Bupropion Xl 300 By Lupin (l016)
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Has anyone tried Bupropion XL 300 by Lupin - a round pill marked L016?

Just received these from Walgreen's internet pharmacy and I'm very concerned. I started taking this medication about two years ago, the PAR generic, and everything was great. Then, CVS changed to Cipla and things got bad -- it was only thanks to rxchat that I figured out the problem was caused by the new manufacturer. So, I switched to Walgreens, which had Actavis. It was so much better for me than Cipla but not quite as good as PAR. Quite by accident, I found that when ordering from Walgreen's internet pharmacy I got the med manufactured by PAR.

All's been good for many months... until I just opened my newest prescription and found it's by a newly approved generic by Lupin. Hopefully it will be fine, but I am nervous now.

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Trust your gut, is the main message. Lupin causes me dizziness. I’ve been on Bupropion for 10 years and I can tell when I’ve been switched. I’ve never used PAR but Actavis works well for me. It can be hard to get these days. Lupin seems to be everywhere. Let’s all keep complaining to our pharmacist till they stop buying it.

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Re: Bunk Bupropion (# 9)

I agree. There is something wrong with the Lupin version of these pills.

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I’ve been having increasing brain zaps and trying to figure out why. I was recently changed over to Lupin. 300. I’m glad to see it could be the issue, though I just got a 90 day supply and have no idea how insurance or the pharmacy will deal. I just dug up some old pills in smaller doses, so I’ll take those tomorrow and see if it helps.

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I have the same problem. Par is the only one that I have found that works for me. I am super discouraged because I just got my prescription from Walgreens and the same thing as you, Lupin. I am going through a break up and I feel very insecure that I don’t have the medication that I know works for me.

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I'm so glad I found this thread. I've been on Cipla brand 300mg for 4 months. I was feeling great. Got a new Rx filled and the pills were different looking. First day I had a horrible headache. Next couple days I noticed I was very fatigued and my neck and shoulders were so tight and ached. I was falling asleep at 8pm. I'm usually up to 10 or 11pm. Constipated (which never happens). Then I was getting extremely agitated at simple problems encountered at work and at home. I called the pharmacist and explained the switch in manufacturer to Lupin was like I had just stopped taking Bupropion cold turkey. She refilled with Cipla brand and I started to feel better about 6 hrs after taking Cipla again. Thank you all for sharing your experience with the Lupin brand. It's definitely not equivalent to the Cipla brand.

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Re: mmmm123 (# 13)

I’m wondering, how can the formulations by different manufacturers be so different? Isn’t a generic supposed to closely mimic the formulation of the name brand? Maybe the various manufacturers use lower quality ingredients?

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Re: Michelle (# 20)

Wow- has cut back on PAR generic 150 xl for months, ready to go natural and stressful events made me refill the scrip. For last two months felt spiral downward, experiencing the worst of panic and depression and couldn’t figure out why this was so different- even added CBD to take the edge off. Xmas holidays had to get back to therapy- learned my generic was switched to LUPIN — same as PP, sudden rush then end of day short tempered- also nauseous and anxious all the time. Switched back to PAR, within days back to normal. Seems many probs with Lupin - something is poisonous in their formula.

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Re: Michelle (# 23)

Yes, tell them to not give you the one manufactured by Lupin.

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Re: Avy (# 24)

Thought I was going crazy till I read all these review on the Lupin version of bupropion. Thanks!

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I was taking Global for four months and I was fine. Kroger switched to Lupin and I feel like dog poop. I went to the doc two days ago and he said EOD. The first day I did not take it I felt great. I took one this morning and I feel like I have been hit by a truck. I called and he said just stop. The FDA needs to look into this medication ASAP. Dizzy, nausea, disoriented, faint, terrible.

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Re: Peggy (# 21)

thank you for sharing. I'm glad I'm not the only one. It is really messing with me. Do I just ask the pharmacy?

