Oxycodone/percocet Generics! Which Are Most Effective? (Page 2)
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Hello,

First, let me start by saying that I am somewhat opiate naive. I am not in pain management and hopefully won't need to be. I've had scripts here and there for norco and percocet. It is the generic percocet, or more specifically the oxycodone, i'd like to discuss here.

Over the past year i've had issues (such as a broken elbow, recurring kidney stones, and a staghorn lodged in my renal pelvis [kidney]), that have lead to several prescriptions for percocet from a total of 4 different manufacturers. Mallinckrodt 10/325, Amneal 7/325, Rhodes Pharmacy 10/325, and AuroBindo 10/325.

I've read a lot of reviews about the aforementioned generic manufacturers. The majority of them have been negative especially for Rhodes. Mallinckrodt and AuroBindo are the only two that seem to have, at least, a couple of favourable reviews.

I've got a new script for a week's supply of percocet 10/325. The primary pharmacy that I go to is Kroger (my local CVS carry Rhodes). Kroger carries the U17 Aurobindo which seem to help with pain but cause other issues; tinnitus, anxiety, drowsiness, agitation and at times nausea. Those are things I can deal with but I'd rather not.

Does anyone have any input on what they find to be the best generic manufacturer of oxycodone? I've read about endocet, actavis, watson, kvk, and others but none of them seem to be readily available in my area.

These are what i've tried in order from best to worst:

1. Mallinckrodt - good pain relief, seemingly no side effects, mild euphoria. (Unfortunately I cannot find Mallinckrodt anywhere around my area.)

2. (tie) Amneal/Aurobindo - Kind of a toss up between these two. They seem to work for the pain but have noticeable side effects. Auro (effects listed above) and Amneal both seem to cause anxiety/panic. Profuse sweating and itching have also been experienced with Amneal although not with Auro.

3. Rhodes Pharmaceuticals - I've read some horrible reviews for these. While I don't think they're as bad as some of the reviews, they were definitely very weak compared to the others i've tried. Sort of hit and miss though as one pill would make me feel high and another would make me feel sick (while not doing much for the pain). A plethora of side effects with these as well with malaise and dysphoria; the ultimate worst!

Okay now that you've heard my subjective opinion and rant, can anyone out there offer their opinion on these generic oxycodone/percocet manufacturers. Are there any generic brands I'm missing or never heard of? What's the most effective for killing pain with the least side effects? (I'm taking them for pain).

P.S. I'm going to have to fill at Kroger and get the Auro U17 regardless but would like to know for future reference. Thanks in advance! I'm in the Indianapolis, Indiana area.

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Re: Skip (# 121)

Thank you so much for your response!! I had no idea about how the meds affect you internally, could you send me a link or a better explanation on how my diet will affect the way my pain meds Work? I’m very interested in anything to better my quality of life. Should I just look up carnivore diet? Thanks again for your response, I appreciate it very much!

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ISE #101 & Annie #103 --

Annie, you are correct. Brand Name "Endocet" 10-325 (10 mg of oxycodone and 325 mg of acetaminophen was still available NDC # 60951-0712-70 tab were still available, as recently as 2017, they come in bottles of 100 tabs each, DEA class C-II. FDA Orange Book rating a "rare" AA, the "final step up", out of 17 different "lesser quality ratings" (actually 10 of the 17 FDA Orange Book classes are for quality control efficiency).

Endo Pharmaceuticals, Inc. (610) 558-9800 (Pennsylvania USA). the MAKER of the drug, (patent holder) not necessarily the SELLER of the drug, (some major big USA firms will "farm out" the proprietary drug, to a different mfg, to Endo standards, who actually mfg said drug, and, it's then offered to a drug wholesaler, with a DEA license, to market to USA pharmacies.

Source: REDBOOK (pharmacy's fundamental reference) edt 2017 121st year of publication, (now on the internet only) no longer published in textbook form, since the year 2010. "Endocet" brand name was listed as available also, in USA, Canada, and Israel, as well, (page 114) of the 38th edition of MARTINDALE (The Extra Pharmacopoeia) a/k/a "The Complete Drug Reference" info in 43 countries of the modern industrialized world, Pharmaceutical Press, London
UK, (ISBN 978-0-85711-139-5)

Endo Brand name Percodan was also still listed in the Martindale for USA citizens, but was discontinued for citizens of Canada. Endo has realized a significant increase in demand for USA C-II Opana and Opana ER brand name, directly due to the reformulation of Purdue Pharma "OxyContin" original formula, (1996 to 2010). Purdue OxyContin has realized a large decease in sales and a decrease in consumer satisfaction surveys, with their OxyContin "OP" embossment, vs. their "OC" embossment (old formula) of OxyContin (USA).

