Keppra Problems

My husband was put on keppra about two months ago. He slept day and night for about a week and a half. He's awake alot more now but when he's up he's in a bad mood or just indifferent. He's been on seroquel for years to treat bipolar disorder. He was in a bad mood alot before the seroquel and then he was great. Now that he's on keppra he's in a bad mood alot, like its reversing the seroquel positive effects. The Dr said he'd wean him off so I'm hoping for the best. He didn't mention prescribing anything else for seizures so I am worried he will start having them again. Any comments or advice?

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Hello, Sunshine! How are you?

Keppra is actually well known to cause such personality changes, I'm surprised the doctor didn't warn him about it. My husband went through the same thing, but his doctor had warned him and switched him off of it, immediately, when he told him about it. He is now taking Oxcarbazepine quite successfully.

It is also an anticonvulsant and the FDA lists its typical side effects as possibly including nausea, dizziness, memory problems and dry mouth.

He was also just able to do a clean switch, rather than a taper, since they are in the same medication class, so your husband may want to ask his doctor about that.

Does anyone else have any advice to add?

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