Zyrtec And Benadryl

took 1 10 mg zyrtec at 3 pm, now 5 hours later still no relief. Would it be ok to take 1 25 mg benadryl before I go to bed?

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Hi Karin,

I wouldn't recommend taking either of these drugs together in or around the same time frame, as my findings state that there are potentially unsafe interactions between Zyrtec and Benadryl. Quoted below are the precautions you should be aware of:

"Using Zyrtec (cetirizine) together with Benadryl (diphenhydramine) may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor."

If you're taking each medication at completely different times of the day (i.e. morning and bedtime), then I wouldn't sweat the interaction, but it's always good to play it safe.

I hope this info helps!

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