Pain Medication Stronger Than Fentanyl (Page 2) (Top voted first)

At the hospital with heart and chest pain. Already on a Fentanyl patch and its not working. Is there anything stronger than the Fentanyl patch?

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What would b strong enough if I quit the opioids
If I were to come off of the opioids because I'm hearing a lot of dangerous things about the opioids if I were to come off the fentanyl patch and the morphine what can I take that would help me with this pain and be as strong or a little bit stronger than the fentanyl in the morphine together

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Re: Verwon (# 1)

There is one medication, however getting it is now impossible but it’s called cot-fentanyl. It is 100 times the strength of fentanyl. You must have a high tolerance.One sand of grain of it would kill you. It has to be delivered in micrograms.

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Re: lmciver (# 4)

Try requip for your legs. It helped me after 38 years of leg pain waking me every night!

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cucupuffs (# 5) -Opana is a very strong pain medicine my nephew takes it I guess I spell it right have you ever heard of it it is a very strong pain medicine and he’s been on it for years They give him 30 mg 90 a month and 60 Roxies month I am on 120 Percocets a month and I just get the where they not helping I’ve been known him for three yearsv I am on 120 Percocets a month and I just got where they not helping I’ve been on them for three years i’m 61 years old

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Re: Chris (# 20)

Hi Chris, I was on methadone year's ago
and that doe's work really good, but if you wanted to stop that, it's withdrawal is just as bad as opioid withdrawal, I have been on suboxone now for 4 year's, the best decision I ever made.

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Dilaudid IV. But with heart problems you probably can’t take it.

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I need a dr in Binghamton area for my medications fentanol and Percocet my dr went out with cancer and the other dr is not weighting he scripts for anyone any more new York Binghamton vestal plead help

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This is the strongest - even stronger than the last one and only should be used on large elephants and rhinos, another fentanyl derivative...

from Wikipedia:

" Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl. While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil.[1][2] This suggests that substitution at both the 3 and 4 positions of the piperidine ring introduces steric hindrance which prevents µ-opioid affinity from increasing much further. As with other 3-substituted fentanyl derivatives such as ohmefentanyl, the stereoisomerism of lofentanil is very important, with some stereoisomers being much more potent than others.

Lofentanil is very similar to carfentanil in effects, but has a longer duration of action.[3] This makes it unsuitable for most practical applications, with carfentanil being the preferred agent for tranquilizing large animals, and short-acting derivatives such as sufentanil or remifentanil being preferred for medical use in human surgical procedures. The long duration and high lipophilicity of lofentanil has been suggested as an advantage for certain types of analgesia,[4] but the main application for lofentanil at the present time is research into opioid receptors.[5][6]

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea, and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[7] Side effects from lofentanil might be particularly problematic given its reportedly long duration of action. Another side effect which is characteristic of fentanyl and its derivatives is their tendency to rapidly induce tolerance, due to their high binding affinity triggering rapid internalization of chronically activated opiate receptors.[8] This might be expected to be a particular problem with lofentanil as it is not only one of the most potent drugs in the series, but also is longer acting than most other fentanyl analogues, meaning that development of tolerance triggered by receptor over-activation is likely to be especially rapid, occurring with as little as a single active dose.

In addition to acting on the µ-opioid receptor, lofentanil has also been found to act as a full agonist of the ?-opioid receptor (Ki = 8.2 nM; EC50 = 153 nM; Emax = 100%).[9] "

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Of course, the patch is used more for chronic pain, even a hyromophone if would be better, or an i.v rent drip,

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I was given 150 mg of fentany patches I change every three days also the doctor gave me Hydromophone 8mg six three times...

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Dilaudid is a semi synthetic keytone or Hydromorphone HCL, so it is i feel its twice the potency of morphine, short acti...

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Which is stronger, taking morphine 30mg tablets or Morphine inj. 10mg ## Morphine gets you tired and has a heavy, unclea...

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I broke my ankle and foot on march 3rd of this year and it hasn't healed properly. I am getting much worst pain than...

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kidney stones ## For anyone else seeking such information, the preferred medication in most hospitals for IV pain relief...

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i'm taking 200mg twice a day of MS-contin and have been for many years for my severe back/leg/hip/sciatica pain but ...

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I know Fentanyl is supposed to be stronger than Morphine however it does not help me nearly as much! I wish so bad that ...

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Does anybody know any prescription strength sleep aids that are stronger than Melatonin? I have been using at least 10 m...

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if fentanyl is 80x stronger than morphine, how much morphine will I have to take if I'm on 25mg fentanyl. sounds sca...

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Is there an acceptable level of medication to be on and be employable? Spouse currntly on fentanyl 100, hydrocodone 500m...

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