Can Percocet And Flexeril Be Taken Together? (Top voted first)

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I take Percocet and Flexeril and was told by the doctor to wait a couple of hours before I take one or the other. What are the possible side effects, positive and negative?

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9

As pharmacist (PharmD), let me answer the question and also explain why I see some "red flags" in this thread.

First, cyclobenzaprine and Percocets can be taken together... with caution. The combination can cause CNS depression (slowed heart rate, decreased respiratory rate, sedation), however they both work via different mechanisms which makes this combination not as concerning to me as others. I would recommend trying to space them out by a few hours, and if a person had been on the Percocets or other opioid pain medications prior, I'd be even less concerned about taking them together due to opioid tolerance. This combination is something I see quite frequently prescribed by doctors..especially in situations of back and neck pain.

Second, to end this debate. There are many red flags about these "cocktails". Xanax, Klonopin, and Restoril are all benzodiazepines--- no doctor would prescribe all THREE to be taken TOGETHER at the same time...they all work the same mechanistically at the GABA receptor, it is just their chemistry causes them to metabolize differently and have different durations or capabilities of penetrating the blood brain barrier. There is absolutely no medical reason-- the patient would be completely knocked out. Maybe Klonopin OR Xanax in the am, and Restoril at bedtime... but not together.
The other red flag is that all the pain killers are short acting (roxicodone and dilaudid). If a person is in chronic pain (which it sounds like), the standard treatment is a long acting pain killer (8-12-24 hours duration) and then a short acting opioid for break-through pain.
The End.

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3

Chris420 sounds like a crackhead and you should not listen to him and you should never mix any of the drugs he listed without a doctor's explicit instructions. Get instructions from your doctor, not an RN. At least call your local pharmacy and ask the pharmacist whether anything you take is contraindicated with anything else you need to take. Chris420 if you really are an RN, which I doubt, you should be fired.

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5

OMG!!! I'm a real ARNP and my professional medical opinion is that Chris420 is insane for taking all those things together. I would hate to have my life in his hands. You are a disgrace for all medical professionals out there. If your dr ok's it you may take a 10mg flexeril and a 5/325 Percocet. One is a muscle relaxer and one is a pain killer. If he advised you otherwise he/she knows your case and knows why they did it. Follow your dr's instructions is my opinion. DO NOT listen to that fool

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8

Chris & Stud are right! Gosh! My doctor prescribes me percocet 10/325 and flexeril 10 at the same time. And for Chris to be prescribed all of those, who are you to judge? Jerks... This is why we have "bully" issues! Apparently, it is OK to take whatever a person takes. I have 12 pills I take a day. Including zanaflex, flexeril, percocet, neurottin, xanax, trazadone and many others. And that's my "cocktail" I call it. Lol lighten up guys. No one here is dead. And NOONE here is a DOCTOR. So unless you can prove it, you could be a 12 year old kid just messing with people or a 80 year old perv who likes getting his/her rocks off by messing with peoples heads and feelings. Being a bully is not the answer. Backpainhelp, I really feel sorry for your loved ones. Calling people crackhead? Mama always said "it takes one to know one". I really can't believe, whatever ages you are, that you would stoop so low. I really hope you mean ones do not have children. My boys are polite, caring, mature, respectful and responsible SIX YEAR OLDS!! its sad when a child is more compassionate and friendly than their elders. Wow, if I were a parent to a rude little jerk, I would be ashamed, embarrassed and shocked. We know what we know and we are on sites like this one, to help people. NOT to bash what others say and make ourselves feel higher and mightier. Because obviously, you're compensating for the lack of in your real day to day life.

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4

LOL! WTF? Please don't take those things together.

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13

Yes I did, LAST YEAR when I posted this. It was midnight when I posted my question and was in a lot of pain; was hoping someone could offer some advice. So relaaaaaaax.

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1

More than likely he advise to space them apart because they can both cause central nervous system depression. This can cause your breathing to slow and be shallower, a slower heart rate and etc.

Using them both together can also worsen some other side effects, that they both can cause, such as drowsiness, dizziness and nausea.

He is probably trying to minimize this for you.

If you use them as he instructed you to, you may be able to get better pain control. Many doctors prescribe a muscle relaxant, like Flexeril, along with other pain management medications. Reducing the tenseness in the muscles can help lessen the amount of pain a person is suffering from.

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12

Why are you consulting a website? You have no idea who you are getting advice from! ASK YOUR DOCTOR! HE is the one who prescribed the meds!

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Please remember that medications like Flexeril and Percocet, or any other CNS depressant can be deadly. Central Nervous System Depressants are a serious matter. Mixing more than two at a time can cause major breathing issues as well. If you must take more than one CNS depressant, please follow the directions that your doctor ordered. Also, if you have more than one doctor make sure that all your doctors know how many CNS depressants you are taking. Good luck with all that you do and if you ever feel like you are dependent on these medications, ask for help.

