Hydrocodone-acetaminophen 10/325 By Mallinckrodt (Page 9)
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My pharmacy changed my meds from the yellow 10-325 v 3601 norco to the 10-325 white m367 mallinckrodt. I've been taking the yellows for years with no problems. Today I started the whites and feeling dizzy, a little weak, kind of panicky. What is different about the two meds that would cause this?

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I think the fact that you been taking the yellow and are use to it. Change pharmacy I did when mine ran out, and another one had the yellow norco 10. There is a diff, if you put 180 pills of yellow up against some of the white 10/325 pills there bigger. And are diluted down, not all of these generic pain meds meet the standard. But that's what insurance pays for, or we pay full price. This is what I think!

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I found a pharmacy in Irvine Ca. that carries Qualitest. They will not take insurance for this product, but will for the Tris. They carge $1.50 per pill for the Qualitest Hydrocodone 10-325. Don't know if my insurance will reimburse, but find this policy odd and troubling. Any comments?

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Oscar Western Vista, all hydrocodone and acetaminophen combination drugs have the same active ingredients. The fillers and binders vary from one company to another. Generics must have
8 mg-12 mg of the active ingredients, if it says it has 10 mgs on the label.

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I honestly do not know. All I know is that there is very little regulation on additives to generic drugs. Generic Hydrocodone MUST have at least 7 to 10 mg of the active ingredient.

When I took this drug, I immediately went into a massive allergic reaction.

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Mallinckrodt hydrocodone has a different formula on the bottle label on the bottle of qualitest Norco formula I found it once on the internet but I can't find it again but I did find it once

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Watson company has recently been bought out, BUT the yellow pills are still available. Your doctor CAN order the yellow capsules, which means that the PHARMACY -- if they want to keep your business -- WILL order those particular meds.

However, I believe the day will come when a legal case is filed against the company because of all the problems with it.

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I know I can't believe what's happening, it should be illegal, they regulate the meds so much these days, why not regulate what goes in it, regulate the fillers that are making people sick, why are we getting ripped off! Why are we buying our meds from other countries! This is a total nightmare for people whom live in pain everyday!

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I think the Mallinckodt hydrocodone is horrible. I much prefer Qualitest.
Any thoughts?

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I went to my doctor, and he prescribed (and any doctor can specify this) that the tabs be the yellow oblong ones. Watson was recently bought out by another company, but the medication is the same. I have contacted my attorney.

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I was switched from a yellow pill (pharma unknown) to a white pill a few months ago that is made by Tris pharma inc. I never considered all the problems that I am having being related to the change. Yes, my pain is so much worse, but I am having bouts of high blood pressure (pain and anxiety both cause this) and have had to take xanax to relieve it. I have xanax but usually did not have to take during day, just to sleep. Stomach problems are worse, severe constipation, having headaches. When I googled generic Norco, I have found all kinds of comments about it being of quality. Very interesting comments here. I was unaware of the FDA regulations. However, it crossed my mind that with the big opiate abuse problems, it is not unrealistic to think that ingredients could not be substituted during compounding. Hey, the coast guard lost 4000 lbs of coke during a bust! sure they did! I googled Tris and they have many really bad employee reviews, who say safety and quality assurance are below adequate. That is not good in the pharm business. I am going to have my meds evaluated. I swear I feel like I am being poisoned.

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I have taken Hydrocodone 10-325 for years for chronic pain. It was the yellow oblong tabs.

This time, however, I went to a different pharmacy that uses a different manufacturer.

As soon as I took the new medication, I had an anaphylactic reaction within 20 minutes.

I believe the manufacturer either has a quality control issue or the pharmacy contaminated the product.

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the generics can vary several milligrams, more or less. doesnt seem right but the regulations allow for the variances. thats why some prescriptions work and some dont. some just dont have the prescribed amount.

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This doesn't make sence. If a bottle is labeled 10mg, that is what it must have to be approved. They can't call it 10mg of hydrocodone and have it actually be 8 or 12.

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If a brand has 10 mg of an active ingredient, the generic can have 8 mg-12 mg of the active ingredient.

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Unfortunately, I suspect you are correct in your statement implying that the mallinckrodt 10/325 tablets contain less hydrocodone than other brands. They are the only brand I ever tried where there was no constipation associated with taking this medication. However, since pharmacists will INSIST all brands are the same, I choose to focus on the negative side effects of the mallinckrodt tablets. Anyway, one more reason not to use mallinckrodt, even if you have to pay out of pocket at Walgreens. Funny, everyone else takes my insurance.

