Bupropion Xl By Cipla Pharmaceuticals
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My pharmacy has been giving me refills of the generic bupropion for my last two refills that are manufactured by CIPLA. The pill is oblong and has the number 13 on one side and what appears to be a capital I on the other side. I do not feel that this generic is doing much for me. I have researched this manufacture they are located in India. Approximately 45% of the medications that are sold in the United States are manufactured in foreign countries. I am going to call my pharmacy to see if they can get one of the generics that were previously dispensed to me. The buyers for drugs at pharmacies look to find lower priced drugs, which I understand.

I have been taking Wellbutrin XL 150 mg three tablets daily for about eight years including the generic form. This medication helped my severe depression. I have tried many other families of antidepressant medications that did not work or caused side effects. The cost for the brand Wellbutrin XL continued to increase because of big Pharma greed (a discussion for another time). Eventually I had to go to the generic Wellbutrin because of the cost and my insurance would not pay for brand or my copay was too much.

When I could no longer work because of my Multiple Sclerosis and another incurable gene mutation condition I eventually received Medicare. I continued to take generic bupropion XL because I had no choice. Various generics of this medication have been dispensed to me for a number of years. The generics have never been a good as the brand Wellbutrin. For those of you that may not be aware a study was done that proved there was a difference between the brand and the generic. The main factor is that generic Wellbutrin XL rises quickly in your bloodstream then drops. The brand Wellbutrin rises up in your blood stream then goes down over a number of hours.

Perhaps for some people the generic form of Wellbutrin works okay for them. In generic medications different fillers are used and the percentage of the main ingredient can be less or higher on either side of the main ingredient. I know a pharmacist that explained this to me that confirmed my suspicions. I take other medications that are generic that seem to do okay. Nevertheless, I firmly believe that certain medications such as antidepressants, seizure medications to include some others should not be propped up as being a bioequivalent.

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REPORT

I have had problems each time my Buproprion Rx has been filled with Cipla. This last time, it had been years so I had completely forgotten to check which manufacturer the pharmacy had used. Within days I was feeling suicidal and getting ready to blow up my life because of the depression. Then I realized the symptoms started with my new bottle of pills and looked, sure enough it was Cipla. Whatever it is about their version, it severely amplifies my depression instead of resolving it.

I've been taking this prescription for years and have only had issues when using the Cipla generic. All other generics have worked as expected.

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Re: Eforest (# 28)

How positive are you the Cipla versions of bupropion XL are responsible for withdrawal feelings and awful side effects we all agree with and it isn’t withdrawal from changing generic manufactures ?

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Re: IMGT (# 4)

Did they go away? Does anyone know why we have these side effects.

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Re: BioEquivlaneceMyArse (# 3)

Did your bad side effects from Cipla ever go away? I could swear cipla helped lower my anxiety but messed my cognitive thinking and also eyesight up. Insane issues w processing information and reading

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Re: LOVE (# 10)

How long did you stay on cipla? Because I tried 150 XL and 300 and found myself sinking into what you describe as withdrawals.

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Y'all, somehow this kind is really good for me. I take my meds at night, as I can sleep perfectly. However, the past two nights (when I got my refill via Publix) I've been staying up kind of almost all night . But it's more to do with wanting to instead of literally unable to falll asleep.
I will
Seriously hate the never ending switching up super random times. It's ridiculous! Most the time the seitch up has negative effects - SOLCO bupropion 200 SR IS THE WORST SHT EVER. it's actually makers is impossible to pronounce long Chinese name, although the main issue is the TWO different WARNING LETTER S from the FDA about major issues in them faking the testing and using the same exact data and just changing the date ,I mean just all kinds of crazy things . It's available to read if nyone is interested in seeing a very detailed set of warning letters and SOLCO responses (the actual name is like zhuedang zou or something of that nature .

Anyway, I was stuck with the garbage and ended up asking my doctor If he couod prescribe a different form of bupropion so I could get actual medication that worked. I currently take the 300 mg xl . I have not had any issues with these so far.

Just wanted to share !

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Re: AnnieMae (# 40)

It's definitely worth investigating. You could also switch pharmacies

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Re: NotCipla (# 39)

I don't know if my Pharmacy will allow me to get that brand I'm really perplexed about this whole thing and unhappy.

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I became brave again and started on the Parr XL March 30th. It has worked wonders, I dropped 10 lbs, which was a good thing! I have lots of energy and am once again my optimistic self.

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Hi
I realize you wrote this post awhile ago but I have a question can you tell me what generics did work for you because recently when I picked up prescriptions they had no more of one of the generics I've taken which is Actavis I don't know that it's helping me at all either and now they've given me the cipla and I'm a little disturbed about it.
If anyone else wants to try and please do I'm finding myself extremely depressed and I don't like it my pills are the generic ER extended release I think it says Sr / ER

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Pharmstore - Choose a pharmacy with a certification that makes them adhere to strict legal procedures. I learned about this certification in a newsletter.

