How Long Does Linzess Stay In Your System (Top voted first)

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How long does it take for Linzess to be completely out of your system?

49 Replies (3 Pages)

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2

How long does it take on average for Linzess to get out of the body?

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Re: Cathy (# 3) Expand Referenced Message

Very dangerous drug. Just got off. I wouldn't be surprised if there's a cover up of this drug.

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Re: NinaBaker (# 11) Expand Referenced Message

I've been on linzess for about 3 to 4 weeks now and I've had this happening to me also, so I stopped taking it but I'm still getting the pass out feeling with lightheadedness and dizziness. Was in the ER for it last night. Pretty scary. How long until that went away for you after u quit taking it?

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Top Answer
From what I could gather, Linaclotide (Linzess) doesn't remain in your system very long at all. According to a study on NIH.gov, the parent drug (Linaclotide) completely degrades to its metabolite within 30 minutes, with a first-order half-life of only 3 minutes.

[1] source: PubMed / PMC3638410

That said, my understanding is that Linzess should be completely out of one's system within 1-3 days easy. However there are other important variables outside of the half life that may prolong or otherwise have some sort of impact on the estimated time frame.

Hope this helps!
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10

How long does it take for Linzess to leave your system?

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7

I'm having cold like symptoms after taking Linzess, how long will these symptoms continue? They are quite annoying.

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Re: Jesse (# 13) Expand Referenced Message

I have had heart palpitations for 2months since stopping Linzess. I now see a heart doctor as I can't sleep and have dizzy spells regularly. This medicine is evil and causes this problem in 100% of women, 50% of African Americans and 33% people between 50-59. I fall in all categories and don't know when I will recover.

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Re: Barbara (# 7) Expand Referenced Message

I am feeling the same way after taking Linzess... I have a headache, dizziness, diarrhea, and am feeling cold.

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18

How long does it take for linzess to leave your system before beginning another med?

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4

Re: David (# 1) Expand Referenced Message

Thank you David. I am very worried. My Grandson has had chronic constipation since birth. Dr's tell us to give him mirilax, did. Didn't do any miracles but helped. Now that he's 16 he refuses to take the powder, it's gritty and he says tastes awful. Anyway, my concern now is for 4-3 days he hasn't went, he's very tired, nauseous, been sent home 2 days in a row this week because of feeling tired and feeling bad and nauseous. So I gave him one 145 mcg Linzess capsule tonight at about 8:59pm. He kept trying go before and no go. So I thought the bottle said, do not give to children under age 6. It did. So I gave him one. Then went to read how long before it may work, and read 'don't give to children under 6 at all, or between 6-18 years of age'. I am now freaking out. Please let me know if you think 1 pill will hurt him. As you can see I can not sleep. Appreciate any advice.

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I have been off of Linzess now for 3 weeks because of bad rectal bleeding! The effects of this drug still has not gone away (severe gas and bloating with very soft stool oozing -- this has been a mess! Never experienced this before the Linzess! I have now had to start to use the very strong anti-diarrhea to try and stop this mess)!

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Re: Pat (# 8) Expand Referenced Message

Same I took 75mg yesterday and I have a headache stomach pains etc. unfortunately this is the only medication that lets me go. But the side effects I get cold shaky I feel like I’m going to pass out I get extremely dizzy I hope I can find something else that works and doesn’t cause so much discomfort.

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16

I also was on the 72... I only took for a week, my symptoms worsened, and even started with bad headaches. Been off for two days and still have headaches.

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17

How long does it stay in your system and does it clean out your system?

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27

I took my 1st pill and within an hour i started feeling uneasy. By time the next 15 minutes was in the bathroom with severe diarrhea. Was not fun at all. I was prescribed Linzess because of IBS and Constipation all the time. Well it caused me to get a horrible headache with face numbness and heavy arm. Went to hospital and was given meds to try to stop the headache/migraine it triggered (was one of the worst, head felt like it could explode). Also some swelling in throat. The next days still had headache but not as bad. Also lots of lightheaded and dizziness with weakness in arms. I asked dr how long before med will be out. He tried telling me it should already be out of my system since it was a gut med. That didn't sound right. But i did add Linzess to my continuously growing med allergy list.

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Re: NinaBaker (# 11) Expand Referenced Message

Drink SMARTWATER at least 2 cups. It has the correct balance of potassium and sodium.

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Re: NinaBaker (# 11) Expand Referenced Message

I like Dulcolax much better. I take 2 at 3:30 AM, and I go at 9 AM. It is more predictable, and not as harsh as Linzess. I thought I was going to die when on the Linzess. It made me dizzy, and had explosive diarrhea and bad cramps. Never again.

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Re: Kitty (# 4) Expand Referenced Message

I'm very sorry to hear about your grandson. I hope he's gotten around to feeling better since the timing of your post. Unfortunately, since there's no way of knowing ahead of time how anyone will react/respond to pharmaceutical medications, all I can do is encourage him to consult with a doctor when it comes to prescription drugs such as Linzess... However, I don't know if you heard of Essiac tea leaf, but it works miracles for me and my family whenever serious indigestion occurs, so I just thought I'd mention it as another possible avenue of treatment. I'm actually very hesitant to take it unless the problem is severe because it works almost too well. All you need is an 8oz cup full and it seriously cleans you out like nobody's business, LOL! I believe it is readily available at most health food stores as well as Amazon and other internet retailers. Please let me know if I could be of any more assistance in this matter.

Wishing you both good health always!

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Re: Diane (# 9) Expand Referenced Message

Please, pretty please, explain!

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Re: B (# 16) Expand Referenced Message

My symptoms worsened as well! I have had a constant headaches too, but I am prone to them. It hasn't helped me, I just have gone 3x in 10 days and only hard balls.

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