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18

I take Percocet, klonapin (sp), ambien,prevastatin, synthroid, clonazapam,2blood pressure meds and flexeril as needed...have for .years. I'm 66 and doing my part building a home. I'm hurting right now but I've worked 2&3 jobs my my whole life. I want to live until I die, if you get my drift. No, the RN is not a druggie. She is working for a living, not living off society. Do what it takes, muscle through the pain thats left after you take your prescribed meds. Dont judge others till you've walked or worked in their shoes. If you cut a few years of your life you will never know. I know a lot more old drunks than I do old doctors.

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Hello Dr. Jenn, my names is Basille. I like how you broke down your thorough explanation of meds and how they metabolize differently in a person's body. However, the reason I am reaching out to you is because I have some serious medical conditions myself and would like to speak to you and have a more detailed discussion with you pertaining to my chronic pain. I am only 23 yrs old from Philadelphia, and have been suffering from on going pain for over 5 yrs now. I would appreciate if you have the time to reach back with me and I look forward to it, Thank you and I appreciate it. Good day

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Chris 420 is 100% right are you an RN I am and we give prescriptions ALL DAY LONG!!! It's okay to take them together. I would suggest spacing them but for people I give it to in the hospital I crush up all kinds of crap in their pudding (hydrocodone, muscle relaxers, breakthrough medicine like ultram) AND GUESS WHAT EVERYONE AND I MEAN EVERYONE LIVES HONESTLY get an education....

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7

Can I take 1 percoset and one 100 mg trazadone within 2 hours of each other? Been taking trazadone for over a year, prescribed percoset today for pinched nerve and osteoarthritis. Thanks for any help!

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14

what can happen if i drink 2 lite beers and feel high?

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15

I'm curious... How are you able to keep up with a nursing job on those medications? Even with tolerance don't they make it difficult for you to concentrate and keep up with the pace of your work? I used to need these medications also but not even half of what you listed and was unable to keep working at a similar type job. I certainly tried but kept getting let go. How do you do it?

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25

So how is the percoset today going for you? Has it turned into pure oxycodone 30mg's & a couple oxycotins er's? I only ask this because so very many people end up in the boat I'm writing about, though their injuries are more severe but you haven't told us of your injuries in any detail. I fell from near three stories & I landed on my back & neck, I cannot recall much but the fall & all else is blank until I awoke in the ER ( ICU ) dept. & had over what seemed like a dozen dr's around me running around & they had already cut all my clothes off, it was very frightening & I honestly along with many others am surprised I'm still even alive, ( I often wish I had of passed no I'm not suicidal it's just the injuries I was left with are beyond repAir & my life will never be the same ) I only know of the fall in details due to the other people who were there and around me to witness the fall, it would have killed the average person but being at the time I was around 175-180 and was in great shape & was use to severe slams & falls, and the like due to sports & my love for martial arts, to this day I'm now very depressed at where I'm at & I honestly feel that I could just pass at times, I had no insurance & that was a few years ago so needless to say my life savings ( I was only 36 at the time of the fall ) is all used up & the doctors have all my monies them & the pharmacists & drug companies. Sorry to ramble it's just that I wonder how you are today & if you still on the meds.?

I refuse to take the medications that the dr's want me on & trust me there are days I wish I was on harder meds., but a basic 15mg oxycodone 3x's daily with flexeril twice daily & lots of gabapentin is all I will take & I hate to take those, I use to be like a athletic machine, I cycled over 30-40+ miles 3-4 times a week, surfed & traveled to amazing destinations & was an avid Brazilian jiu jitsu black belt, along with my desire & love to sky dive, snorkel depths to the most extreme, but now I'm approaching 40 yrs old & I'm broke, have no insurance, have no monies, cannot work or get on Medicare or Medicaid (f*** florida this state is for people that come here (wealthy) to die & they don't care of those in need of help, I could go on all day but I just want to explain that most start on these medications & are often up to amazing amounts of drugs, I know of people that are only 10% hurt like myself & they are on all kinds of pain meds & I know they don't need them, I'm just venting & I apologize but in this country where everyone in my family has fought for in each war known to America & I too have given my life for, we are only treated like s*** & they care not for us anymore once they are done with us. I have no family just lost my last living uncle & my brother as well, so though all this is a very sad story I still try & maintain a good & stable piece of mind, I often wonder why god has out me in this path & I'm at the point of my back where it's beginning to degenerate badly & I've lost one knee ( blown out ) due to my back not being able to hold me up & I still refuse the hard meds.,