Opana (oxymorphone HCI). The pharmaceutical industry in the USA has changed radically in the past, 6 years, IMHO. Many reasons, Brand and Generic, the latter especially. It can be a daunting challenge to get a USA chain pharmacy to special order a prescription drug, written as DAW, due to, hostile rules and regulations, by corporate office, of many USA pharmacy chain drugstores. IMHO, the independent pharmacy, preferably an owner-operator, i.e. owner pharmacist, or a independent family pharmacy, that were once very common in USA, but, in the 21st century are a dwindling group of pharmacies. (depends on your geographic location), and other reasons, such, as many pharmacy/owner's retire, and, sell their pharmacy to a big USA chain pharmacy. In my 47 years of using both chain USA pharmacies vs, an independent pharmacy, I'd place my energy more in searching for a more co-operative, independent pharmacy especially run by a pharmacy owner. The downside, is, you may have to pay more money to get a special order drug, like, Endocet, if it is not normally on the stock shelves,due to low demand, (understandable) pharmacy needs to make a profit, to stay in business, and many Brand products often are very expensive I mean "very expensive"I know I have been there, like, 3 to 5 fold more pricey, and, of course, it is a small minority of USA insurance firms who will pay for an inflated price, so, only the "haves" in the USA can do this and the "have not's" (like me) have to take the leftovers, (often the generics) especially since the Obama Care Act was placed into law. I am not anti-generic necessarily, but, my attitude has changed in the past 6 to 8 yrs,
due to the greedy USA pharmaceutical companies. The truth is in the here and now the GENERICS vary greatly. yes the 80% to 120% FDA regulations are still in effect but,the bioavailability, (how our body metabolizes the fillers and binders), is what the generic USA mfg are manipulating that is the cause for "so many consumer complaints, in the past 6 years".

Bottom line, if you can afford it, you are good to go!, if, you cannot afford it, like the majority of USA citizens, you may have to take a far less efficent substitute, generic. FDA regulations, about Orange Book bioequivalence, is some help .....yes, but, the AA rated Orange Book meds I assure you are in the strong minority of drugs available. Also, the pharmacy MAKERS have the pharmaceutical sellers who sell the drug, and actually mfg the drug...well, often due to high pressure price point demands, the formula is modified, to lower quality standards, with more fillers & binders to meet the strict price point, or, the MAKER, will, not do any business with the drug SELLER, (actual mfg of the prescription only drug).

The Bio-availability is often overlooked by the USA consumer, which is NOT regulated by our lazy FDA. In the past 6 to 8 yrs, many drug ingredients, are purchased overseas, and, the USA drug manufacturers, they do their own self reports on the drug quality, and, many large USA drug MAKERS, often buy out smaller drug MAKERS, and, the quality can switch quickly, to increase profits, and, IMHO, gouge the public consumer, and/or, the drug MAKERS are very manipulative, and they often, own their own generic company, and/or switch or "farm out" a prescription drug, quickly, with a "merger", I have never seen so many mergers in my life as in the past 10 years!! JMHO. Source: FiercePharma and Bloomberg.

The only other choice, is not practical for many USA citizens, but, the brand names "across the pond" in Western and Eastern Europe, are, much less expensive, and, are very high quality, the problem is, two fold, one's mobility or ability to travel abroad, and, the USA laws that prohibit, the purchase of especially controlled substances, "by other means". I shall
plead the 5th amendment on what I define as "by other means".

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Re: Mandie (# 112)

Look into the carnivore diet. It eliminates all inflammatory food from your diet and it causes your body to use medicines more efficiently because none of the drug, well next to almost none, is stored in fat cells.reason being your body now feeds on fat for energy instead of carbs"sugar"..

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Re: ISE (# 111)

Actually it say do not drive or operate machinery while taking this drug until you know how it wi effect you

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I've been on Actavis 30mg Oxycodone for years. Now I'm getting the Mallinckrodt brand, but they've given me a terrible headache and a slight kidney infection. What should I do?

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Re: Mason (# 6)

KVK absolutely useless. After several failed back surgeries and chronic pain for the last 18 years, the last 8 debilitating today I went to a Frys (Kroger) pharmacy and received KVK oxycodone 15 mgs and they don't work. I had to switch Pharmacies due to Walmarts change in filling rules in AZ. At least at Walmart for the last 2 years I always received RHO and they worked great! Now to find another pharmacy.....

