Linzess Allergy

I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time, I was still hopeful. However, I woke up on a Wednesday with a swollen face and a bump in my eyebrow. I thought I had gotten bitten by something and didn't attribute it to the Linzess. Took Benadryl but didn't get any relief. I woke up with my eyes swollen almost shut on both Thursday and Friday morning and the bump in my eyebrow began to itch. By Saturday morning when I awoke to a swollen face and eyes again, I knew it was the Linzess. I am bummed since I was so hopeful that the Linzess would help me with my constipation.

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Oh wow! I am so very sorry about what happened.

Did you consult your doctor? Has swelling gone away, yet?

It is always possible to find out that you're allergic to anything, though it sucks that it was a medication you had such high hopes for. Generally, swelling and itching are signs of an allergic reaction and signal that one should stop taking the given medication and seek medical attention, according to the FDA.

It's astounding that Benadryl didn't help, since that's what most ERs use as the first course of treatment for an allergic reaction.

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I did speak with my doctor this morning and he said that he is more inclined to think that my swelling was due to something else and not the Linzess. However, he has advised me to stop taking it for one week and resume the medication on next Monday. The area over my left eyebrow is still slightly swollen; not as bad as it was and the area within my eyebrow feels like a hard lump. I am hoping that it was something else and not the Linzess and time will tell.

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I too had one single lowest dose yesterday. Within 6 hours dizziness, weakness, random itching over entire body, swelling, hives, tingling of ear, neck, face & lips. Itchy eyes. Took benadryl and Zantac, called on call GI doc with my epipen in hand. Told to go to ER where they added steroids to the mix. Thankfully no need for epi then. However now I barely slept last night from either going to the bathroom to have a BM, or waking itching and much increased irritation in my airways now. Doc said allergic reaction to this is one in a million but it is possible..after finding here 3 others with a reaction I think they're grossly erroneous in their published statistic for it. Oh I also have had a full headache since late yesterday afternoon preceding the reaction which is reported as common (1%-10%).

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I,too, had hives on my face after one dose of linzess. My PCP who prescribed it said it's not listed as a side effect so it wasn't linzess. I stopped taking it in spite of his advice. When the hives subsided after about one I took one more dose and sure enough hives again. When i saw my GI Dr. he said I should not take it. After reading these posts I'm so glad I stopped before the reaction worsened. This forum is so helpful.

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Has your GI prescribed a different medication? It clea that the allergic reactions are happening to more than they claim.

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Has your doctor determined a new course of action?

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I tried linzess several times and it always gives me severe headache and swelling .

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Re: angelmay (# 7)

Same here. Severe back pain stomach bloated and severe pain also broke out all over my face. I was on the highest does for a month. And with all that I only had one small bm. I went to my sons and forgot to bring it so I was off of it for 3 days and felt So much better. But I don’t know what to do now I still have severe constipation!

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