Dee Says:
Inactive Ingredients Of Qualitest Or Leading Pharma Lorazepam (Top voted first)
Updated
winjy Says:
What are the inactive ingredients of Qualitest lorazepam or Leading Pharma lorazepam? Does anybody know?
It seems that its formula might have been changed because I feel 1mg is less effect than before or does not work. I used to take Ativan 1mg before abroad and one month from Kaiser in the U.S. but they gave me refill as generic lorazepam (Qualitest). I felt 50-60% effectiveness compared to Ativan(brand lorazepam). I can't take Watson lorazepam as it does not work for me causing side effects (rapid heart beats, sweating, anxiety, dehydration). Qualitest has less side effect (less dehydrated than Ativan) I did not have physical dependence on Ativan for long time and quit too. But this generic lorazepam is getting less effective over a few months.
Also my pharmacy had changed Qualitest to Leading Pharma without notice so I had to get new transcript for new pharmacy for qualitest (I transferred once).
I did not take it for mental problem (anxiety or panic attach) but for side effect of levothyroxine (I should take it as I got my thyroid gland removed). Ativan has calming effect and reduces heart beats, sweating, and stiffness and helps sleeping a little as I suffer from some pains. It does not fix my problem but reduces temporarily. Zanax does not work. Cymbalta does not work. All depression medicine does not work. With Cymbalta, I became unconscious and was hospitalized. I almost died taking Prozac due to side effects and worsened my symptoms. Ativan only helps a little.
I called most pharmacies in LA but many of them sell Leading Pharma lorazepam and some sell Watson. Most pharmacies do not receive return once it is opened (only one pill is taken) while Rite Aid does and during the period of medication, patients can't buy another lorazepam even with new prescription so if the medicine cause side effects or does not work, customer have to wait until refill period comes.
I found only one pharmacy selling Qualitest lorazepam but most others sell Leading Pharma, I don't know why but maybe because of their marketing. So I may change to Leading Pharma but am worried that it does not work like Watson.
I wonder if anybody tried Leading lorazepam and if it works, though effects are different according to each individual. Ativan in the U.S. is very expensive ($2600 for 1mg 30 tablet) and most doctors do not prescribe it and insurance is mostly not covered or do not want to pay for it. That's why Kaiser gave me brand Ativan only once and changed it to generic.
114 Replies (6 Pages)
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I was just given Leading brand and it doesn't work at all. I was on Qualitest for years without problems then CVS switched to Sandoz or Activis (same), and they couldn't order from Qualitest so I switched pharmacies. This Leading pill has a sweet taste and doesn't work at all. I heard they can remove 20% of the main ingredient. I've been on this medication for 10 years, this is awful..
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Savannah Says:
I was on mylan brand of lorazepam for the longest time. It worked so well. They are no longer making it and I have been given leading Brand. My doctor wants me on strictly Ativan brand and he will fight for me but it’s going to take awhile. From the leading Brand I feel horrible. Headaches, diarrhea, nerve pain and the list goes on. It tastes like a sugar pill. I’m literally in bed with this garbage. I don’t understand why you get good generics and then they are gone. Teva worked well for me, ranbaxy worked well and mylan. I use to take Watson and had jaw pain continuously. I had been given Actavis recently and my hands were sweating and I felt anxious within an hour. I truly wish I did not have to be on these meds but it’s been so many years I do not have a lot of choices. Someone needs to speak up for us! We need good quality generic drugs. I do not care what anyone says, the inactive ingredient and active ingredient are not the same with every manufactured drug.
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Judy Says:
I just sent back leading pharma lorazepam to be tested, as it was not effective. I noticed adverse reactions within a week of taking it. Usually I take Watson or Sandoz with no problems.
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Deedee Says:
I know exactly what you’re going through. Qualitest did work fine until the last few months when my pharmacy told me as of last July, they no longer make this so I did my research and found these cheaper companies are allowed to cut the main ingredient by 20% to save costs. You have to do your research and find companies at the top of the chain of manufacturing and try one at a time until you get one that works. Mylan has worked much better for me. But, the big chain pharmacies won’t order for you. You need a smaller family owned pharmacy that will cater to your needs. Good luck!
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Judy Says:
I can't take Leading Pharma lorazepam it is not as effective. Ended up in ER.
Watson or Sandos works best for me.
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Richard Says:
Re: Judi (# 19) 
So should I presume that NO ONE has had good results using Leading?
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Deedee Says:
Leading pharmaceuticals for lorazepam. I also had similar problems and found a local pharmacy who will order Qualitest for me. Rite-Aid, CVS, Kroger or Meijer will not order Watson or Qualitest. I found out Leading, Activis or Sandoz have cut the main ingredient by 20% to save money and this is why it doesn't work any longer.
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Judy Says:
Re: winjy (# 8)
It's about price. I had a problem with Leading and can only use Watson or Sandos for Ativan.
CVS uses Leading. Didn't even notice but I started having reaction to the meds. They don't work for me. I think they are less potent and I start having withdrawal symptoms.