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Re: ISE (# 91)

If you take the 10mg pure oxy and take a small amount of tylenol it helps the pain a little better than on it's own. Recommended by an ER RN who happens to be a friend and in chronic pain. She said it makes her gag seeing the amount of pain medication that gets trashed (wasted they call) because the doctors have to start with a low dose and that's less than a vial in 99% of the cases.

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Re: Mason (# 105)

I completely agree with you so I must agree with Roro. It's naive to think that some in our government aren't profiting from all sides. Manipulating the market when it suits, being a provider of drugs not so legally crossing our border and controlling the manufacture and distribution of prescription drugs. There are too many instances that we've been lied to by the people we've trusted when we voted.
This was all put in motion before the last Presidential and Congressional election. We've got another coming up in November. Take time to get to know your candidates. It's likely that if you hear it or read it in the media it's untrue. We have to contact by mail and phone most assuredly the people who want your vote, also the agencies involved. Keep updating them on your condition so that you become a real person to them. Firm but kind gets their attention. Someone else had an idea to help get doctors and our other health care providers on board by showing them this site. Her doctor goes to DC on chronic pain patient's behalf. If we could organize a rally in DC before the Congress recesses in Aug or Sept, wheel chairs, walkers, canes or 2 able legs it would be great.

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Re: BobbyC (# 107)

I agree 100% No matter how much REAL pain you're in, you get get back. Very very sad....

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Big Red Baloon, you still out there? Has the world gone mad or is it the NEWS MEDIA? The fake news media is the blame for all of the madness in the world!!! A few POP singers die from a mixture of drug, they not only had the money to buy any drug off the street, they had the money to buy DOCTORS. Their deaths were on ALL the news networks for months and none of them told the truth of what drugs they died from until a year later (illegal drug) and a mixture of them with alcohol. The fake news caused the OPIOID crisis with stories like LITTLE JACK and JILL climbing up to maw and paws medicine cabinet and got their opioid and became addicts and the VA is handing out opioids like candy and they are making their way on the street. Vets can't get pain meds anymore. Now they have caused another problem - school shootings by their coverage and the attention they give to the shooters. Will the government do away with school or will they go after the real problem to make schools safe? The government can't stop illegal drugs so they go after prescription drugs and doctors that write them, hell they are easy to find. The DEA is not smart enough to catch drug dealers so the DEA and the fake f***** news blame it all on prescription opioids. Drain the swamp and stuff a dirty sock in the fake news media's big f***** mouth and the world will be a better place. Come to think of it, the world started going downhill when CNN started 24/7 coverage. Now they all do it and that's how FAKE news started. Give me a shout back Big Red Baloon.

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Re: Roro (# 102)

"It is not a drug issue, it is a behavioral issue." You centered on the real problem. Without that, nothing can be solved or prevented. I know the pharmaceutical business is for profits. If normal people just prevented the cause (easily done for most circumstances) they would be out of business.

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Re: David (# 7)

Hi David, I’ve had chronic pain for about 18 yrs, I’ve tried just about everything because my tolerance went up and they stopped working. A couple things they did (Pain Management), I took, what they called a “Vacation” from them. This was to lower my tolerance back down. I think they gave me Suboxone while I was off of them. Another was getting back injections, they don’t just work for your back, but other parts of your body. Just be careful about the steroids, I ended up with a cataract in my left eye. But, mainly I would try to go off of them for awhile yoblower my tolerance, this was very difficult. But, the last one I am in the middle of, they’re doing a “Spinal Cord Stimulater.” This is a surgery procedure where they attached wires to your nerves in your spine and it blocks the pain before your receptors get them and tell you your in pain. Ask your doctor if this would be an option to help, it’ll take you off the pills, which after awhile will do damage to you internally. I hope this helps, I was approved for the trial to make sure it works! I don’t want to have the surgery and realize it doesn’t work. Good Luck and try and look forward with a positive attitude, it helps a lot!!

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Re: Roro (# 102)

I know I need Opioids to function and I can't without it. I do believe that everyone should be on an Opioid Agreement and randomly tested. If you are out driving a car and expect to NOT take additional responsibility by being on these medications which BTW- do state No driving while using. The least you can do is go by proper channels and get the medication by DR's who really know these meds. What I do NOT like ARE the changes that they're making.... YES IF YOU READ THE ARTICLE THE PROBLEM IS A COMBINATION OF PRESCRIPTION DRUGS WITH SUBSTANCE DRUGS EX... HEROIN...

