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Does Eliquis Cause Insomnia (Page 2) (Top voted first)

Updated October 19, 2025
Charlie Says:
Tue, February 2, 2016

I started taking Eliquis a few weeks ago, my biggest complaint is insomnia! Anyone else have the same problem and if you did, what did you do, what did you take to fall asleep? I've tried Tylenol PM - seem to have to take 2-3 to fall asleep. My doctor suggested Melatonin, I bought the 10mg, that didn't work either... Any suggestions?

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Verwon Says:
Fri, February 19, 2016

Hello, Charlie! How are you? I'm sorry about the problem you're having. Has there been any improvement, yet?

Most side effects are transient and will go away in time, once your body gets used to a medication, but that can take 4 to 5 weeks.

As reported by MedlinePlus, other typical side effects for Eliquis may include nausea, headache, trouble breathing, increased risk of bleeding and easy bruising. [1]

Have you tried avoiding caffeine and other stimulants in the evening, including sugary foods?

You may want to speak to your doctor, again, and ask about trying a low dose insomnia medication, for awhile, such as Ambien.

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