Dangerous Combination: Neurontin And Opiates (Page 2) (Top voted first)

One of the contraindications while taking Neurontin is using opiates such as Hydrocodone (Vicodin) and Oyxcodone (Percocet). The opiates potentiate the effect of Neurotin by 14%. With Morphine, it increases the effect of Neurotin by 44%.

My husband was on Neurontin at 900 mg a day (taken in three doses). At that time, he was not taking much of his pain killer, Oxycodone (Percocet), maybe one 5mg dose a night. My husband was originally took Neurotin for shingles nerve pain.

His doctor decided to increase his dose of Neurontin to 1800 mg per day (three equal doses). Before that time, my husband increased his Oxycodone to two 5mg tablets before bedtime and another 5mg tablet about four hours later.

Upon the increase in Neurontin, my husband started to experience some adverse effects. These included:
Mental Confusion
Severe drowsiness
Dizziness
Lack of coordination
Numbness in toes
Swelling in feet
Belligerent
Hostility
Argumentative
Mood Swings
Rapid speech, slurred speech

He could not hold a sane conversation with me, keep track of time, walk without running into things, remember what someone had just said, interact with others without hostility and being argumentative, keep awake during the daytime, and could not speak and be understood.

The symptoms escalated from minor to major in a matter of days. It necessitated medical intervention, however, due to my husband's belligerent and confused state he refused to go to the ER. He did not want to spend the money.

My husband has a mental disorder. Caution is advised in giving patients Neurotin who have mental disorders. His disorder is a personality disorder, Obsessive Compulsive Personality Disorder ( *not* Obsessive Compulsive Disorder ), which has some of the exact symptoms as Neurontin’s side effects. What transpired over two weeks, my husband’s personality disorder escalated into a monster. His behaviors were off the chart. Those symptoms from the list above are Belligerent, Hostility, Argumentative, Mood Swings, Rapid Speech.

His speech was so distorted, rapid and slurred, that the medical assistant who spoke to him on the phone was alarmed. Based on his distorted speech, the doctor decided he should go to the ER instead of seeing her.

After he essentially refused to go to the ER, my husband decided to reduce his dose of Neurontin and Percocet. Now he is going through withdrawals. I told him he should decrease it slower. However, he insists upon doing it his way, a behavior of OCPD. He went cold turkey on the Percocet, taking none now. In one day, he decreased the Neurontin from 1800mg to 900mg.

On my husband’s side is my background in nursing with a speciality in pharmacology. I started to read up on Neurotin on drug.com and the rxlist.com . I discovered that Neurontin’s effects are potentiated by Hydrocodone (Vicodin). Upon further reading, I found Oxycodone (Percocet) is a related to Hydrocodone and therefore would do the same thing.

REPLY

REPORT

For the people who don't know gabby's and Subutex or Suboxone go GREAT together!!! The whole key is to find (YOUR) right dose. I've found if I take just the right amount I actually get energy and become very talkative and feel great! But if I take to much I get all fumbly bumbly drop stuff and my hands don't work the way I want them to. Or I can get really tired so there is a magic number you just have to find it! I'm lucky I had a friend that always filled his gabby 300mg's and never took them for a year. Before he left town he gave them to me so I was able to figure out what my perfect number was. I usually take(mine are all 300mg) 3 in the morning 3 at around 11 3 at 2ish 3 at 5p.m. That's my daily routine with about a half of a subutex. Some days I take a little more some days less. I wish I could just get prescribed Adderall that would be great for energy and focus. Guess I'll keep on wishing hope this helped or if anyone has anything they want to add or suggest please do

REPLY

Was this helpful? 0

That's why u should always use the same Dr and pharmacy.

REPLY

Was this helpful? 0

Where do you get your information?? To say that "anything over 200 mg is 'whoopass'", as you put it--is completely ridiculous! Are you even thinking of the right drug? 800-2400 MG's a day is pretty much standard with this drug. It's near impossible to OD on because a normal working body just pisses out what's not needed just like vitamin C. I think you're either extremely low tolerant, like off the charts low tolerant to safe, relatively harmless drugs...or just a huge melodramatic drama Queen.

