Lisinopril Tablets (Page 3) (Top voted first)

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I have been taking Lisinopril 20 mg from manufacturer Lupin for years. My most recent renewal was the same color and Lupin on one side and 20 on other but the pill is half the size of the one I have been getting. Still says Lupin but I am concerned. Anyone notice the difference?

127 Replies (7 Pages)

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47

Maybe you agent J should open your eyes and listen to people who have been affected by this drug. There are none so blind as those who won't see Maybe you work for the manufacturer and are trying to cover their ass

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48

then why are on here, 'Agent J'? To insult people and basically call them names?

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49

look Barry, you are contributing to group think and it is not based in science. Just admit it.

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51

Well, I take that same 20Mg pill, and I have zero change in any sense of feel or effect, I would guess that my "empirical" experience would mirror 95% of the users.
You all act like they changed the formula and added some mystery ingredients that have caused a absolute change in symptoms or relief. That is so incredibly unlikely it fall under the confirmation bias category. If that smaller pill was delivered inside a ball of bread and never seen to be smaller, I seriously doubt this thread would exist.

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56

Lori. Doctors at Johns Hopkins are world famous but they really have no knowledge of the manufacture process by Lupin in making Lisinopril. We the end users know our Meds and know of a change in how our bodies tolerate these Meds

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58

Hi Barry - I didn't post the Johns Hopkins comment. And I completely agree with you!

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59

I am having stomach distriss with smaller size 19 mg lisiniprol. Manufacturers say everything the same. Anyone else having stomach problems. Gut fills full and bloated.

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67

Hello Kacey. It is definitely the new smaller pill that is causing adverse events with all of us. Lupin is the manufacturer and they have screwed up a medication all for the almighty dollar

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70

It's not that they changed ingredients but that they removed inactive ingredients that could possibly be buffers to the medication being tolerated.

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82

They are made with some of the inactive ingredients missing now and for those people with digestive problems those inactive ingredients could have been buffers for the gut and helped them tolerant the active ingredients that are still there

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83

Agent J. They changed the pill to smaller version in 2017 so your statistics don't hold water. You are the only one out there denying the problems. Are you a pawn for Lupin Pharm?

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84

The active ingredients supposedly the same but by taking out three of the inactive ingredients changes the molecular compound and what the inactive ingredients may have done helped people tolerate the active ingredients for digestion.

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101

Re: Barry (# 3) Expand Referenced Message

Just started taking then smaller 20 mg lisinopril, blood pressure was spiked around 168/90 and took 1+ 1/2 last night about 2 am, so blood pressure still up around 150 in the afternoon, took my ohther meds which help lower Blood pressure but also took another 1/2 lisinopril. It is 10:30 pm now and BP is 166/87. Something about the smaller pill is not cutting it.

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8

It is possible that one of Lupin's manufacturing facilities may have started using different inactive ingredients/fillers, which could conceivably alter the size. They do note that the inactive ingredients may vary. The standard size is one thing and is usually what everyone expects, but they are free to change it, at any time.

Have you double checked the imprints and with your pharmacy?

The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, headache, increased urination, and hypotension.

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25

Glad I found this thread. I knew I wasn't crazy when I saw the smaller pills, but the pharmacist dismissed my suspicions. I haven't felt different yet--but it's only been a day. I'll monitor how I feel in the next few.

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31

Yes, I have also noticed that the pills were smaller.

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32

Having taken lisinopril 20mg twice daily for many years, supplied by Wal-mart Home Delivery, I was dismayed to find that the pill size in my recent order has decreased by half, although the strength is purportedly the same. The new pill is barely distinguishable from the hydrochlorothiazide pill I take at the same time every morning and the two are easily confused. Although the two pills are a slightly different color, both are pale --one pink and the other peach, it requires an eagle's eyes to differentiate between the two -- which I, at 81, do not have.

In calling the Wal-mart pharmacy to ask if it would be possible to get the original size pill in future orders I was told that the manufacturer, Lupin, has discontinued it and because they have a long-term contract with Lupin, there is nothing they can do. They did give me Lupin's phone number however, and I phoned their customer service today to report my dissatisfaction with the new pill size. I was transferred to their medical division and the individual I spoke to there was extremely thorough in documenting my complaint, asking a host of questions about the specific pill's color, shape, lot no., expiration date, NDC no., dispensing pharmacy phone and address, etc., etc., with particular attention to any adverse effects I might have experienced on the smaller pill (none so far, although I've only taken them for three days). The Lupin rep said all the info would be passed on to upper management.

I was very impressed with the interest shown in my complaint by Lupin and would strongly urge other lisinopril users -- especially those who ARE experiencing adverse effects on the smaller pill --to phone the company; the number is 1-800-466-1450.

The Lupin rep explained that the active ingredient remains the same while the fillers have been greatly reduced, resulting in a substantial savings for the company not only in reduced materials required but also in its ability to produce a greater quantity of smaller pills with no increase in labor costs for manufacturing, packaging and shipping. This of course makes rational economic sense for the company, but without customer feedback how are they to know the far-reaching effect of their product-revision decisions that may seem inconsequential to them but may have major consequences for the ultimate consumers of the product? Consumers need to call!

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33

I have been forced to change to Losartan 50 mg twice a day. Lupin is covering their back but all the feedback I am receiving tells me they screwed with the formula. People are having adverse reactions left and right

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34

I also received the new smaller pill. I called the manufacturer and they told me they decreased the size of the pill by taking the "filler" out of the pill, and said it was still the same dosage. My blood pressure was perfect for years, until they changed the size of the pill. My ankles are so swollen, and my cardiologist took my pressure today, and it was extremely high. She's very concerned. It takes many years to find a few medications that keep your blood pressure under control, and now the manufacturer is playing with our lives.

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35

exactly same happened to me For years took lisinopril 20 mg and BP was perfectly regulated Then Lupin messed with the pill making it smaller and they claim exactly the same But that is a lie Too many people are having adverse reactions I was forced to change to losartan but not getting job done It may take a long time until i am regulated again

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