Lisinopril And Bactrim

I have taken amlodipine and lisinopril for a few years. I recently got a staff infection and my Dr prescribed bactrim. I have heard not to take bactrim with lisinopril. Is this true?

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Hello Sally,

You are absolutely right! Lisinopril has been reported to have a negative interraction with trimethoprim (Bactrim). These medications used together may increase the potassium levels in your blood which in turn can develop into Hyperkalemia. In severe cases this can lead to kidney failure, muscle pralysis, irregular heart rhythm and cardiac arrest. You are more likely to develop hyperkalemia if you are elderly, dehydrated, have a kidney disease, diabetes or if you are receiving Bactrim for long periods of time.

Reportedly it is important that you maintain adequate fluid intake during the time you are administering these medications. It is cautioned that you should limit your intake of potassium rich foods such as tomatoes, raisins, figs, potatoes, lima beands, bananas, plantains, papayas, pears, cantaloupes and mangoes.

Please consult your doctor if you experience any of the following symptoms as they may be symptoms of hyperkalemia.

- nausea
- vomiting
- weakness
- confusion
- tingling of the hands and feet
- feelings of heaviness in the legs
- weak pulse
- slow or irregular heartbeat

If you are uncomfortable with possibility of developing hyperkalemia please consult your doctor. Do not stop taking the medication until you have spoken with your doctor.

I hope that this information helps you.

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