I am not talking about example---- I take 5-10 mg Diazepam [Valium] at bedtime. It used to be 5mg twice a day and 10 mg at bedtime because I have Anxiety/Depression with a Resting Heartbeat of 115 beats/ minute. [Now imagine how much higher my heartrate will go up once I go off Diazepam completely ... my Dr has been telling me I have to wean off this. I have tried taking none and I use my rescue inhaler which until now. I only used 3 times in 14 years. Everytime I do not take my Pill I need my inhaler. I seem to induce anxiety asthma attack? That can not be good.

I did stop taking Ambien CR because of Sleepwalking a couple years ago which BTW- saved my life. I had a fall. Had a MRI of my C-Spine and they found a suspicious lump. So they sent me to go see me to an ENT Found I had Obstructive Sleep Apnea. Unfortunately, the lump can't be removed, biopsied, only scoped every watched. Lingual tonsils are tricky. They control the tongue, esp. The nerves of the tongue. 6 weeks of feeding tubes and more risks. The ENT said unless it completely closes off my breathing. It is something to live with. They switched me to Belsomra and worked like a charm. Hard to fall asleep initially with a LOUD CPAP thing on your face and a fear that I will be strangled by the hose. Oh, and with allergies you can't use it. So, everytime I fall asleep I wake myself UP afraid I WILL stop breathing. So try falling asleep with NO Belsomra or Diazepam. This is the New Rule... no Opioids with Hypnotic sleep medication or Benzodiazepines. Even though, I am on such a low dose.

The problem that is really going on....... they are making it harder for people to get their medication. When my Dr left my insurance and for those months.... if I was desperate and well really desperate and what the article is talking about... people turn to street drugs on top of it... HEROIN.

The Gov't and DEA isn't thinking here and This is what I think people are going to get desperate... Personally, I wish they would stop fighting and just legalize Marijuana across the US. It has been proven to do a lot already. The other option IS CBD oil. So many emails for those trials.

Well, the DEA & Gov't believe WE are in an Opioid Epidemic... I came across this and figured I would copy & paste it. I agree with this!!

Think of all the famous ppl that died from prescriptions alone- Brittany Murphy, Heath Ledger, Anna Nicole Smith, Michael Jackson. [Propofol -ok- never should have been given. Conrad Murray administered it to him and then left him to make a phone call? Seriously? He's already out of jail! I just hope he never practices again!! He should still be in jail!] Prince [Fentanyl - not the RX strength the man weighed under 100 pounds] Ok- This is serious stuff! He was soo against drugs until he busted his knee, Keith Moon [The Drummer - The Who] and I will not include the suicides.

Source: "The truth about the US ‘opioid crisis’ – prescriptions aren’t the problem", theguardian.com. Web. November 7th, 2017

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Re: Cathy (# 92)

My Dr switched me to Dilaudid [Hydromorphone] 4 mg 3 times a day and I will tell you and 15 mg Morphine Sulphate and OxyContin ER twice a day. I switched Pain Management Drs. These meds so far are so much better than Percocet. I know I am nearing my switch time soon phase but I am getting my 1st back injections with this office so might not be switching so quickly. And I don't think I will need to switch it up yet. He's doing Radio/frequency Ablation lumbosacral L3-all the way down. Both sides. I have had it done before. It hurts like hell and Gets worse before it gets better but it lasted about 7 months and I know it did something because when I wore off The pain was OFF the charts!! I had NO pain Management Dr and had left over meds fromwhen I went back east to my brother's Engagement party & then Wedding I was smart and put the pills away that I didn't use. We stayed at the same hotel- no driving, spoke to the Dr ahead of time signed waiver about Alcohol responsibility and narcotics.

No dose before any drinking and wait at least 3 hrs unless you STILL Feel the effects of the alcohol. He gave me a breathalyzer to take before meds. If DUI level before bed you skip dose and you must turn that one in. He has the serial # so you can not buy another one to take at a later date. I had one glass of wine at the Engagement party, had a Mimosa getting ready for the Wedding at the brunch and a glass of Champagne at the dinner making a toast to my brother. The Breathalyzer came back all clear... Actually was a good thing that I had some pills left over half here and there -eventhough my pain was excruitating and verging on 9.5 with tears in my eyes and crying myself to sleep EVERY night till I got another pain management Dr again. With a regular schedule which in AZ is not easy on NOT EVERY DR WILL GIVE OPIOIDS!! Not a PCP, my Rheumatologist used to give me those meds in the past about 5 years ago w/ a narcotic agreement. I was always on. Thanks to the NEW RULES!! Nope!! I can not afford the copay to run to the ER- every time because you know they give a limited amount of pills. Besides, who wants to look like a "drug seeker" or feel like a criminal?? Bad enough my first experience with pain management that IS how you feel. First time you go.. it really was not a pleasant experience. However, I found a great Doctor and he is on the Top Doc List 3 years in a row!