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Sorry, I don't know the answer to your question... but I wanted to let you know that there are many different varieties of "white" Norco. The generic "white Norco" manufacturers I'm aware of are Amneal, Tris Pharma, and Malincrodt (sp?). None of these generic drugs have anywhere near 10MG of hydrocodone in them (usually closer to 8 MG). Unless you have little to no tolerance, they will not help with acute or chronic pain. The Qualitest generic (which is yellow) probably has between 9-10MGs, and the Watson generic (White) likely has close to 10MGs. This is because Watson is also the company that makes the brand-name drug, Norco.

Norco has gotten very difficult to find in any pharmacy besides Walgreens. (Walgreens has the white Watson Norco, but my insurance won't cover it--and it costs $95 per prescription if I go outside of my insurance network.) But if you can go to Walgreens--that would be my suggestion. CVS has Malinkrodt--you may as well take sugar pills; and all the little mom-and-pop pharmacies are hit and miss. One month they'll have Qualitest and all is well; the next month, they have Tris Pharma and I'm in complete agony all month long.

I hope this helps a little. I know it is very frustrating to realize that many generic drugs on the market do not work and that as a consumer, you have no recourse but to take these sub-standard, low-quality pills and suffer through the pain. Good luck!

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Is there a pharmacy in Los Angeles County that has hydrocodone 10-325 (yellow) manufactured by Qualitest? I can not take the white.

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When you say, "The 10 & 325 portions should be pretty equivalent between manufacturers," you are incorrect. (Sorry, but people need to understand what the FDA has done to generic drugs--and this statement is just not true.)

In fact, the active ingredients in a generic drug can vary by as much as FORTY (40) PERCENT from one generic drug to another. So if you have a headache, nausea, shakes, etc. and you have just changed to a different generic after being on the same generic for years, then you could very well be feeling withdrawal symptoms because you are now getting 40% less of the active ingredient(s) than in the past. Alternatively, you could be extremely intoxicated and cause grave harm to yourself or others should the pharmacy give you a generic with 40% MORE of the active ingredient that you are used to taking and you get behind the wheel.

This is a truly shameful policy that the FDA has put into place. My father is on blood thinners--and per his doctor, it is CRITICAL that he get the same generic every time because the huge variation from one generic to another could cause him to either bleed to death or develop a blood clot. A 40% variance between different manufacturers of the same generic drug is unbelievably dangerous, yet it is completely legal for drug companies to do this. (I actually spoke to someone at the FDA who told me all of this--I just really couldn't believe what he was telling me.)

How many lives have been lost because of this harmful and reckless generic drug policy?! How many overdoses (opiates), suicides (antidepressants), and car crashes (any one of a number of sedative or opioid drugs) will it take for them to change it?! Nope. They won't. They just point fingers at the patients and say they are "abusers". No one even TALKS about this when people overdose! But I am absolutely certain that this policy is causing opiate deaths.

This policy has caused me and my family great harm and it wasn't until last year that I learned what was really going on. You cannot trust generic drugs. But sadly, insurance will NOT pay for name brand drugs. And while doctors know all about this, they are loathe to insist on name brands because they are hassled continuously by insurance companies for doing so. And if they write a specific generic on the prescription, you will just be turned away by one pharmacy after another. They will NOT get the generic you need because it costs them too much--and the insurance companies won't reimburse them. So they buy the cheapest possible generic drugs from India. And they don't work.

The U.S. healthcare system is SO broken.

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The 10 & 325 portions should be pretty equivalent between manufacturers. The inactive portions are quite different. The solubilities of Qualitest and Mallinckrodt are very different. The Malli's dissolve rapidly in hot water, the Quali's take time to dissolve. The absorption rates are therefore different. THEY ARE NOT THE SAME...and the pharmacist treats you like a KooK if you say they are different. I got stuck with Malli's this time. Never again, keep trying & you will find a pharmacy that carries Qualitest or Amneal. The problem with the Mallinckrodt pills is that they give me VERY BAD HEADACHES & make me VERY DIZZY. Sure they relieve pain but you end up with 2 very unpleasant side effects.

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Yes, far too many people do repeat that same stuff, without knowing the facts.

For anyone interested, the details can be found under the Hatch-Waxman Act of 1984.

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