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Re: Anxious Annie (# 34)

Would you be able to share which Canadian pharmacy you got your Wellbutrin XL from? Thanks so much!

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I was recently prescribed an anti depressant. Silly me, I didn't recognize I was that bad off. I did Lexapro for 5 weeks, it did nothing except make me a non-orgasmic, non-stop eating machine. No thanks. Next was prescribed Wellbutrin XL 150mg, received Bupropion XL manufactured by Cipla out of India. Of course it didn't state that on the label, but I googled its image. In case anyone needs to know, it is white, oblong with an I on one side and a 13 on the other. The first 2 days were fine, a little central nervous system uptick, but that was to be expected. On the 3rd day, approx. 2 hours after taking, a headache developed, I felt like I needed to vomit, I couldn't think straight, zero ability to focus and loss of short term memory. I felt completely out of touch with my mind and body and was grateful, when approx. 10 hours later, all side effects subsided except the headache. I was back, I could think again! Head-ache? I can handle that! Then I crashed, like I had come down from speed and could hardly stay awake. As I work the swing shift, this was a problem as I still had 3 hours yet to go. I slept great that night and woke up feeling good, not even a headache! Took the Cipla again and 2 hours later, I had the same exact side effects except they were amplified, I could barely function! Somehow managed to get to work and had the same crash after the effects wore off, except this time, the side effects took longer to wear off. When I awoke the next day, I felt like I was hung-over, nauseated, headache, etc. That was it, I was done. Found out pharmacies love dishing out Cipla as it is so cheap and they make lots of money off it. I called CVS and demanded another brand, so they are going to give me PAR, of course on my dime. Now I'm afraid to even try the PAR, very disillusioned with the pharmaceutical greed and may choose to remain depressed than put my body through this again.

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If anyone is able to obtain name brand Wellbutrin 300 mg or the Par generic that's great. I took the Sandoz generic for years, now realize I was only getting a bit of a dose (see my previous posts). I am at peace and depression better now than in 20 yrs, getting my meds from Canada. I pay around $30 mo, ordering a 90 dy supply. That is less than I paid for name brand with insurance as it was always a higher tier level. I cannot begin to say how horrible these cheap generics are, at least for mood meds.

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Re: MyHeadHurts (# 5)

I have been taking ACTAVIS bupropion 300 XL and have been having problems with racing heartbeat, high blood pressure and nightmares. I thought they were from the VYBRIID I started recently. I had not associated those with the ACTAVIS until I started researching PAR Bupropion Xl since that is what they will be sending me. Just happened to find these are reported side effects with ACTAVIS bupropion 300 XL.

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This is a follow up to my June 2017 post. I suffered all summer after the generic for my Wellbutrin xl 300 mg. by Sandoz became unavailable. I tried 2 other generics, one made me have auditory hallucinations and the other just did nothing. At the same time Pristiq 50 mg which I also take went generic, it was terrible. I was severely depressed all summer and somewhat suicidal. I finally went out of country to get name brand Wellbutrin being made with original formula in Canada. Within 3 days of taking it I felt so much better. I then tried the Pristiq from the same pharmacy and felt even better. Finally, I filled my Cymbalta prescription through them as well. I feel the best I have in 25 years! I am a new person. I wake up every morning in a good, positive mood and am motivated to do things, instead of sleeping and not even being able to shower. Please be aware and vote against any legislation that may prohibit us from filling prescriptions from out of the country. If the US can't properly regulate these generics and allow us access to meds we need, legislators should not prohibit us from finding the quality where we can. While I resent having an RX insurance that I'm unable to use, my brain is worth the $$. P.S. generic Klonopin sucks as well, never as strong as the original name brand, have to take more to obtain the same effect.

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Re: Anne (# 11)

CIGNA home delivery has the par 300 mg, however the 150 mg is Lupin, which I believe is screwing me up. I've been taking 450 mg for sometime successfully and didn't even realize they were different manufacturers. Now I wish I'd saved all my bottles but apparently I've been taking the par for a long time because that's what the pharmacist told me on the phone. I believe that this lupin 150 is responsible for sudden suicidal thoughts and up-and-down emotions and I'll kinds of crazy things.

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Re: Anne (# 11)

I'm on the hunt as well for alternate pharmacy that might carry it.

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Generic Wellbutrin works but the initial side effects are more intense and last longer.

I'm currently on brand Wellbutrin xl 300 mg. my insurance pays $1600 for a month's supply. my copay is $50 it's worth it. i'm losing weight really fast. i've quit smoking too! i've lost 10 lbs. in 3 weeks and the only exercise i do is that i walk 50 minutes each day.

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See link below to report to the FDA. I'm a healthcare professional who also takes bupropion 150 xl. There is something seriously wrong with the Cipla generic!

MedWatch Online Voluntary Reporting Form

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