Can Percocet And Flexeril Be Taken Together? (Page 3)
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I take Percocet and Flexeril and was told by the doctor to wait a couple of hours before I take one or the other. What are the possible side effects, positive and negative?

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As pharmacist (PharmD), let me answer the question and also explain why I see some "red flags" in this thread.

First, cyclobenzaprine and Percocets can be taken together... with caution. The combination can cause CNS depression (slowed heart rate, decreased respiratory rate, sedation), however they both work via different mechanisms which makes this combination not as concerning to me as others. I would recommend trying to space them out by a few hours, and if a person had been on the Percocets or other opioid pain medications prior, I'd be even less concerned about taking them together due to opioid tolerance. This combination is something I see quite frequently prescribed by doctors..especially in situations of back and neck pain.

Second, to end this debate. There are many red flags about these "cocktails". Xanax, Klonopin, and Restoril are all benzodiazepines--- no doctor would prescribe all THREE to be taken TOGETHER at the same time...they all work the same mechanistically at the GABA receptor, it is just their chemistry causes them to metabolize differently and have different durations or capabilities of penetrating the blood brain barrier. There is absolutely no medical reason-- the patient would be completely knocked out. Maybe Klonopin OR Xanax in the am, and Restoril at bedtime... but not together.
The other red flag is that all the pain killers are short acting (roxicodone and dilaudid). If a person is in chronic pain (which it sounds like), the standard treatment is a long acting pain killer (8-12-24 hours duration) and then a short acting opioid for break-through pain.
The End.

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Chris & Stud are right! Gosh! My doctor prescribes me percocet 10/325 and flexeril 10 at the same time. And for Chris to be prescribed all of those, who are you to judge? Jerks... This is why we have "bully" issues! Apparently, it is OK to take whatever a person takes. I have 12 pills I take a day. Including zanaflex, flexeril, percocet, neurottin, xanax, trazadone and many others. And that's my "cocktail" I call it. Lol lighten up guys. No one here is dead. And NOONE here is a DOCTOR. So unless you can prove it, you could be a 12 year old kid just messing with people or a 80 year old perv who likes getting his/her rocks off by messing with peoples heads and feelings. Being a bully is not the answer. Backpainhelp, I really feel sorry for your loved ones. Calling people crackhead? Mama always said "it takes one to know one". I really can't believe, whatever ages you are, that you would stoop so low. I really hope you mean ones do not have children. My boys are polite, caring, mature, respectful and responsible SIX YEAR OLDS!! its sad when a child is more compassionate and friendly than their elders. Wow, if I were a parent to a rude little jerk, I would be ashamed, embarrassed and shocked. We know what we know and we are on sites like this one, to help people. NOT to bash what others say and make ourselves feel higher and mightier. Because obviously, you're compensating for the lack of in your real day to day life.

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Can I take 1 percoset and one 100 mg trazadone within 2 hours of each other? Been taking trazadone for over a year, prescribed percoset today for pinched nerve and osteoarthritis. Thanks for any help!

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Chris 420 is 100% right are you an RN I am and we give prescriptions ALL DAY LONG!!! It's okay to take them together. I would suggest spacing them but for people I give it to in the hospital I crush up all kinds of crap in their pudding (hydrocodone, muscle relaxers, breakthrough medicine like ultram) AND GUESS WHAT EVERYONE AND I MEAN EVERYONE LIVES HONESTLY get an education....

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OMG!!! I'm a real ARNP and my professional medical opinion is that Chris420 is insane for taking all those things together. I would hate to have my life in his hands. You are a disgrace for all medical professionals out there. If your dr ok's it you may take a 10mg flexeril and a 5/325 Percocet. One is a muscle relaxer and one is a pain killer. If he advised you otherwise he/she knows your case and knows why they did it. Follow your dr's instructions is my opinion. DO NOT listen to that fool

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LOL! WTF? Please don't take those things together.

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Chris420 sounds like a crackhead and you should not listen to him and you should never mix any of the drugs he listed without a doctor's explicit instructions. Get instructions from your doctor, not an RN. At least call your local pharmacy and ask the pharmacist whether anything you take is contraindicated with anything else you need to take. Chris420 if you really are an RN, which I doubt, you should be fired.

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More than likely he advise to space them apart because they can both cause central nervous system depression. This can cause your breathing to slow and be shallower, a slower heart rate and etc.

Using them both together can also worsen some other side effects, that they both can cause, such as drowsiness, dizziness and nausea.

He is probably trying to minimize this for you.

If you use them as he instructed you to, you may be able to get better pain control. Many doctors prescribe a muscle relaxant, like Flexeril, along with other pain management medications. Reducing the tenseness in the muscles can help lessen the amount of pain a person is suffering from.

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