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Re: Peggy (# 21)

Sorry to hear about your experience. Mine was much the same. The reason it feels good in the morning and not in the afternoon is because the XR (extended release) mechanisms are poorly made in Lupin pills.

Ask your pharmacy to switch back to the old generic because Lupin does not work for you. You could also discuss with your doctor switching to bupropion SR twice a day. Switching to SR helped me.

I've also had problems with Lupin quetiapine (Seroquel). I'm almost convinced Lupin is making completely counterfeit drugs. So many pharmacies are switching to Lupin because they're cheap. Placing complaints with the FDA gets absolutely nowhere, because the FDA is full of pharmaceutical executives who are there to purposefully block taking action against pharmaceutical companies.

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Re: Michelle (# 20)

Have them change the generic to the one made by Pharma. If they don't have it, check other pharmacies.

I've been on Wellbutrin many years. Recently the pharmacy changed to Lupin. All hell broke loose! For 2 months I didn't realize it was the pill. Basically I went cold turkey!

Spread the word!

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I just started my buporion 150 hcl xl (extended release) from lupin, and I am not happy. I have been feeling very irritable, and my sugar cravings have come back! I'm fine in the morning, but mid to late afternoon, I feel like I can snap at the littlest things. It doesn't feel like extended release to me at all. It's like I get a little "high" in the morning because it's too strong at first, and then in the afternoon I feel like I'm withdrawing or something.

I was taking buporion hcl xl 150 mg(extended release) from global/impax pharmaceuticals, and I felt it was truly extended release. It made me feel the best I've felt in a long time. I'm so disappointed, I'm going to talk to my dr.

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Re: BJR (# 17)

This thread is about Lupin bupropion, not Cipla or PAR. I'm glad you found a brand that works for you though. PAR seems to have the most positive reviews.

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Also, I wanted to add I found par at Walmart & when I told them about my reaction and why I was transferring the pharmacist put a note on my file right away to make sure I only got par in the future. So maybe try Walmart if you are looking.

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Re: mmmm123 (# 13)

At my pharmacy once you walk away no matter what side effects may come they do not return or exchange pills. It has been like this at every longs and cvs I've tried before at so I would say everyone check your prescriptions at the counter! I went through a horrible experience with cipla where I was extremely irritable. Almost psychotic & I just felt like I was losing it which was way worse than the loss of motivation I was taking it for!

Finally got par today and after a couple hours my anger subsided & I felt like a completely different person. So yea idk everyone is different and I'm usually a paradox. On cipla and bupropion in general in the beginning it would knock me out into deep sleep and make me calm and out of it. I feel wide Awake on the par pill. I think cipla is dumping the drug because I had a similar calming effect on addedal before.

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Re: Ellen (# 15)

Lupin has a published list of their ingredients. Nickel does not seem to be an ingredient.

Inactive ingredients: ammonium hydroxide, colloidal silicon dioxide, dibutyl sebacate, ethylcellulose, glyceryl behenate, hydrophobic colloidal silica, hydroxypropyl cellulose, iron oxide black, L-cysteine hydrochloride monohydrate, methacrylic acid copolymer dispersion, polyvinyl alcohol, povidone, propylene glycol, shellac and triethyl citrate. The tablets are printed with edible black ink

lupinpharmaceuticals.com/pdf/17/06/bupropion-XL-tabs-mg-10-2016.pdf

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I have been taking Buproprion XL 300 mg for many years for chronic depression. Things had been going fine until last summer when I started having stomach pain and in the evening my legs would develop hives. All would clear by morning and then it would start again. I had a GI workup, almost had my gallbladder out and then after about 3 months it stopped. I have been fine for the last 6 months and the same symptoms restarted. I just realized it was when my Buproprion manufacturer was changed to Lupin with my last refill. I have a severe nickel allergy and wonder if there might be nickel in this generic. Anyone else have these symptoms?

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Re: Verwon (# 1)

I just found out I was taking Lupin and it did not work. Not feeling well, super anxious and insomnia.

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