Plecanatide

Plecanatide (brand name Trulance), is a drug approved by the FDA for the treatment of chronic idiopathic constipation (CIC)[1] and irritable bowel syndrome with constipation.[2] Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP.[3][4] Contents 1 Medical uses 2 Contraindications 3 Pharmacology 3.1 Structure and function 3.2 Mechanism of action 3.3 Phar... [wikipedia]