Linzess Stopped Working
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I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating!

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32

YES! I bumped up to the 290 dosage and it’s no longer working.

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31

I have been on the 290 mg for 18 months and it was great to clean me out ; unfortunately , it would take 6 hours or more to work . And also I had to make 3 - 5 trips to the bathroom to finish and I always have watery bowels with the 290 . But , it fells GREAT when It's over !!

Now ,being a 81 year old retired mechanical engineer , the 290 just STOPPED DEAD working 6 days ago . Today my bowels finely worked nd was loose ,; but , not diarrea

I have an appointment with my doctor in 2 days to get checked out because the 290 stopes and to tell him that I believe that I need another Colonoscope because of some sharp pain in my colon sometimes and all of the bubbling in my colon plus I had Colitis 11 years ago and lost almost 50 pounds because of the colon infection !

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30

YES! I've been taking linzess with 5 sennakot and stool softeners,it would work with diareah of course,but after 5 weeks it just quit.Left me with incredible gas,cramps and bloat. This drug is a nightmare.I don't know how I'll make it through the day.I've been diagnosed with redundant sigmoid and CIC. I'm in big trouble because I must wiork in misery

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29

Same here have been taking it for 3 months the way i am suppose to take it and it just stop working call my Doctor told me to continue taking it nothing change He told me he has nothing else to give me that's crazy

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28

Re: Andrea (# 20) Expand Referenced Message

Andrea,

I have also started taking my linzess 290 with a laxative in the am. As many have stated, my prescription on linzess started off great (Id rather be wed to the toilet going, then constipated and in pain) but after a year, its efficacy has stopped working. I feel hopelessly devoted to laxatives again. Sometimes the otc laxative works in combo with the linzess but this is unpredictable. Does anyone find that switching to dosing in the evening much better or increasing the dose to twice daily better than adding an otc laxative? Any suggestions would be appreciated. I have been slowely becoming more crippled by the chronic pain of ibs more than ever recently. i work in surgery- i am 33 - and extremely health conscious, but there are days that i am in so much pain now that i cannot stand and operate all day anymore. I fear that the disease has become a true threat to my career and livelihood

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27

I have been on 290 and now it's not working, I've been on it for 8 months. Sometimes it would take 3-4 days before it worked. But it's been a week and not doing what it use too.Has anyone else had that happen. Now I feel so bloated I don't know what to take.sue

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26

I was on linzess the highest dose it worked for about a month My doctor told me to take 2 Ducolax every two days if no BM yes that worked until I was down to 89 pds from ducolax cleaning me out ! I stopped linzess and I am going back to my Gastro and asking for a better way Linzess is garbage and I was getting bad sinus infections from it when I stopped my sinuses got better !! There has to be a better way then these docs pushing laxatives on Us ruining our gut in fact if you read on here people who say it works there taking something else with it . From anyone I talk to they say it just stops working after awhile To everyone good luck Zelnorm was the only thing that worked and they pulled it off !!

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25

I've had chronic idiopathic constipation for 10 years. I just started the 290mg. Linzess 2 days ago and so far nothing but bloating. Is it fair to say this med will not work for me at this point? I did follow the directions appropriately.

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24

I have also been taking Linzess for 5 months now because I was diagnosed with IBS-C. For the first week of taking a Linzess i felt relief 2 hours after. Since then I've been bloated and constipated. I feel terrible. I took Linzess 290mg. NO RELIEF.

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23

I was on Linzess 290 for years and it worked well. Had to take it at 1 AM so I could wake up and go. Had to stop 6 months ago because it got too costly. Took laxatives and stool softeners and teas. They stopped. I just started some other meds that cause more constipation-great. So I'm going back on Linzess despite the cost. I hope it still works.

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22

Thank you! I'm in the same boat with y'all, will give this a try. Sure would be cheaper than the Linzess!

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21

I have been taking linzess for about a year. first on 125 mcg and after a few months 290 mcg.I now have not had a bm in 5 days curious.. what is smooth smooth tea?

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20

I am still taking the higher dose of the Linzess, along with one OTC laxative. I wait the full thirty minutes before eating; fifteen minutes after I take the kinases, I take the laxative. Lots of water drinking going on!!

I do this every two or three days, depending on my schedule. I carve out the days I take them so that I can stay home. Being retired helps. My gastro-doc knows what I take, as does my doctor. My last colonoscopy showed discolor of the colon, which I have researched and found it to be nothing to worry about. Laxatives cause it. No matter...I can't change my regimen. I've adapted my life to this and, after all this time, I'm doing fine with it. Good luck.

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19

I have been on Linzess 145 for about 7 months now but it does not not work by itself , I still have to take one capfull of Miralax every night and that helps me a lot. I was already taking Miralax before and the reason my dr. added Linzess was so I could empty my bowels more quickly, like going to the bathroom at most one or twice. I still have several bowel movements a day but is is better than when I was only taking Miralax where I had bowel movements 5 times in the day. For some reason I don´t empty my bowels with one time. I don´t have bloating or cramps so I am relatively happy. I suffer from IBS with constipation and I have a small rectocele. If anybody can suggest something better, it would be great.

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18

My Dr switched me to Amatiz low dose once a day at night with food. Not much help. I gave myself a mini clense with magnesium citrate. Went regular for one week. Again back to being backed up. I have another appointment. My colonoscopy showed that everything was good

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17

I started out with 145 and nothing for a week. Dr gave me 290 and worked every 5 or 6 days then stopped. Started taking a 290 and a 145 and would have a normal bowel movement once a week. Now that doesn't even work. Even tried adding a laxative before bed.

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16

I too have taken Linzess for several years and 6 weeks ago it abruptly stopped working.I am beside myself .I resorted to many OTC meds including an enema which FINALLY brought results. Now what?

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15

I had the same exact experience I have idiopathic constipation Right now my Gastro took me off Lynzess I am taking smooth smooth tea and two stool sofners The Dr suggested trying he tea again with a stool sofner I am improved Moving more reguarly Still a bit bloated The teas cannot be taken everyday Good luck

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14

Yes for me too now i use mineral oil and it works good

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13

Yes i have been taking 145 linzess for some time now and it was working but now it has stopped. My gas doctor seems to think it may be a bowel blockeg I will have further test and get back to you

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