Drinking Coffee With Linzess

I have been taken my linzess 290 mcg with coffee every day and then I continue to drink my full cup of coffee. My question is can that hurt me? I just read I should take this med with a full glass of water. Have I cause any damage by taking this med with warm coffee? Maybe that's why It has not been working and I am feeling some abdominal pain. thank you for replying back.

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Hello Tawanna,

When taking any medication it is best to administer the medication as it is instructed.

Linzess is a medication used to treat constipation and irritable bowel syndrome. According to the NIH this medication contains the active ingredient linaclotide (NDC 0456-1202) which lists Diarrhea, Abdominal pain, Flatulence and Abdominal distension as common side effects. It is instructed to have this medication taken on an empty stomach with a glass of water but I have seen other discussions where doctors have instructed their patients to administer this medication with coffee or even sometimes a fatty breakfast. I would discuss your concerns with your doctor and see if it's ok for you to continue administering the medication with coffee, in the meantime I would administer the medication as instructed.

As a general note there are a number of reasons that taking your medication with coffee might adversely affect it's ability to function properly. Coffee contains tannic acid which can have an adverse reaction with your medication potentially reducing it's effectiveness as well as assist your stomach acid in dissolving the coating faster resulting in less efficiency. Another downside is that coffee contains caffeine which will increase your metabolism, which can increase the rate which your body absorbs and processes the contents of your medication or possibly even have the medication pass right through the system.

I hope this information helps.

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