my own research! It was so totally different to what I did when I was diagnosed with cancer! When I understood how Prolia works, I cried for days, realizing that I had been given a drug that is used as chemotherapy and that also causes your T-cell count to go down and go totally crazy. In addition, In order to get rid of the erythema on my body, I had to be treated with Prednisone, a corticosteroid that leaves you immune-depressed… I was living a total nightmare. Despite the nightmare, in the middle of July I was feeling slightly better and had partially recovered my weight. I travelled to South America and shortly before my trip I felt that the whole cycle was beginning again. But I had my ticket and still felt well enough to travel.

Shortly after my arrival there, I was having palpitations, was feeling extremely tired and my hands were shaky… I had to urgently see a Dr. who immediately diagnosed me with hyperthyroidism. I was put on two medications and only started to feel better and regain my weight about two or three weeks later. In the month of September, when the thyroid medication had already been reduced and I was feeling quite well again, we were celebrating my daughter`s B-day when everyone noticed my eyes were swollen. I have seen at least three Ophthalmologists since. None of them seemed to care about my story. I have been told that having swollen eyelids happens with age (LOL), that I need artificial tear drops because my eyes are too dry, etc…. Fortunately I have been in touch with the Endocrinologist I saw in South America. He believes that I have Graves Ophtalmopathy, probably as part of the whole autoimmune response to Prolia and that unfortunately, this tends to run parallel to the thyroid disorder. In other words, it may not automatically correct itself even if the thyroid is well controlled. He believes it is imperative that I am treated with Corticosteroids to prevent the eyes from popping out… which has not yet happened as only my eye lids are now severely swollen but the eye globes seem to still be contained... I`m desperately trying to find a reasonable Dr. who would put me on Prednisone or another immune-suppressor, as I realize I have no other option. It is not only a horrible condition aesthetically speaking, but is also causing vision problems as I have diplopia and photophobia….

Please, if anyone in this group has had the ophthalmic problem associated with the thyroiditis following the use of Prolia, could you please share the name of the medication that has been given to you for this and the actual prescribed dosage?

October 30th was the 6th month anniversary since my life was transformed by this horrible “medication”. I look like 10 years older than 6 months ago. What used to be my beautiful hair, is falling out, as I have only seen in cancer patients who are undergoing chemo.

I agree fully with those of you who have said this drug works in cycles…. That is what I have experienced. I currently am again experiencing fatigue, insomnia, and strange ‘migratory’ pain in the bones, even though I had a couple of pretty good months between July and September.

Lately, my spine makes strange noises when I move and I have the feeling that I`m extremely fragile. My nails, which had become very nice and strong in the first few months after Prolia, have again become extremely fragile and brittle. My skin goes through periods of being nice and soft and days or weeks of being rough, ugly and dry.

I never thought 2017 would be so horrible for me because of this drug. I retired from my permanent job two years ago and was beginning a new and very successful cycle as a self-employed professional. I have hardly been able to work since March.

I feel we have been used for a clinical trial without our consent. If you look at AMGEN's website, you will see that the list of negative side effects for this drug is continuously being updated…. Isn’t that a proof that they had not fully researched what they had put in the market? I hope we are at least compensated for the objective losses that we have incurred because of this killer drug.

I hope that my long message helps you and other potential users of this poison to not run the risk. All medications have a level of risk, we know that, but the risks of this one out-weight by far the potential benefits, if any.

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I am with you will never take another Prolia shot again. Itch all over with hives. I hope I don't get worst.

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Only side effects I have after 3 or 4 injections so far is my jaw pain, but it went away soon and my muscles ache quite severely to different parts of the body. Still after all the shots. Feels like severe arthritis here and there.

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I am sorry to read all the side effects. I really believe it caused my ovarian cancer. All my troubles started after the first shot.

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Prolia is a terrible drug! It has made me very sick, muscle, joints, digestive problems, skin rashes, blisters. Had my last shot Feb. 16, 2015. Will never take another one. Not sure My body will ever be then same!

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