REPLY

Was this helpful? 0

So I am really wondering if this can work to get off opiates. I am currently on methadone and when I took 1 capsule( sorry don't know mg.) Within 20 minutes,I felt as if I was in straight up withdrawals.(nausea,vomiting,dizzy,sweats,chills etc) I'm wondering if the methadone and GABA had a reaction? Although I had not had my methadone in about 6hours approximately.It was awful and idk if I should try to take it again bc I just pulled a muscle in my back today and don't know if I should try it again. Bc I am in horrible pain at this moment.Any ideas?

REPLY

Was this helpful? 0

I have been taking Gabapentin with low-dose Hydrocodone (5-35) for about 5 years for moderate to severe chronic pain associated with spinal stenosis, sciatica, and fibromyalgia. Before starting on this I had tried many other options, including Cymbalta, various SNR's, Tramidol, Lyrica, Sevella, and a few others I don't remember. I am currently taking 600mg Gabapentin 3x a day (1800 mg/day), having ramped up from 900/day a year ago. I take Hydro as needed - perhaps 3-4/week.

In my experience, the Gabapentin greatly increases the pain killing effect of the Hydro, or even a simple Ibuprofen. I tolerate the drug very well - in fact, it's one of the least problematic drugs I've ever taken. .

My doc would like me to cut back further on the opiates and ramp up to as much as 1200mg 3x/day (3600mg/day) of Gabapentin.

My questions are - 1) has anyone else had good results of a Gaba/Hydro combination, and 2) anyone else taking 3600mg/day Gaba?

REPLY

Was this helpful? 0

I recently started cutting back on my Gabbapentin intake. I was taking anywhere from 2,000 to 5,000mg a day sometimes mixing it with subutex or suboxone. And sometimes mixing it with oxycodone and oxymorphone. I'd take less gabby's when on the oxy. Now I'm taking anywhere between 900-1,800mg respectively. I noticed 2 days ago my feet and ankles were getting swollen and as of today they hurt to the touch and putting on my socks. I'm going to try and elevate them for awhile and see if that helps. If not I'll try and an soak them in warm Epsom salt. I'm starting to get nervous cause I'm in a lot of pain even with 90mg of oxymorphone ER. Does anyone have any suggestions on what the cause is and maybe something else I can do or try to make the swelling go down or away? And when do I say screw it and go to the ER? I'm a 39yr old single white male, six foot 2, 190lbs. Any and all help is appreciated.

REPLY

Was this helpful? 0

Okay, so I've been taking percocet for chronic pain for at least 4 years and it has help but now I came to realized I need to take at least 10mg in the morning to be able to function and start my day, if I don't take I have to push myself to even get out of bed, lately the pain is not going away and my dr prescribed gabapentin and I am hesitant to take it for fear of not being able to get the push that Percocet gives me, so my question is; would gabapentin will block the feeling Percocet gives me? I appreciate Simple answers, I have read all of the above and I am very confused of the contradictions of the many answers. I just want to know if taking gabapentin would take away the help Percocet gives me to función in a normal (my normal) way. Thank you in advance.

REPLY

Was this helpful? 0

The article refers mostly to Neurontin's effect on pregnant women.

REPLY

Was this helpful? 0

I looked on line to see if anyone else experienced the same effects as me. I am on a relatively low dose of neurontin 200 mg every 8 hours and 20 mg OxyContin ER post spinal fusion. Also 5 mg oxycodone q4hours pen. When they are taken together it totally incapacitates me for at least an hour to two hours. I just feel totally drugged and just lay in bed until it passes. Is this normal?? I am so drowsy, lightheaded, speech is slurred, blurred vision etc.

