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72 Topics Found
Mepolizumab
Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis, and hypereosinophilic syndrome (HES).[3] It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system. The most common side effects include headache, injection site reactions, and back pain.[2] Contents 1 Medical uses 2 Side effects 3 Overdose 4 Interactions 5 Pharmacol...
Felodipine
Felodipine is a medication of the calcium channel blocker type which is used to treat high blood pressure. It was patented in 1978 and approved for medical use in 1988.[2] Contents 1 Medical uses 2 Adverse effects 3 Interactions 4 Mechanism of action 5 Chemistry 6 History 7 Society and culture 8 References Medical uses Felodipine is used to treat high blood pressure and stable angina.[1][3] It should not be used for people who are pregnan...
Alectinib
Alectinib (INN,[2] marketed as Alecensa) is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK)[3][4] and is used to treat non-small-cell lung cancer (NSCLC). It was developed by Chugai Pharmaceutical Co. Japan, which is part of the Hoffmann-La Roche group. Contents 1 History, clinical trials, Approvals and medical uses 2 Contraindications 3 Side effects 4 Interactions 5 Pharmacology 5.1 Mechanism of action 5.2 Pharmacok...
Drug Index
Pindolol, sold under the brand name Visken among others, is a nonselective beta blocker which is used in the treatment of hypertension.[1][2] It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A autoreceptors, and has been researched as an add-on therapy to selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression.[3][4][5] Contents 1 Medical u...
Astemizole
Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It was withdrawn from the market globally in 1999 because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade).[2][3] Contents 1 Pharmacology 2 Toxicity 3 References 4 Extern...
Drug Index
Guanadrel is an antihypertensive agent.[1] It is used in the form of its sulfate. Contents 1 Mechanism of action 2 Chemistry 3 References 4 External links Mechanism of action Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump; guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve...
Drug Index
Alectinib (INN,[2] marketed as Alecensa) is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK)[3][4] and is used to treat non-small-cell lung cancer (NSCLC). It was developed by Chugai Pharmaceutical Co. Japan, which is part of the Hoffmann-La Roche group. Contents 1 History, clinical trials, Approvals and medical uses 2 Contraindications 3 Side effects 4 Interactions 5 Pharmacology 5.1 Mechanism of action 5.2 Pharmacok...
Drug Index
Felodipine is a medication of the calcium channel blocker type which is used to treat high blood pressure. It was patented in 1978 and approved for medical use in 1988.[2] Contents 1 Medical uses 2 Adverse effects 3 Interactions 4 Mechanism of action 5 Chemistry 6 History 7 Society and culture 8 References Medical uses Felodipine is used to treat high blood pressure and stable angina.[1][3] It should not be used for people who are pregnan...
Drug Index
Eletriptan, sold under the brand name Relpax and used in the form of eletriptan hydrobromide, is a second generation triptan medication intended for treatment of migraine headaches.[3][4] It is used as an abortive medication, blocking a migraine attack which is already in progress. Eletriptan is marketed and manufactured by Pfizer Inc. Contents 1 Approval and availability 2 Mechanism of action 3 Side effects 4 Contraindications 5 Interactions 6 Additional che...
Drug Index
Mexiletine (INN) (sold under the brand names Mexitil and NaMuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and nausea. It works as a non-selective voltage-gated sodium channel blocker and belongs to the Class IB group of anti-arrhythmic medications.[1] Contents 1 Medical uses 2 Adverse effects 3 Pharmacology 4 Synthesis 5 Socie...
Phenoxybenzamine
Phenoxybenzamine (marketed under the trade name Dibenzyline) is a non-selective, irreversible alpha blocker. Contents 1 Uses 1.1 Investigational 2 Pharmacology 3 Stereoisomerism 4 See also 5 References 6 External links Uses It is used in the treatment of hypertension, and specifically that caused by pheochromocytoma. It has a slower onset and a longer-lasting effect compared with other alpha blockers. It was also the first alpha blocker to be used for treatment of benign prostatic h...
Drug Index
Levobunolol (trade names AKBeta, Betagan, Vistagan, among others) is a non-selective beta blocker. It is used topically in the form of eye drops to manage ocular hypertension (high pressure in the eye) and open-angle glaucoma.[2] Contents 1 Contraindications 2 Side effects 3 Interactions 4 Pharmacology 4.1 Mechanism of action 4.2 Pharmacokinetics 5 Chemistry 6 References Contraindications Like other beta blockers, levobunolol is contraindicated in patients with airwa...
Drug Index
Nisoldipine is a pharmaceutical drug used for the treatment of chronic angina pectoris and hypertension. It is a calcium channel blocker of the dihydropyridine class. It is sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels.[1] It was patented in 1975 and approved for medical use in 1990.[2] Contents 1 Contraindications 2 Adverse effects 3 Interactions 4 Pharmacology 4.1 Mechanism of action 5 Refer...
Drug Index
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA.[1] Several ASOs have been approved in the United States, the European Union, and elsewhere. Contents 1 Nomenclature 2 Pharmacokineti...
Drug Index
Phentolamine, sold under the brand name Regitine among others, is a reversible[1] nonselective α-adrenergic antagonist.[2] Contents 1 Mechanism 2 Uses 3 Chemistry 4 Adverse effects 5 References 6 External links Mechanism Its primary action is vasodilation due to α1 blockade.[3] Non-selective α-blockers can cause a much more pronounced reflex tachycardia than the selective α1 blockers. Like the selective α1 blocker...
Drug Index
Isoprenaline, or isoproterenol (Brand name: Isoprenaline Macure), is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. It is a non-selective β adrenoceptor agonist that is the isopropylamine analog of epinephrine (adrenaline).[2] Contents 1 Medical uses 2 Contraindications 3 Adverse effects 4 Pharmacology 4.1 Pharmacodynamics 4.2 Pharmacokinetics 5 Chemistry 6 History 7 Society and culture 7.1 Brands 8 Refer...
Drug Index
Chloroprocaine (trade name Nesacaine, Nesacaine-MPF) (often in the hydrochloride salt form as the aforementioned trade names) is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine vasodilates; this is in contrast to cocaine which vasoconstricts. Chloroprocaine is an ester anesthetic.[1] Contents 1 Uses 2 Subarachnoid block 3 Obstetrics 4 Synthesis 5 See also 6 References Uses Chloroprocaine is used for regional anaest...
Drug Index
Clevidipine (INN,[2] trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Clevidipine is used IV only and practitioners titrate this drug to lower blood pressure. It has a half-life of approximately one minute. It is rapidly inactivated by esterases. It was approved by the United States Food and Drug Administration on August 1, 2008. Contents 1 Basic chemical and ...
Nisoldipine
Nisoldipine is a pharmaceutical drug used for the treatment of chronic angina pectoris and hypertension. It is a calcium channel blocker of the dihydropyridine class. It is sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels.[1] It was patented in 1975 and approved for medical use in 1990.[2] Contents 1 Contraindications 2 Adverse effects 3 Interactions 4 Pharmacology 4.1 Mechanism of action 5 Refer...
Drug Index
Phentolamine, sold under the brand name Regitine among others, is a reversible[1] nonselective α-adrenergic antagonist.[2] Contents 1 Mechanism 2 Uses 3 Chemistry 4 Adverse effects 5 References 6 External links Mechanism Its primary action is vasodilation due to α1 blockade.[3] Non-selective α-blockers can cause a much more pronounced reflex tachycardia than the selective α1 blockers. Like the selective α1 blocker...