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David Says:
Top Answer
According to Dailymed (NIH), the inactive ingredients in Qualitest's Lorazepam (NDC 0603-4246) are as follows (and remain consistent across all of their available dosage forms): [1]
- Lactose monohydrate
- Magnesium stearate
- Cellulose, microcrystalline
- Sodium starch glycolate type a potato
They also list the inactive ingredients in Leading Pharma's Lorazepam (NDC 69315-904) as follows (and they too remain consistent across all of their available dosage forms): [2]
- Lactose
- Magnesium stearate
- Cellulose, microcrystalline
- Polacrilin potassium
Hopefully this helps pinpoint the inherent differences between these two manufacturers. Personally, I've never even heard of "Polacrilin potassium", but my research says that it's used in pharmaceutical formulations as a tablet disintegrant.
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Judi Says:
Richard (# 13) --
I had to stop Ativan from Leading. I starting having panic attacks. Talked to them in New Jersey and sent back my prescription to be tested. They said nothing wrong. BUT was told by my Doc that these drugs can be as much as 15% difference. So I had started going into withdrawal. Watson and Sandos work fine for me. West Coast. There is a reason why Leading Pharma doesn't charge as much as Watson or Sandos!
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Judi Says:
Re: Judy (# 9)
Interesting. I was using mail order who used Leading. Switched to CVS and didn't pay attention to the Mfg. until I had an adverse reaction. Back to using Walgreens or Walmart who uses Sandoz or Watson.
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Judi Says:
Re: Richard (# 16)
That's interesting. I went back and read older posts. Some say it can be 20% off. Not a good thing when it puts you into withdrawal.
Recently tried to taper down. Not a good ecperience.
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joe Says:
Don't know if you're aware of this, but your local pharmacy could care less what works for you or any other person. I have been told time after time they buy the CHEAPEST medication, period. When i was living in Hawaii, I had used Actavis with no issues, and you could get it anywhere. The low lifes at sandoz bought the actavis brand and IMMEDIATELY watered it down to a sugar pill. Thanks to a few, we were able to expose this company for who they really were, and after changing the formula a few times and failing, i am happy to say that sandoz is no longer in the Lorazepam business. All i can say is trying what's out there till you find the one that works for you.
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Done Says:
Leading is pure garbage. My pharmacist let it slip that they order only Leading now because it's cheaper for them to order but still price it the same without passing on the savings to their customers. I now continually feel. I noticed the difference immediately without realizing l had been switched to Leading. I called all the pharmacies around me. They all jumped on the Leading wagon. I'm betting they are receiving kickbacks. I am starting the process of weaning off of Lorazepam. The side effects from these manipulated generics will kill you.
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Done Says:
Re: Richard (# 20)
No good results is putting it mildly. I immediately became sick from it. It's as if l am going through withdrawal symptoms without the benefit. My pharmacy switched me from Teva to Leading without telling me. A few days into it, l looked at the pill bottle to see if they gave me the wrong prescription. That's when l saw the manufacturer was Leading. They refused to exchange it and my doctor said l would have to wait until my next refill. Now all the pharmacies are only selling Leading in my area. It's cheaper for them to purchase. It's all about profit for them.
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Saw Says:
Re: Abbey (# 4)
Found this since im googling about the qualitest and my pharmacy just told me they aren't making them anymore. They gave me TEVA and I felt awful! Depressed yet wide awake. I take 2 mg a day (sometimes 1.5) just to feel like myself and get rid of the anxiety. I'm really paranoid about finding something that's going to make me feel right. I only have a few of the qualitest left and very nervous of going through withdrawal. I refuse to take the TEVA again though! It was absolutely awful. Anyone have any advice on a brand that is like this one?
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winjy Says:
Re: Deedee (# 3)
Thanks. My local pharmacy recently changed from Qualitest to Actavis (Watson). So I have to transfer. Most pharmacies here sell leading or Actavis. Could you let me know what pharmacy you use for Qualitest? I would appreciate the pharmacy info (pharmacy name, phone #, address). I am suffering from side effects of Levothyroxine so I take Ativan (lorazepam) for anxiety to reduce side effects of levo. No other medicine like Xanax, clonazepam works other than Ativan. So desperate. I don't know why pharmacies change the manufacturer very often and does not let customers know. And most pharmacies do not allow returns (other than big pharmacies like rite aid) and one transfer for lorazepam is possible. The stupid thing is once I receive my refill I should wait until the next refill even. In the case I have side effects from Lorazepam or it does not work at all? So I have to change the medicine or prescription. I called almost all pharmacies in my area (LA) and I can't find any to deal with Qualitest. Maybe Kaiser sells it but only Kaiser members (with their insurance) can use Kaiser pharmacy.
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Peanutsmom07 Says:
Re: Abbey (# 4)
Did your doctor put on your script that the med brand is medically necessary? If not that may help.
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Richard Says:
Judi (# 14) --
At Costco...Leading costs more than Watson......so I thought..hmm...it must be better....now Pharmacist can get me Mylan but I have to wait 3 months!
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Deedee Says:
Re: Richard (# 20)
Leading is total garbage!!! I’ve been having severe panic attacks for years and never had problems until they switched me from Qualitest to Leading. After one month of having no help whatsoever and it actually tasting like pure sugar, I did my research and found out Mylan was the only reputable company making this. They’ve been on nationwide backorder so I tried Watson which I thought was a good company until I just found out that Sandoz bought out the rights to make lorazepam. It’s an absolute mess right now. I contacted Mylan and they’re supposed to start making again by the end of May.
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