REPLY

Was this helpful? 2

My fiance had a back injury on a construction site and ended up having the back surgeries. He is also a type one diabetic. Well the doctors have him Percocet, oxycontin, morphine, and tizanidine. He is still in lots of pain and I keep telling him the doctors have him on the wrong mixture of meds. He was in the hospital for chest pains, they said his chest is fine. I'm just concerned with his cocktail of meds and he is anxious to return to work but is in lots of pain that is much worse at night.

REPLY

Was this helpful? 0

I am a 25 year old woman and was prescribed neurontin today for pain for auto amune disease, 800mg a day, before I was taking oxycodone and this pain medicine was working just fine by its self. this combination was giving to me by a pa-c because my doctor was not in to refill my pain medicine. I am scared to take this medicine. Im already allergic to so many medication penicillin, tramodol, codeine, shell fish, and latex. Could someone please shed light on if this something I should take, Or go back to my regular MD and let her know while she was out of the office the pa-c which by medication and now I'M scared to take it Especially having two young children I drive to school everyday? Please all opinions welcome Thank you

REPLY

Was this helpful? 0

I'm so sorry for what you're going through.. I had a drunk driver crash my car of course he totaled it..my neck was broken 4 surgerys on left arm,two on right shoulder.. I am still taking oxcycodone 30 per day.all prescribed by a very good P.M. Doctor.. He's been giving me nerve blocks for the lumbar L4L5 and it's really helping.. My Primary, who has allllll of the meds I'm taking.. I don't want to go through what sad and horrible stories I've read.. This is what I did when the primary tried to add Gabapenton..I Googled it and showed him the possible side affects. And showed him..he said I've never had that happen, but thanks for telling me.. Now I'll be certain NOT to mix any opiates with Gabapenton.
I'm in no way being critical,, but please if your able,, Google every pill that goes in your body,,Have your Pharmacist look up interactions..I don't want to read about another death from these pills and the deafly interactions..
Pleeeeez ask anyone in health care just to be safe..
Prayers for everyone. J

REPLY

Was this helpful? 0

Your post makes no sense. It gives off the feeling that you are either high or drunk...

REPLY

Was this helpful? 0

My husband, a diabetic in stage 4 renal, was prescribed morphine and vicoden for neuropothy. His healthcare provider prescribed gabapentin in addition to the two aforementioned drugs. Within two weeks of taking the gabapentin, he lapsed into a coma on May 16, 2014 and died on June 4th. Never regaining consciousness. Admitting doctor told me because the kidneys could not flush drugs quickly enough, they believe it was like an overdose. I still can't understand why a NP is allowed to prescribed so much narcotic!

REPLY

Was this helpful? 6

I've been on gabapentine got urs fonts not help much I have to see rhumotholy in been in a and full aff accident s that I even have panic attacks when I get in a vehicle not I can't sit stand n sever pain on my neck what to do

REPLY

Was this helpful? 0

i an a patient of veinous anomaly and had a focal seizure in december 2009 till then i have been given oxetol 300mg and ...

2 REPLIES

My dr. put me on lexamil 20mg a day for a month with alzam 0.5mg (3 x a day). No refill prescription. I have 6 lexamil p...

1 REPLY

is it good for control diabatis 2and wt is the side affect i had continue head ache ## can we take continuously Glycomet...

3 REPLIES

I have found recently information on the net about the harmful effects of evening primrose oil when taken with stelazine...

Can I take Glovit-Cal and Absolut 3G tablets daily or should I instead take Supradyn? The first 2 do not have Vitamin A....

2 REPLIES

i want to know method of estimation of doxophylline and montelukast in a dosage form. ## What is the brand name of Doxop...

4 REPLIES

Chymoral AP has Trypsin Chymotrypsin which should be taken before meals and Aceclofenac and Paracetamol which should be ...

1 REPLY

My BP is always around 120/80 and 130/80 when i used to take Stamlobeta for the past 30 years. Ever since my physician c...

2 REPLIES

Are there studies that evidence the advantage of the combination of an Analgesic and a Diuretic? Was this combination ap...

1 REPLY

Can 'combination-3' and 'ferrous fumarate' sugar coated tablets correct irregular menstruation or boost ...

2 REPLIES