I'm on pain meds for what a person with a broken arm should be on, I'm blessed as I do have a family doctor that's an amazing man he's also a specialist in many other areas of medicine but he has been my best of both a doctor & friend & wants so very much to help me even more & to see me in not so much pain but understands & I believe respects that I don't accept or take the meds I should truly be on, in this state they treat you like a junkie even on the Lil meds I take & it's often very hard to fill my meds due to all the street junkies & the black market of so much pills, it's sad & makes me angry so again with what others recommend I do suggest as well to finding a good pharmacy & sticking with them, & once they get to know you & understand your situation you have another positive source & my pharmacist is a great guy & he too has had severe back issues & surgeries, they respect that I don't take more meds than I do, s*** I have enough issue than to be strung out on all kinds of meds., but trust me I wish on days like now that I had at least a bottle of back up medications that would take care of this intense pain & issues like my arm is currently in major pain & the spasms are starting so I'm going to go, just want to say stay off the heavy narcotics & too all you street dope heads I wish you to spend just one day in mine & many others shoes, your making it very hard on us to get the needed help & respect we need to be taken care of, any ideas from anyone would be of great help as my well is dry & If it were not for a few folks I consider family I would have no help & even they are beginning to not be able to help any longer, so I have no idea where ill be in a couple months, I wish society had more understanding for those in cases like mine & even worse to be able to choose to live a life of pain & suffering or to be able to choose to go out peacefully & not have to live in constant pain, but we have more compassion for our dogs & cats in this time we live in & these animals are often put to rest so they don't have to suffer anymore.

I just wish that man will someday see this for his fellow brothers & sisters as we are born & also we must die, I don't wish to die but I cannot get any help from a industry where many are abusing the help they get. I know a lady my age that gets medical help, money, housed, etc.. & she doesn't even need it, she is constantly on vacations & cruises & it MAKES ME VERY MAD & sick, but it's the world we live in & I know I must somehow keep my faith & stand strong. If I didn't have & often plea to keep this mentality I would likely be in a nut house, I just wish I could get some help from the industry I paid into for so many years. I have worked since a little boy & I have paid into the companies that cannot even help me, being my age & a man is not to ones advantage. I think we're in the times that are near the end for man & I'm not getting religious on anyone, were all treated like sheep from the governments & the world revolves around big business, lies, greed & the foolish nature of man, I hope that I don't end up loosing my ability to walk & pray for all that need the help & speak for those that do but cannot write of it, TODAY I SAY A PRAYER FOR MANKIND & wish that man will turn from it's ways & that we will see & believe in miracles once again & that compassion for ones fellow man will over ride all this evil I see in man today, sorry to ramble, just one of those days I'm in much pain & yet no help or any meds to help me once your on the little bit of meds I'm on, they may help for an hour or two if your lucky, best of wishes to all & to all you pill heads just please get off the legit pain meds, & get a life & trust me one of pain & suffering to where you do not need these meds is not where you want to be, or six feet under because you wanted to try & feel high off a few pills, I wish you all the best, (damn I sound & feel like a 80 year old man, god please never let me loose faith!) GOOD Luck to you all! I would say god bless but I know that seems to bother & upset so many anymore these days, it's like a bad dream, but it's reality. Peace

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27

WTF? How many DR. FEELGOODS are writing for this crap. And what are the indications for truly irrational Exactly what does "much more mean?" I could not see a medical professional remaining functional on all these depressant drugs, even with tolerance, I think. I'm a shrink with a PhD in Pharmacology and your pupils alone would tell me you were soaked with opioids. In 25 years of practice, I've never had any of my scripts questioned (except for accuracy and with new patients and that's a RPh's JOB; it's an inquiry or verification, not an investigation) in 25 years. If I wrote for those drugs join those quantities for ONE patient, I might skate the first month, but by the second script, I'd get a visit from the DEA and my state Controlled Substance investigators. I can't even i gain making up Dxs that justify this crap. You are in no position to provide ANY patient care. If you're an RN, tell me what the generic name for Ultram is, why it's an OPIOID not an OPIATE and what properties does it have in common with PROZAC?

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21

I do not think Chris should be advising how to take pain meds......................this is not correct. I agree with Verwon............check with your prescribing dr. if you are seriously concerned.

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26

Excellent response. ...just saying!

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31

I'd be reluctant to prescribe both together — no, make that I never have and never will write for both of these meds for the same patient! Flexeril is related to the tricyclic antidepressants (Elavil, Tofranil) and they cause their share of dizziness and lack of coordination.... and Percocet is Oxycodone and APAP. What kind of pain do you have that Percocet alone can't quell (in the proper dose)? No need for piling one drug atop the other. If this is an "easy way" for the doc to keep the Percocet to 5/300, (by adding Flexeril to potentiate it) it's bad medicine.

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