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Re: ISE (# 94)

You got that right!! Well said Roro. It is good to hear from informed people.

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Re: Annie (# 103)

Riteaid is not in Arizona! You can look for yourself and My Docs have written DAW [Dispense as written]! Why would the Pharmacist lie? Besides she has shown me the manufacturers Drug book herself. They can not order them in 10/325. It said they were discontinued.

I have Cigna Medicare Insurance which allows me to use their Pharmacy- WalMart, Osco [Albertson], Walgreen's, Safeway and some others so far ALL OF THOSE HAVE SAID THAT DOES IS DISCONTINUED BY THE MANUFACTURER.

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Re: DR TIM (# 96)

Been there done that dr. Tim. Where do you get your 10% upgrade or increase stats from? I do agree with you on the pharmacy doc/police. But when it comes down to it, some of us need opiods for pain relief. I asked my p. m. doc to cut down on the amount & dosage of my meds. He was supprised. But explained to him that I see that big train of ' I can't prescribe any more' coming right at me. So trying to ease off now. It's been a b----ch the last month. Seriously thinking of leaving this earth early. Been taking that crap for 27 years now. Pretty hard to fool or fake injuries to docs over the years one would think! Can't believe that the ' powers that be ' are doing this to us. They have the opiod death stats wrong! Hang in there everyone!!

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Re: Mason (# 104)

No worries. My stones, well the first two that I had 14 months apart were uric too. 500mg of magnesium a day, its been three and half years, no stones. I also stopped drinking tea every day. Drink it once a week. You'd be surprised at what natural "helps", not cures, there are for things doctors simply will never tell you. But, I hope you have a handle on it. If your blood, and other fluids are acidic, I would also recommend coral calcium supplements with at least 2 hours of sun on your face a day for the natural vitamin d. Blood becomes acidic because your body uses more calcium than it can absorb. Coral calcium is "pre-digested naturally" by the organism that make the coral......oh well, that's all the info that's applicable to your situation. Look into it you're the type that never settles for one avenue to success. Godspeed.

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Re: Roro (# 102)

I completely agree with you. As a former USAF 15WX attached to a small Army spec-ops unit in Afghanistan; I can tell you first hand that the security of those poppy fields are of utmost importance.

It is quite strange how heavily guarded those poppy fields are by our military. Since taking control of the majority of them pharmaceutical grade opiates have taken a mighty plunge in efficacy and a major jump in side effects. I hate to sound like the conspiracy theorist but let's not forget what our government has done in the past. MKULTRA comes to mind.

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Re: skipbond (# 88)

I've been taking potassium citrate (Urocit-K). My stones aren't common, they're uric acid. The Urocit-K helps to balance the PH of my urine so that it's less acidic and more alkaline. This prevents the uric acid from building up to form stones. I also supplement with magnesium for other reason related to healthy brain chemistry/activity. Regardless I had a ESWL procedure and the issue has been resolved. Thanks though.

Dr. Tim (# 88) --

Having a handful of prescriptions for legitimate reasons over the period of a year is hardly chronic nor even nearly enough to build a tolerance. You're apparently not a doctor of any sort (not that your lackluster writing didn't give you away). It doesn't take someone with chronic pain to notice when medication is not effective and causing unpleasant side effects.

I am opiate naive in the sense that over my 40 years on this planet i've taken, in total, maybe a total of 2 months supply of opiates spaced out over years. I've never had more than a 7 day supply. I'm not in chronic pain. Your holistic approach is all nice and dandy for some pseudo-intellectual hypothesis. Simply asking a question on a medicine website does not equate to obsessing. What does some obsessive is the ignorance in your reply.

I'm talking about dealing with acute pain. I'm not trying to get into some protracted discussion with some judgmental blowhard (You, Tim) about intense pain brought on as a result of short term injury/complication. This type of, acute, pain cannot be controlled through an EEG (biofeedback) or by seeing a pain psychologist (what a pseudo-science). Thanks for your input but quite frankly it's just a waste of cyberspace; void of any substance much like that space in between your ears. ;)

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